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Disseminated Intravascular Coagulation: Objective Clinical and Laboratory Diagnosis, Treatment, and Assessment of Therapeutic Response

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Studies on the inflammatory-coagulant axis in the baboon response to E. coli: regulatory roles of proteins C, S, C4bBP and of inhibitors of tissue factor.

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Comparison of Immunological and Functional Assays for Measurement of Soluble Fibrin

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Shock-Associated Systemic Inflammation in Amniotic Fluid Embolism, Complicated by Clinical Death

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Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies

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Validation of ICD-10 Codes for Severe Maternal Morbidity at Delivery in a Public Hospital

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Effectiveness, reliability, and validity of new Japanese diagnostic criteria for obstetrical disseminated intravascular coagulation

Morikawa, M., Takeda, Y., Matsunaga, S., Makino, S., Eto, E., Serizawa, M., Nii, M., Takeda, J., Masuyama, H., & Itakura, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-68298-7 · Cited by 16

A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation

Trzeciak, S. W., Jones, A. E., Shapiro, N. I., Pusateri, A. E., Arnold, R. C., Rizzuto, M. A., Arora, T., Parrillo, J. E., & Dellinger, R. P. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181cf6fbc · Cited by 16

SIL-TAL1 Rearrangement is Related with Poor Outcome: A Study from a Chinese Institution

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Thrombopénie et grossesse : du diagnostic étiologique à la prise en charge thérapeutique

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Prolonged effect of GlycoPEGylated rFVIIa (40k-PEG-rFVIIa) in rabbits correlates to activity in plasma

Bjørn, S. E., Agersø, H., Thorup, I., Hermit, M. B., Sørensen, B. B., Stennicke, H. R., Ezban, M., Tranholm, M., & Johansen, P. B. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-11-0797 · Cited by 16

The efficacy of the administration of recombinant human soluble thrombomodulin in patients with DIC

Aota, T., Wada, H., Yamashita, Y., Matsumoto, T., Ohishi, K., Suzuki, K., Imai, H., Usui, M., Isaji, S., & Katayama, N. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1899-5 · Cited by 16

Efficacy evaluation of D‐dimer and modified criteria in overt and nonovert disseminated intravascular coagulation diagnosis

Li, W., Sha, M., Ma, W., Zhang, Z. P., Wu, Y., & Shi, D. M. (2016) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12467 · Cited by 16

The ISTH DIC score predicts outcome in non-septic patients admitted to a cardiovascular intensive care unit

Grafeneder, J., Krychtiuk, K. A., Buchtele, N., Schoergenhofer, C., Gelbenegger, G., Lenz, M. W., Wojta, J., Heinz, G., Huber, K., Hengstenberg, C., et al. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.06.017 · Cited by 16

Comparative Analysis of Three Machine-Learning Techniques and Conventional Techniques for Predicting Sepsis-Induced Coagulopathy Progression

Hasegawa, D., Yamakawa, K., Nishida, K., Okada, N., Murao, S., & Nishida, O. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072113 · Cited by 17

Antiviral anticoagulation

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Complex and prolonged hypercoagulability in coronavirus disease 2019 intensive care unit patients: A thromboelastographic study

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Effect of hypofibrinogenemia on obstetrical disseminated intravascular coagulation in Japan in 2018: a multicenter retrospective cohort study

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Heparinresistenz und Antithrombinmangel*

Maurin, N. (2009) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-009-1093-8 · Cited by 16

Disseminated intravascular coagulation in non-Hodgkin lymphoma

Chi, S., & Ikezoe, T. (2015) · International Journal of Hematology · doi:10.1007/s12185-015-1854-5 · Cited by 16

Disseminated Intravascular Coagulation (DIC) in a Kidney Donor Associated with Transient Recipient DIC

Bennett, W. M., Hansen, K. S., Houghton, D. C., & McEvoy, K. M. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00679.x · Cited by 16

Transfusion Medicine and the Pregnant Patient

Lee, A. I., & Kaufman, R. M. (2011) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2011.02.002 · Cited by 16

Disseminated Intravascular Coagulation (DIC) in Cancer

Saba, H. I., Morelli, G. A., & Saba, R. I. (2009) · Cancer treatment and research · doi:10.1007/978-0-387-79962-9_9 · Cited by 16

Transcatheter Arterial Embolization for Primary Postpartum Hemorrhage: Predictive Factors of Need for Embolic Material Conversion of Gelatin Sponge Particles to N-Butyl Cyanoacrylate

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The evolution of activated protein C plasma levels in septic shock and its association with mortality: A prospective observational study

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Endotoxinemia-induced changes in coagulation as measured by rotation thrombelastometry technique and conventional laboratory tests: results of a pilot study on pigs

Velik‐Salchner, C., Streif, W., Innerhofer, P., Maier, S., Knotzer, H., Pajk, W., Klingler, A., Mittermayr, M., & Haas, T. (2008) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e32831be9ad · Cited by 16

Foxtail-associated endocarditis in a cat

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D-dimer assays: The current status and new assay technologies

Dempfle, C.-E. H. (2005) · Thrombosis Research · doi:10.1016/j.thromres.2005.08.006 · Cited by 16

Disseminated Intravascular Coagulation

Stokol, T. (2022) · Schalm's Veterinary Hematology · doi:10.1002/9781119500537.ch92 · Cited by 16

Mortality, diagnosis, and etiology of disseminated intravascular coagulation—a systematic review and meta-analysis: communication from the ISTH SSC subcommittee on disseminated intravascular coagulation

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Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

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Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation

Ling, L., Huang, X., Liu, C., Liao, J., & Zhou, J. (2021) · Thrombosis Journal · doi:10.1186/s12959-021-00338-y · Cited by 15

Inflammation and Coagulation

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Role of biological markers and CT severity score in predicting mortality in patients with COVID‑19: An observational retrospective study

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Plasma Soluble Fibrin Is Useful for the Diagnosis of Thrombotic Diseases

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Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19

de Sá, K. S. G., Amaral, L. A., Rodrigues, T. S., Caetano, C. C. D. S., Becerra, A., Batah, S. S., Lopes, F. T., de Oliveira, I. M., Lopes, L. D. S., de Almeida, L., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012222 · Cited by 16

Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024: part 4—trauma, burn, obstetrics, acute pancreatitis/liver failure, and others

Hayakawa, M., Seki, Y., Ikezoe, T., Yamakawa, K., Okamoto, K., Kushimoto, S., Sakamoto, Y., Itagaki, Y., Takahashi, Y., Ishikura, H., et al. (2025) · International Journal of Hematology · doi:10.1007/s12185-025-03918-0 · Cited by 15

Recombinant factor VIIa and other pro-haemostatic therapies in primary postpartum haemorrhage

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Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange

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Antithrombin effect on coagulation and fibrinolytic profiles after living donor liver transplantation: a pilot study

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Clinical features of patients with lung cancer accompanied by thromboembolism or disseminated intravascular coagulation

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D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?

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Dı́az, E., Menéndez, R. A., Cortés, P. V., Escapa, M. G., Suberviola, B., Lázaro, A. S., Marcos-Neira, P., Quintana‐Díaz, M., & González, M. C. (2021) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2020.06.007 · Cited by 15

Sonoclot Signature Analysis: A New Point-of-Care Testing Method for Defining Heat Stroke-Induced Coagulopathy

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Tissue-Type Plasminogen Activator-Inhibitor Complex as an Early Predictor of Septic Shock: A Retrospective, Single-Center Study

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Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis

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The relationship between antithrombin administration and inflammation during veno-venous ECMO

Panigada, M., Spinelli, E., Falco, S. D., Consonni, D., Novembrino, C., Anzoletti, M. B., Panarello, G., Occhipinti, G., dos Santos, C. C., Pesenti, A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17227-7 · Cited by 15

From appearance to essence: 10 years review of atypical amniotic fluid embolism

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Transfusion requirements and clinical outcome in intensive care patients receiving continuous renal replacement therapy: comparison of prostacyclin vs. heparin prefilter administration

Windeløv, N. A., Ostrowski, S. R., Perner, A., & Johansson, P. I. (2010) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e328338dc99 · Cited by 15

Épidémiologie des états septiques graves

Brun‐Buisson, C. (2006) · La Presse Médicale · doi:10.1016/s0755-4982(06)74627-9 · Cited by 15

Analysis of the Cutoff Values in Fibrin-Related Markers for the Diagnosis of Overt DIC

Hatada, T., Wada, H., Kawasugi, K., Okamoto, K., Uchiyama, T., Kushimoto, S., Seki, Y., Okamura, T., Imai, H., Kaneko, T., et al. (2011) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029611429786 · Cited by 15

Disseminated Intravascular Coagulation (DIC) at an Early Phase of Trauma Continuously Proceeds to DIC at a Late Phase of Trauma

Murakami, H., Gando, S., Hayakawa, M., Sawamura, A., Sugano, M., Kubota, N., Uegaki, S., & Jesmin, S. (2012) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029611426138 · Cited by 15

Disseminated Intravascular Coagulation During Resection of a Meningioma: Case Report

Velez, A., & Friedman, W. A. (2011) · Neurosurgery · doi:10.1227/neu.0b013e31820a181a · Cited by 15

Are there any additional mechanisms for haemolysis in HELLP syndrome?

Sabau, L., Terriou, L., Provôt, F., Fourrier, F., Roumier, C., Caron, C., Susen, S., & Ducloy‐Bouthors, A. ‐. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.03.014 · Cited by 15

High-mobility group box 1 is associated with neurological outcome in patients with post-cardiac arrest syndrome after out-of-hospital cardiac arrest

Omura, T., Kushimoto, S., Yamanouchi, S., Kudo, D., & Miyagawa, N. (2016) · Journal of Intensive Care · doi:10.1186/s40560-016-0161-4 · Cited by 16

Transfusion of Blood and Blood Products

Marik, P. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-11020-2_38 · Cited by 16

Examination of biomarker expressions in sepsis-related DIC patients

Shimizu, M., Konishi, A., & Nomura, S. (2018) · International Journal of General Medicine · doi:10.2147/ijgm.s173684 · Cited by 15

Apixaban for the Treatment of Chronic Disseminated Intravascular Coagulation: A Report of Two Cases

Janjetovic, S., Holstein, K., Dicke, C., Bokemeyer, C., & Länger, F. P. (2018) · Hämostaseologie · doi:10.1055/s-0038-1675386 · Cited by 15

Underlying Disorders, Clinical Phenotypes, and Treatment Diversity among Patients with Disseminated Intravascular Coagulation

Ohbe, H., Yamakawa, K., Taniguchi, K., Morita, K., Matsui, H., Fushimi, K., & Yasunaga, H. (2020) · JMA Journal · doi:10.31662/jmaj.2020-0023 · Cited by 15

Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa

Kawasugi, K., Wada, H., Honda, G., Kawano, N., Uchiyama, T., Madoiwa, S., Takezako, N., Suzuki, K., Seki, Y., Ikezoe, T., et al. (2021) · Thrombosis Journal · doi:10.1186/s12959-021-00264-z · Cited by 15

Coagulopathy monitoring and anticoagulation management in COVID-19 patients on ECMO: Advantages of a heparin anti-Xa-based titration strategy

Rhoades, R., Leong, R. L., Kopenitz, J., Thoma, B. N., McDermott, L., Dovidio, J., Barletti, S., Gong, J. Z., Massey, H. T., McKenzie, S. E., et al. (2021) · Thrombosis Research · doi:10.1016/j.thromres.2021.04.008 · Cited by 15

Effect of Posttraumatic Donor’s Disseminated Intravascular Coagulation in Intrathoracic Organ Donation and Transplantation

Valdivia, M., Chamorro-Jambrina, C., Romera, M. A., Balandín, B., & Redondo, M. P. (2007) · Transplantation Proceedings · doi:10.1016/j.transproceed.2007.07.052 · Cited by 15

A comparison of disseminated intravascular coagulation scoring systems and their performance to predict mortality in sepsis patients: A systematic review and meta-analysis

Kiya, G. T., Abebe, G., Mekonnen, Z., Tadasa, E., Milkias, G., & Asefa, E. T. (2025) · PLoS ONE · doi:10.1371/journal.pone.0315797 · Cited by 16

Plasma H3.1 nucleosomes as biomarkers of infection, inflammation and organ failure

Filippini, D. F. L., Jiang, M. Q., Kramer, L., van der Poll, T., Cremer, O. L., Hla, T. T. W., Retter, A., & Bos, L. D. J. (2025) · Critical Care · doi:10.1186/s13054-025-05415-6 · Cited by 14

Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated Coagulopathy

Wiedermann, C. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012474 · Cited by 14

Fibrinogen Is Associated with Prognosis of Critically Ill Patients with Sepsis: A Study Based on Cox Regression and Propensity Score Matching

Yao, C., Zhang, G., Zhang, N., Li, R., Sun, S., Zhang, L., Xia, Y. X., Chen, S., Sun, J., & Chen, M. (2023) · Mediators of Inflammation · doi:10.1155/2023/7312822 · Cited by 14

Diagnosis of overt disseminated intravascular coagulation in critically Ill adults by Sonoclot coagulation analysis

Wan, P., Tong, H., Zhang, X.-Q., Duan, P.-K., Tang, Y., & Su, L. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1601-3 · Cited by 14

D-Dimer Testing in Laboratory Practice*

Tripodi, A. (2012) · Laboratory Medicine Online · doi:10.3343/lmo.2012.2.3.119 · Cited by 14

An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis

Aota, T., Wada, H., Yamashita, Y., Matsumoto, T., Ohishi, K., Suzuki, K., Imai, H., Usui, M., Isaji, S., Asakura, H., et al. (2016) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029616654263 · Cited by 14

The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine

Koami, H., Sakamoto, Y., Sakurai, R., Ohta, M., Imahase, H., Yahata, M., Umeka, M., Miike, T., Nagashima, F., Iwamura, T., et al. (2016) · Medicine · doi:10.1097/md.0000000000004514 · Cited by 14

Platelets and infections in the resource‐limited countries with a focus on malaria and viral haemorrhagic fevers

Thachil, J. V. (2017) · British Journal of Haematology · doi:10.1111/bjh.14582 · Cited by 14

Thrombotic Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia, and Disseminated Intravascular Coagulation

Kalpatthi, R. V., & Kiss, J. E. (2020) · Critical Care Clinics · doi:10.1016/j.ccc.2019.12.006 · Cited by 14

Risk assessment of venous thromboembolism in hematological cancer patients: a review

Chan, T. S. Y., Hwang, Y., & Tse, E. (2020) · Expert Review of Hematology · doi:10.1080/17474086.2020.1751608 · Cited by 14

Extrapulmonary manifestations of severe acute respiratory syndrome coronavirus‐2 infection

Rosen, H. R., O'Connell, C. L., Nadim, M. K., DeClerck, B. K., Sheibani, S., DePasquale, E. C., Sanossian, N., Blodget, E., & Angell, T. E. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26595 · Cited by 13

Autopsy and statistical evidence of disturbed hemostasis progress in COVID-19: medical records from 407 patients

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