Genistein Prevents Cadmium-Induced Neurotoxic Effects through its Antioxidant Mechanisms
Abstract
INTRODUCTION: Cadmium-induced neurotoxic effects are mediated through adverse oxidative stress and calcium signaling. Genistein, a phytoestrogen is a potent antioxidant and exhibits property to cross blood-brain barrier. METHODS: Experimental model of cadmium-induced neurotoxic effects were induced by treatment with cadmium (5 mg/kg) for 28 days in wistar rats. For determining the protective effect, genistein was administered at a dose of (10 mg/kg) for 7 days followed by cadmium treatment for 28 days. Serum and tissues were analyzed for various oxidative stress markers such as total antioxidant capacity, total oxidant levels, non-enzymic antioxidants, enzymic antioxidants, lipid peroxide levels and protein carbonyl content. RESULTS: The results showed significant increase in the oxidative stress markers during cadmium treatment was attenuated in rats treated with genistein followed by cadmium treatment. In addition, cadmium induced alterations and activities of ATPase were significantly restored by genistein treatment. CONCLUSION: The present study observations show promising results of genistein against cadmium-induced neurotoxic effects in wistar rats. Thus its potent antioxidant and cytoprotective effects could act as potent therapeutic agent against various neuro-degenerative diseases involving oxidative stress as primary mechanism.
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Genistein exerts potent antioxidant effects due to numerous phenolic moieties.
“owing to the presence of numerous phenolic moieties in its structure, genistein exerts potent anti-oxidant effects (Gong et al., 2015)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Gong et al., 2015
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“Owing to the presence of numerous phenolic moiety in its structure, genistein exhibits potent anti-oxidant property [151-153].”
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Zhang, L., Li, H., Chong, T., et al. (2014) · BioMed Research International · doi:10.1155/2014/598630 · Cited by 33 · see citing works
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“2000), as well as the neurotoxicity (Dong 2015; Gong et al. 2015).”
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Backgroundde Jesus, L. C. L., Soares, R.-E. P., Moreira, V. R., Pontes, R. L., Castelo-Branco, P. V., & Pereira, S. R. F. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00456-18 · Cited by 20 · see citing works
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BackgroundZhang, Y., Yin, L., Dong, J., et al. (2022) · Antioxidants · doi:10.3390/antiox11102037 · Cited by 10 · see citing works
“The reported evidence indicates that phenolic compounds, especially isoflavones, can protect nerve cells by activating the intracellular antioxidant system to scavenge ROS [16,27].”
BackgroundCobb‐Abdullah, A., Lyles, L. R., Odewumi, C. O., Latinwo, L. M., Badisa, V. L. D., & Abazinge, M. D. (2019) · Environmental Toxicology · doi:10.1002/tox.22766 · Cited by 7 · see citing works
Zhou, X., Shi, Z.-Y., Chen, H., et al. (2024) · Aquaculture Nutrition · doi:10.1155/anu/2897742 · Cited by 3 · see citing works
García‐Rodríguez, M. D. C., Valle-Castillo, G. A., & Hernández‐Cortés, L. M. (2022) · Nutrición Hospitalaria · doi:10.20960/nh.04163
- Authors
- Gong, D.-K., Liu, B.-H., & Tan, X.-H.
- Affiliations
- Jingzhou Central Hospital (CN)
- Venue
- Drug Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2014-06-11
- Volume
- 65
- Issue
- 02
- Pages
- 65-69
- ISSN
- 2194-9379 (ISSN-L)
- 2194-9387
- OpenAlex
- W2319776123
- Cited by
- 21
- References
- 0
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 2
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- genistein, cadmium neurotoxicity, oxidative stress, antioxidant activity, phytoestrogens, lipid peroxidation, protein carbonylation, ATPase activity, neuroprotection, neurodegenerative diseases, blood-brain barrier
- MeSH terms
- Acetylcholinesterase, Adenosine Triphosphatases, Animals, Antioxidants, Brain, Male, Oxidative Stress, Cadmium Chloride, Genistein, Rats
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