Fertility treatments in women who become pregnant and carried to viability, and the risk for long-term maternal cardiovascular morbidity
Abstract
Objective The objective of this study was to investigate whether patients who undergo fertility treatments (ovulation induction or in vitro fertilization) have an increased risk for future maternal cardiovascular morbidity. Design A population-based study compared the incidence of long-term cardiovascular morbidity in a cohort of women with and without a previous exposure to fertility treatments. Deliveries occurred during a 25-year period, with a mean follow-up of 11.7 years. Women with known cardiovascular disease and congenital cardiovascular malformations diagnosed before the index pregnancy and multiple pregnancies were excluded. Results During the study period, 99,291 patients met the inclusion criteria; 4.1% ( n = 4,153) occurred in patients with exposure to fertility treatments. Patients with exposure to fertility treatments did not have higher rates of cardiovascular morbidity. Using a Kaplan–Meier survival curve, patients with an exposure to fertility treatments had no higher cumulative incidence of cardiovascular hospitalizations. Using a Cox proportional hazards model, adjusted for confounders such as preeclampsia, diabetes mellitus, and obesity, exposure to fertility treatments remained unassociated with cardiovascular hospitalizations (adjusted hazard ratio = 1.1; 95% confidence interval, 0.9–1.3; p = 0.441). Conclusion In our population, during a mean follow-up period of 11.7, results showed no increased risk for cardiovascular morbidity in women undergoing fertility treatments.
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Risk of bias was assessed using ACROBAT-NRSI, which assesses potential risk of bias in observational studies in 7 domains.
“Risk of bias was assessed using ACROBAT-NRSI (A Cochrane Risk of Bias Tool: for Non-Randomized Studies of Interventions)”
From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [31]
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- Authors
- Ben-Yaakov, R., Kessous, R., Shoham-Vardi, I., Sergienko, R., Pariente, G., & Sheiner, E.
- Affiliations
- Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel
- Ben-Gurion University of the Negev (IL)
- Department of Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, Beer-Sheva, Israel
- Venue
- American Journal of Perinatology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-05-09
- Volume
- 33
- Issue
- 14
- Pages
- 1388-1393
- ISSN
- 0735-1631 (ISSN-L)
- 1098-8785
- OpenAlex
- W2346160276
- Cited by
- 18
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
- Keywords
- infertility treatment, ovulation induction, in vitro fertilization, cardiovascular hospitalization, long-term maternal outcomes, pregnancy outcomes, cardiovascular risk
- MeSH terms
- Adult, Cardiovascular Diseases, Female, Fertilization in Vitro, Follow-Up Studies, Humans, Israel, Obesity, Ovulation Induction, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Retrospective Studies, Risk Factors, Time Factors, Incidence, Proportional Hazards Models, Databases, Factual, Kaplan-Meier Estimate, Young Adult
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