Hypothalamic Actions of Apelin on Energy Metabolism: New Insight on Glucose Homeostasis and Metabolic Disorders
Abstract
Hypothalamus is key area implicated in control of glucose homeostasis. This structure integrates nervous and peripheral informations to adapt a response modifying peripheral glucose utilization and maintaining energetic balance. Among peripheral signals, adipokines such as adiponectin and leptin are of special importance since deregulations of their actions are closely associated to metabolic disorders such as obesity and type 2 diabetes. During the past ten years, we have identified a new adipokine named apelin which has emerging role in the control of metabolism. The originality of the apelinergic system is to be largely represented in peripheral tissues (adipose tissue, intestine, etc.) and in the brain. Then, apelin is released by adipose tissue as all adipokines, but also present another crucial role as neurotransmitter in hypothalamic neurons. By acting in the whole body, apelin exerts pleiotropic actions and is now considered as a major determinant of physiological functions. Besides its general beneficial effects on peripheral targets, central action of apelin remains still a matter of debate. In this review, we have made a parallel between peripheral vs. central actions of apelin in term of signalization and effects. Then, we have focused our attention on hypothalamic apelin and its potential role in glucose metabolism and associated pathologies.
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Apelin has been implicated in disorders of glucose metabolism and in liver fibrosis.
“Apelin has been shown to be involved in glucose metabolism disorders and in hepatic fibrosis [52,53].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [52]
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- Authors
- Knauf, C., Drougard, A., Fournel, A., Duparc, T., & Valet, P.
- Affiliations
- Inserm (FR)
- UCLouvain (BE)
- Corresponding author
- Knauf, C.
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2013-08-15
- Volume
- 45
- Issue
- 13
- Pages
- 928-934
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2016144268
- Cited by
- 38
- References
- 70
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 8 · 2014: 4
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- apelin, hypothalamus, glucose homeostasis, energy metabolism, adipokines, central nervous system, neurotransmitters, obesity, type 2 diabetes, metabolic disorders, leptin, adiponectin
- MeSH terms
- Apelin, Animals, Diabetes Mellitus, Type 2, Energy Metabolism, Glucose, Homeostasis, Humans, Hypothalamus, Obesity, Intercellular Signaling Peptides and Proteins
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