Combined preclinical magnetic particle imaging and magnetic resonance imaging: initial results in Mice
Open accessAbstract
Purpose: Magnetic particle imaging (MPI) is a new radiologic imaging modality. For the first time, a commercial preclinical scanner is installed. The goal of this study was to establish a workflow between MPI and magnetic resonance imaging (MRI) scanners for a complete in vivo examination of a mouse and to generate the first co-registered in vivo MR-MP images. Materials and Methods: The in vivo examination of five mice were performed on a preclinical MPI scanner and a 7 Tesla preclinical MRI system. MRI measurements were used for anatomical referencing and validation of the injection of superparamagnetic iron oxide (SPIO) particles during a dynamic MPI scan. We extracted MPI data of the injection phase and co-registered it with MRI data. Results: A workflow process for a combined in vivo MRI and MPI examination was established. A successful injection of ferucarbotran was proven in MPI and MRI. MR-MPI co-registration allocated the SPIOs in the inferior vena cava and the heart during and shortly after the injection. Conclusion: The acquisition of preclinical MPI and MRI data is feasible and allows the combined analysis of MR-MPI information. Key Points: • The first commercial preclinical MPI system was installed and has been tested successfully in an in vivo experiment. • This MPI system can detect SPIO in vivo in a mouse model. • First time performance of a combined in vivo MPI-MRI examination. • Co-registered MR-MPI allows high temporal resolution imaging of the vascular SPIO distribution. Citation Format: • Kaul MG., Weber O, Heinen U et al. Combined Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging: Initial Results in a Mouse. Fortschr Röntgenstr 2015; 187: 347 – 352
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Iron oxide nanoparticle-enhanced MRI-MPI is suitable for vascular imaging, as shown by first proof-of-principle experiments in animal models.
“These first proof-of-principle experiments in animal models exemplify the suitability of iron oxide nanoparticle-enhanced MRI-MPI for vascular imaging [194].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [194]
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- Authors
- Kaul, M., Weber, O., Heinen, U., Reitmeier, A., Mummert, T., Jung, C., Raabe, N., Knopp, T., Ittrich, H., & Adam, G.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Philips (Germany) (DE)
- Bruker (Germany) (DE)
- Corresponding author
- Kaul, M.
- Venue
- RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
- Publisher
- Georg Thieme Verlag KG
- Published
- 2015-04-21
- Volume
- 187
- Issue
- 05
- Pages
- 347-352
- ISSN
- 1438-9010 (ISSN-L)
- 1438-9029
- OpenAlex
- W1960198142
- Cited by
- 42
- References
- 15
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 2
- FWCI
- 3.81
- Type
- journal article
- Language
- de
- Open access
- bronze
- doi.org
- Locations
- RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (publishedVersion)
- PubMed (publishedVersion)
- tub.dok (Hamburg University of Technology) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Geomagnetism and Paleomagnetism Studies
- Keywords
- magnetic particle imaging, superparamagnetic iron oxide nanoparticles, ferucarbotran, small animal imaging, mouse model, in vivo imaging, inferior vena cava, heart, temporal resolution
- MeSH terms
- Animals, Blood Flow Velocity, Dextrans, Image Enhancement, Image Interpretation, Computer-Assisted, Pilot Projects, Sensitivity and Specificity, Subtraction Technique, Vena Cava, Inferior, Reproducibility of Results, Magnetic Resonance Angiography, Mice, Workflow, Magnetite Nanoparticles, Multimodal Imaging
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