Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation: On behalf of the Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH)

Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study

Vincent, J.-L., de Mendonca, A., Cantraine, F., Moreno, R., Takala, J., Suter, P. M., Sprung, C. L., Colardyn, F., & Blecher, S. (1998) · Critical Care Medicine · doi:10.1097/00003246-199811000-00016 · Cited by 3,463

Disseminated Intravascular Coagulation

Levi, M. M., & Cate, H. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410807 · Cited by 2,035

Studies of the prothrombin activation pathway utilizing radioimmunoassays for the F2/F1 + 2 fragment and thrombin--antithrombin complex

Teitel, J., Bauer, K. A., Lau, H., & ROSENBERG, R. D. (1982) · Blood · doi:10.1182/blood.v59.5.1086.1086 · Cited by 264

Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Mie DIC Study Group.

Wada, H., Wakita, Y., Nakase, T., Shimura, M., Hiyoyama, K., Nagaya, S., Mori, Y., & Shiku, H. (1995) · PubMed · Cited by 156

Disseminated Intravascular Coagulation: Objective Clinical and Laboratory Diagnosis, Treatment, and Assessment of Therapeutic Response

Bick, R. L. (1996) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-998993 · Cited by 123

Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock

Gando, S., Nanzaki, S., Sasaki, S., Aoi, K., & Kemmotsu, O. (1998) · Critical Care Medicine · doi:10.1097/00003246-199812000-00030 · Cited by 112

Increased tissue factor pathway inhibitor in patients with acute myocardial infarction

Kamikura, Y., Wada, H., Yamada, A., Shimura, M., Hiyoyama, K., Shiku, H., Tanigawa, M., Nishikawa, H., Yamada, N., Isaka, N., et al. (1997) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199707)55:4 · Cited by 48

Studies on the inflammatory-coagulant axis in the baboon response to E. coli: regulatory roles of proteins C, S, C4bBP and of inhibitors of tissue factor.

Taylor, F. B. (1994) · PubMed · Cited by 39

Comparison of Immunological and Functional Assays for Measurement of Soluble Fibrin

Dempfle, C. ‐., Pfitzner, S. A., Dollman, M., Huck, K., Stehle, G., & Heene, D. L. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649796 · Cited by 37

Soluble fibrin: A predictor for the development and outcome of multiple organ failure

Bredbacka, S., Blombäck, M., & Wiman, B. (1994) · American Journal of Hematology · doi:10.1002/ajh.2830460407 · Cited by 28

Epidemiology of Critical Care Syndromes, Organ Failures, and Life-Support Interventions in a Suburban US Community

Cartin‐Ceba, R., Vukoja, M. K., Li, G., Kor, D. J., Poulose, J., Herasevich, V., Kashyap, R., Trillo‐Alvarez, C., Cabello-Garza, J., Hubmayr, R. D., et al. (2011) · CHEST Journal · doi:10.1378/chest.11-1197 · Cited by 54

Performance of D-dimer for predicting sepsis mortality in the intensive care unit

Han, Y., Zhang, L., Hu, Z.-D., Lippi, G., Li, P., Ouyang, P.-H., & Li, Y. (2021) · Biochemia Medica · doi:10.11613/bm.2021.020709 · Cited by 53

Endothelial activation predicts disseminated intravascular coagulopathy, cytokine release syndrome and prognosis in patients treated with anti‐CD19 CAR‐T cells

Galli, E., Sorà, F., Hohaus, S., Fresa, A., Pansini, I., Autore, F., Metafuni, E., Innocenti, I., Limongiello, M. A., Giammarco, S., et al. (2022) · British Journal of Haematology · doi:10.1111/bjh.18596 · Cited by 53

Enhanced Expression of Cell-Specific Surface Antigens on Endothelial Microparticles in Sepsis-Induced Disseminated Intravascular Coagulation

Matsumoto, H., Yamakawa, K., Ogura, H., Koh, T., Matsumoto, N., & Shimazu, T. (2015) · Shock · doi:10.1097/shk.0000000000000331 · Cited by 53

Prospective comparison of new Japanese Association for Acute Medicine (JAAM) DIC and International Society of Thrombosis and Hemostasis (ISTH) DIC score in critically ill septic patients

Singh, R., Baronia, A. K., Sahoo, J. N., Sharma, S., Naval, R., Pandey, C. M., Poddar, B., Azim, A., & Gurjar, M. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.11.017 · Cited by 53

Long-term Health Status in Childhood Survivors of Meningococcal Septic Shock

Buysse, C. M. P., Raat, H., Hazelzet, J. A., Hulst, J. M., Cransberg, K., Hop, W. C. J., Vermunt, L. C. A. C., Utens, E. M. W. J., Maliepaard, M., & Joosten, K. F. M. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.11.1036 · Cited by 53

Critical illness-associated cerebral microbleeds for patients with severe COVID-19: etiologic hypotheses

Lersy, F., Willaume, T., Brisset, J., Collange, O., Helms, J., Schneider, F., Chammas, A., Willaume, A., Meyer, N., Anheim, M., et al. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10313-8 · Cited by 54

Snakebite Associated Thrombotic Microangiopathy and Recommendations for Clinical Practice

Noutsos, T., Currie, B. J., Wijewickrama, E. S., & Isbister, G. K. (2022) · Toxins · doi:10.3390/toxins14010057 · Cited by 53

Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life

Buysse, C. M. P., Vermunt, L. C. A. C., Raat, H., Hazelzet, J. A., Hop, W. C. J., Utens, E. M. W. J., & Joosten, K. F. M. (2010) · Critical Care · doi:10.1186/cc9087 · Cited by 53

Utility of activated partial thromboplastin time waveform analysis for identification of sepsis and overt disseminated intravascular coagulation in patients admitted to a surgical intensive care unit

Dempfle, C.-E. H., Lorenz, S., Smolinski, M., Wurst, M., West, S., Houdijk, W. P. M., Quintel, M., & Borggrefe, M. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000110678.52863.f3 · Cited by 53

Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications

Curtiaud, A., Iba, T., Anglés‐Cano, E., Meziani, F., & Helms, J. (2025) · Annals of Intensive Care · doi:10.1186/s13613-025-01434-2 · Cited by 52

Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome― Fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction

Wada, T., Gando, S., Mizugaki, A., Yanagida, Y., Jesmin, S., Yokota, H., & Ieko, M. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.05.010 · Cited by 52

Disseminated Intravascular Coagulopathy in the First 24 Hours After Trauma: The Association Between ISTH Score and Anatomopathologic Evidence

Rizoli, S., Nascimento, B., Key, N. S., Tien, H. C. N., Muraca, S., Pinto, R. L., Khalifa, M., Plotkin, A., & Callum, J. L. (2011) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e318232e688 · Cited by 52

A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments

Kennedy, A. R., Maity, A. M., & Sanzari, J. K. (2016) · Radiation Research · doi:10.1667/rr14406.1 · Cited by 53

Plasma Endothelial Glycocalyx Components as a Potential Biomarker for Predicting the Development of Disseminated Intravascular Coagulation in Patients With Sepsis

Wang, X., Hu, H., Sun, T., Zhu, W., Tian, H., Dong, H., Wang, T., & Wang, X. (2020) · Journal of Intensive Care Medicine · doi:10.1177/0885066620949131 · Cited by 53

Coagulopathy and platelet disorders in critically ill patients.

Levi, M. M., & Schultz, M. J. (2010) · PubMed · Cited by 51

Assessment of the Interplay between Blood and Skin Vascular Abnormalities in Adult Purpura Fulminans

Lerolle, N., Carlotti, A., Melican, K., Aubey, F., Pierrot, M., Diehl, J., Caille, V., Hékimian, G., Gandrille, S., Mandet, C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0228oc · Cited by 51

Clinical Features of Coxsackievirus A4, B3 and B4 Infections in Children

Lee, C.-J., Huang, Y., Yang, S., Tsao, K., Chen, C., Hsieh, Y., Chiu, C.-H., & Lin, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087391 · Cited by 51

Usefulness of Measuring Changes in SOFA Score for the Prediction of 28-Day Mortality in Patients With Sepsis-Associated Disseminated Intravascular Coagulation

Iba, T., Arakawa, M., Mochizuki, K., Nishida, O., Wada, H., & Levy, J. H. (2019) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029618824044 · Cited by 51

Coagulation: Consultative Hemostasis

Hambleton, J., Leung, L. L. K., & Levi, M. M. (2002) · Hematology · doi:10.1182/asheducation-2002.1.335 · Cited by 51

Hemostatic alterations in COVID-19

Peyvandi, F., Artoni, A., Novembrino, C., Aliberti, S., Panigada, M., Boscarino, M., Gualtierotti, R., Rossi, F., Palla, R., Martinelli, I., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.262634 · Cited by 50

Serum miR-122 levels are related to coagulation disorders in sepsis patients

Wang, H., Deng, J., Wang, J.-Y., Zhang, P., Zhang, X., Xiao, K., Feng, D., Jia, Y., Liu, Y.-N., & Xie, L. (2014) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0899 · Cited by 50

Matrix Metalloproteinase-10 Is Upregulated by Thrombin in Endothelial Cells and Increased in Patients With Enhanced Thrombin Generation

Orbe, J., Rodríguez, J. A., Calvayrac, O., Rodríguez‐Calvo, R., Rodrı́guez, C., Roncal, C., de Lizarrondo, S. M., Barrenetxe, J., Reverter, J. C., Martínez‐González, J., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194589 · Cited by 50

Impact of recombinant soluble thrombomodulin (thrombomodulin alfa) on disseminated intravascular coagulation

Mimuro, J., Takahashi, H., Kitajima, I., Tsuji, H., Eguchi, Y., Matsushita, T., Kuroda, T., & Sakata, Y. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.03.008 · Cited by 50

Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases

Kawasugi, K., Wada, H., Hatada, T., Okamoto, K., Uchiyama, T., Kushimoto, S., Seki, Y., Okamura, T., & Nobori, T. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.02.015 · Cited by 50

Emergency peripartum hysterectomy: our 12-year experience

Şahin, S., Güzin, K., Eroğlu, M., Kayabaşoğlu, F., & Yaşartekin, M. S. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-013-3079-2 · Cited by 50

Changes in Plasma Levels of Natural Anticoagulants in Disseminated Intravascular Coagulation: High Prognostic Value of Antithrombin and Protein C in Patients with Underlying Sepsis or Severe Infection

Choi, Q., Hong, K. H., Kim, J.-E., & Kim, H. K. (2014) · Annals of Laboratory Medicine · doi:10.3343/alm.2014.34.2.85 · Cited by 50

Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury

Nguyen, T. C., Crúz, M. A., & Carcillo, J. A. (2015) · Critical Care Clinics · doi:10.1016/j.ccc.2015.06.004 · Cited by 50

Pre‐delivery fibrinogen predicts adverse maternal or neonatal outcomes in patients with placental abruption

Wang, L., Matsunaga, S., Mikami, Y., Takai, Y., Terui, K., & Seki, H. (2016) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12988 · Cited by 50

Thrombosis in adult patients with acute leukemia

Principe, M. I. D., Principe, D. D., & Venditti, A. (2017) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000402 · Cited by 49

Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin

Iba, T., Arakawa, M., Levy, J. H., Yamakawa, K., Koami, H., Hifumi, T., & Sato, K. (2018) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029618770273 · Cited by 50

Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation

Ikezoe, T., Takeuchi, A., Isaka, M., Arakawa, Y., Iwabu, N., Tsukuda, T. K., Anabuki, K., Sakai, M., Taniguchi, A., Togitani, K., et al. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.08.012 · Cited by 50

Reduced ADAMTS13 in children with severe meningococcal sepsis is associated with severity and outcome

Bongers, T. N., Emonts, M., de Maat, M. P. M., de Groot, R., Lisman, T., Hazelzet, J. A., & Leebeek, F. W. G. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-06-0376 · Cited by 50

Current Diagnostic Trends in Coagulation Disorders Among Dogs and Cats

Brooks, M. B., & Catalfamo, J. L. (2013) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2013.07.003 · Cited by 49

Asphyxia by Drowning Induces Massive Bleeding Due To Hyperfibrinolytic Disseminated Intravascular Coagulation

Schwameis, M., Schober, A., Schoergenhofer, C., Sperr, W. R., Schöchl, H., Janata‐Schwatczek, K., Kürkciyan, I. E., Sterz, F. R., & Jilma, B. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001273 · Cited by 49

Tissue factor-dependent and -independent pathways of systemic coagulation activation in acute myeloid leukemia: a single-center cohort study

Dicke, C., Amirkhosravi, A., Spath, B., Jiménez-Alcázar, M., Fuchs, T. A., Dávila, M., Francis, J. L., Bokemeyer, C., & Länger, F. P. (2015) · Experimental Hematology and Oncology · doi:10.1186/s40164-015-0018-x · Cited by 49

Prothrombin Complex Concentrate Is Effective in Treating the Anticoagulant Effects of Dabigatran in a Porcine Polytrauma Model

Honickel, M., Braunschweig, T. A., van Ryn, J., Cate, H. T., Spronk, H. M. H., Rossaint, R., & Grottke, O. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000863 · Cited by 49

Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation

Hyun, J., Kim, H. K., Kim, J.-E., Lim, M.-G., Jung, J. S., Park, S., & Cho, H. (2009) · Thrombosis Research · doi:10.1016/j.thromres.2008.11.020 · Cited by 49

A Novel Thromboelastographic Score to Identify Overt Disseminated Intravascular Coagulation Resulting in a Hypocoagulable State

Sharma, P., & Saxena, R. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcppz4j6cafydvm · Cited by 49

Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery

Sudo, A., Wada, H., Nobori, T., Yamada, N., Ito, M., Niimi, R., Hasegawa, M., Suzuki, K., & Uchida, A. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0323-4 · Cited by 49

Efficacy of antithrombin in preclinical and clinical applications for sepsis-associated disseminated intravascular coagulation

Iba, T., & Saitoh, D. (2014) · Journal of Intensive Care · doi:10.1186/s40560-014-0051-6 · Cited by 48

Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients

Wang, L., He, W., Yu, X., Hu, D., & Jiang, H. X. (2020) · World Journal of Clinical Cases · doi:10.12998/wjcc.v8.i19.4370 · Cited by 49

Elevated thrombopoietin in plasma of burned patients without and with sepsis enhances platelet activation

Lupia, E., Bosco, O., Mariano, F., Dondi, A. E., Goffi, A., Spatola, T., Cuccurullo, A., Tizzani, P., Brondino, G., Stella, M., et al. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03348.x · Cited by 48

Thrombin activatable fibrinolysis inhibitor is associated with severity and outcome of severe meningococcal infection in children

Emonts, M., de Bruijne, E. L. E., Guimarães, A. H. C., Declerck, P. J., Leebeek, F. W. G., de Maat, M. P. M., Rijken, D. C., Hazelzet, J. A., & Gils, A. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02841.x · Cited by 49

Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria. Comparison between sepsis and trauma.

Kushimoto, S., Gando, S., Saitoh, D., Ogura, H., Mayumi, T., Koseki, K., Ikeda, T., Ishikura, H., Iba, T., Ueyama, M., et al. (2008) · PubMed · Cited by 49

Thromboelastometry (TEM®) Findings in Disseminated Intravascular Coagulation in a Pig Model of Endotoxinemia

Schöchl, H., Solomon, C., Schulz, A., Voelckel, W., Hanke, A., van Griensven, M., Redl, H. R., & Bahrami, S. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00159 · Cited by 49

Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH

Wang, T., Makar, R. S. J., Antic, D. A., Levy, J. H., Douketis, J. D., Connors, J. M., Carrier, M., & Zwicker, J. I. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15074 · Cited by 48

Validation of sepsis-induced coagulopathy score in critically ill patients with septic shock: post hoc analysis of a nationwide multicenter observational study in Japan

Tanaka, C., Tagami, T., Kudo, S., Takehara, A., Fukuda, R., Nakayama, F., Kaneko, J., Ishiki, Y., Sato, S., Kuno, M., et al. (2021) · International journal of hematology · doi:10.1007/s12185-021-03152-4 · Cited by 46

SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock

Bunch, C. M., Chang, E., Moore, E. E., Moore, H. B., Kwaan, H. C., Miller, J. B., Al-Fadhl, M. D., Thomas, A. V., Zackariya, N., Patel, S. S., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1094845 · Cited by 48

Impact of hyper- and hypothermia on cellular and whole-body physiology

Iba, T., Kondo, Y., Maier, C. L., Helms, J., Ferrer, R., & Levy, J. H. (2025) · Journal of Intensive Care · doi:10.1186/s40560-024-00774-8 · Cited by 48

Does Disseminated Intravascular Coagulation Lead to Multiple Organ Failure?

Vincent, J., & Backer, D. D. (2005) · Critical Care Clinics · doi:10.1016/j.ccc.2005.04.002 · Cited by 48

Antiphospholipid antibodies in critically ill patients with cancer: A prospective cohort study

Vassalo, J., Spector, N., de Meis, E., Rabello, L. S., Rosolem, M. M., do Brasil, P. E. A. A., Salluh, J. I., & Soares, M. (2014) · Journal of Critical Care · doi:10.1016/j.jcrc.2014.02.005 · Cited by 50

Influenza A Infection Triggers Thrombotic Thrombocytopenic Purpura by Producing the Anti-ADAMTS13 IgG Inhibitor

Kosugi, N., Tsurutani, Y., Isonishi, A., Hori, Y., Matsumoto, M., & Fujimura, Y. (2010) · Internal Medicine · doi:10.2169/internalmedicine.49.2957 · Cited by 48

Development of a model based scoring system for diagnosis of canine disseminated intravascular coagulation with independent assessment of sensitivity and specificity

Wiinberg, B., Jensen, A. L., Johansson, P. I., Kjelgaard-Hansen, M. J., Rozanski, E. A., Tranholm, M., & Kristensen, A. T. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.06.003 · Cited by 49

Application of the Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria for patients at an early phase of trauma

Sawamura, A., Hayakawa, M., Gando, S., Kubota, N., Sugano, M., Wada, T., & Katabami, K. (2009) · Thrombosis Research · doi:10.1016/j.thromres.2009.06.036 · Cited by 48

Fresh frozen plasma in patients with disseminated intravascular coagulation or in patients with liver diseases

Mueller, M. M., Bomke, B., & Seifried, E. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00146-9 · Cited by 48

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with COVID-19

Gerotziafas, G., Sergentanis, T. Ν., Voiriot, G., Lassel, L., Papageorgiou, C., Elabbadi, A., Turpin, M., Dreden, P. V., Papageorgiou, L., Ψαλτοπούλου, Θ., et al. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1716544 · Cited by 46

Long-term health-related quality of life in survivors of meningococcal septic shock in childhood and their parents

Buysse, C. M. P., Raat, H., Hazelzet, J. A., Vermunt, L. C. A. C., Utens, E. M. W. J., Hop, W. C. J., & Joosten, K. F. M. (2007) · Quality of Life Research · doi:10.1007/s11136-007-9271-8 · Cited by 47

Animal models of DIC and their relevance to human DIC: A systematic review

Berthelsen, L. O., Kristensen, A. T., & Tranholm, M. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2010.12.002 · Cited by 46

Potential diagnostic markers for disseminated intravascular coagulation of sepsis

Iba, T., Ito, T., Maruyama, I., Jilma, B., Brenner, T., Müller, M. C. A., Juffermans, N. P., & Thachil, J. V. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.10.002 · Cited by 46

Activated platelet-derived microparticle numbers are elevated in patients with severe fungal ( Candida albicans ) sepsis

Woth, G., Tökés‐Füzesi, M., Magyarlaki, T., Kovács, G. L., Vermes, I., & Mühl, D. (2012) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2012.011215 · Cited by 47

Disseminated intravascular coagulation – new pathophysiological concepts and impact on management

Thachil, J. V. (2016) · Expert Review of Hematology · doi:10.1080/17474086.2016.1203250 · Cited by 46

Low D-dimer levels in sepsis: Good or bad?

Semeraro, F., Ammollo, C. T., Caironi, P., Masson, S., Latini, R., Panigada, M., Semeraro, N., Gattinoni, L., & Colucci, M. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.12.003 · Cited by 47

Hematological manifestations of COVID-19

Mina, A. A., van Besien, K., & Platanias, L. C. (2020) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2020.1788017 · Cited by 47

Comparison of Procedure-Based and Diagnosis-Based Identifications of Severe Sepsis and Disseminated Intravascular Coagulation in Administrative Data

Yamana, H., Horiguchi, H., Fushimi, K., & Yasunaga, H. (2016) · Journal of Epidemiology · doi:10.2188/jea.je20150286 · Cited by 46

Complement Activation in Human Sepsis is Related to Sepsis-Induced Disseminated Intravascular Coagulation

Abe, T., Kubo, K., Izumoto, S., Shimazu, S., Goan, A., Tanaka, T., Koroki, T., Saito, K., Kawana, R., & Ochiai, H. (2020) · Shock · doi:10.1097/shk.0000000000001504 · Cited by 46

Plasma exchange therapy for thrombotic microangiopathies

Nguyen, T. C., & Han, Y. Y. (2011) · Organogenesis · doi:10.4161/org.7.1.14027 · Cited by 46

Sepsis, Coagulation, and Antithrombin: Old Lessons and New Insights

Levi, M. M., Schouten, M., & van der Poll, T. (2008) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0029-1145256 · Cited by 49

Evaluation of haemostatic molecular markers for diagnosis of disseminated intravascular coagulation in patients with infections

Asakura, H., Okamoto, K., Iba, T., Uchiyama, T., Eguchi, Y., Kawasugi, K., Koga, S., Mayumi, T., Koike, K., Gando, S., et al. (2006) · Thrombosis and Haemostasis · doi:10.1160/th05-04-0286 · Cited by 46

Thrombin generation in severe sepsis

Petros, S., Kliem, P., Siegemund, T., & Siegemund, T. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.08.004 · Cited by 45

Thrombotic Microangiopathies (TTP, HUS, HELLP)

Kappler, S. B., Ronan-Bentle, S., & Graham, A. C. (2014) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2014.04.008 · Cited by 45

The anticoagulant therapy for sepsis-associated disseminated intravascular coagulation

Iba, T., Nagaoka, I., & Boulat, M. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.03.012 · Cited by 45

Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding

Moxon, C., Chisala, N. V., Mzikamanda, R., MacCormick, I. J. C., Harding, S. P., Downey, C., Molyneux, M. E., Seydel, K. B., Taylor, T. E., Heyderman, R. S., et al. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13060 · Cited by 45

A new perspective to determine the severity of cases with Crimean-Congo hemorrhagic fever

Engın, A., Bakır, M., Gözel, M. G., Elaldı, N., Kılıçkap, S., & Çınar, Z. (2012) · Journal of Vector Borne Diseases · doi:10.4103/0972-9062.213375 · Cited by 45

Reactive Hemophagocytic Syndrome in Adult Korean Patients with Systemic Lupus Erythematosus: A Case-Control Study and Literature Review

Kim, J., Kwok, S., Ju, J. H., Kim, H., & Park, S. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.110639 · Cited by 45

Thromboelastometry as a supplementary tool for evaluation of hemostasis in severe sepsis and septic shock

ANDERSEN, M. G., Hvas, C. L., Tønnesen, E., & Hvas, A. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12290 · Cited by 45

COVID-19 : physiopathologie d’une maladie à plusieurs visages

Bonny, V., Maillard, A., Mousseaux, C., Plaçais, L., & Richier, Q. (2020) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2020.05.003 · Cited by 61

Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer

Ota, S., Wada, H., Nobori, T., Kobayashi, T., Nishio, M. J., Nishioka, Y., Noda, M., Sakaguchi, A., Abe, Y., Nishioka, J., et al. (2005) · American Journal of Hematology · doi:10.1002/ajh.20396 · Cited by 45

Coagulation abnormalities in sepsis

Tsao, C., Ho, S.-T., & Wu, C. (2014) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2014.11.002 · Cited by 44

Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH)

Appelmann, I., Kreher, S., Parmentier, S. B., Wolf, H., Bisping, G., Kirschner, M., Bergmann, F., Schilling, K., Brümmendorf, T. H., Petrides, P. E., et al. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2621-2 · Cited by 45

DIC in obstetrics: Diagnostic score, highlights in management, and international registry‐communication from the DIC and Women's Health SSCs of the International Society of Thrombosis and Haemostasis

Rabinovich, A., Kadir, R. A., Thachil, J. V., Iba, T., Othman, M., & Erez, O. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14523 · Cited by 44

Activated protein C in sepsis: a critical review

Levi, M. M. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328304b3e3 · Cited by 43

Biomarkers of Platelet Activation and Their Prognostic Value in Patients With Sepsis-Associated Disseminated Intravascular Coagulopathy

Wegrzyn, G., Walborn, A., Rondina, M. T., Fareed, J., & Hoppensteadt, D. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029620943300 · Cited by 43

Coagulation Parameters and Risk of Progressive Hemorrhagic Injury after Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Zhang, D., Gong, S., Jin, H. D., Wang, J., Sheng, P. X., Zou, W., Dong, Y., & Hou, L. (2015) · BioMed Research International · doi:10.1155/2015/261825 · Cited by 43

Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic Escherichia coli Shiga Toxins in Non-Human Primate Models of Hemolytic Uremic Syndrome

Stearns-Kurosawa, D. J., Oh, S., Cherla, R. P., Lee, M., Tesh, V. L., Papin, J. F., Henderson, J., & Kurosawa, S. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.026 · Cited by 43

Gastric cancer with initial bone metastasis: A distinct group of diseases with poor prognosis

Kim, Y. J., Kim, S. H., Kim, J. W., Lee, J., Kim, J. H., Bang, S., Lee, J. S., & Lee, K. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.08.003 · Cited by 43

Neutrophil Fluorescence: A New Indicator of Cell Activation During Septic Shock–Induced Disseminated Intravascular Coagulation

Stiel, L., Delabranche, X., Galoisy, A.-C., Séverac, F., Toti, F., Mauvieux, L., Meziani, F., & Helms, J. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001851 · Cited by 43

Septic Pulmonary Embolism Requiring Critical Care: Clinicoradiological Spectrum, Causative Pathogens and Outcomes

Chou, D.-W., Wu, S., Chung, K.-M., Han, S.-C., & Cheung, B. M.-H. (2016) · Clinics · doi:10.6061/clinics/2016(10)02 · Cited by 43

Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS‑induced sepsis

Wang, X., Han, S., Liu, X., Wang, T., Xu, H., Xia, B., Kong, G., Li, J., Zhu, W., Hu, H., et al. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8285 · Cited by 46

Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions

Minno, M. N. D. D., Calcaterra, I. L., Lupoli, R., Storino, A., Spedicato, G. A., Maniscalco, M., Minno, A. D., & Ambrosino, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072244 · Cited by 43

Underlying disorders of disseminated intravascular coagulation: Communication from the ISTH SSC Subcommittees on Disseminated Intravascular Coagulation and Perioperative and Critical Care Thrombosis and Hemostasis

Squizzato, A., Gallo, A., Levi, M. M., Iba, T., Levy, J. H., Erez, O., Cate, H. T., Solh, Z., Gando, S., Vicente, V., et al. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14946 · Cited by 43

Coagulation and Fibrinolysis in Inflammatory Bowel Disease and in Giant Cell Arteritis

Vrij, A. A., Rijken, J., van Wersch, J. W. J., & Stockbrügger, R. W. (2003) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000073850 · Cited by 43

Treatment of adult patients with sepsis‐induced coagulopathy and purpura fulminans using a plasma‐derived protein C concentrate (Ceprotin®)

Schellongowski, P., Bauer, E., Holzinger, U., Staudinger, T., Frass, M., Laczika, K. F., Locker, G. J., Quehenberger, P., Rabitsch, W., Schenk, P., et al. (2006) · Vox Sanguinis · doi:10.1111/j.1423-0410.2006.00760.x · Cited by 43

Analytic Validation and Clinical Evaluation of the STA LIATEST Immunoturbidimetric D-Dimer Assay for the Diagnosis of Disseminated Intravascular Coagulation

Lehman, C. M., Wilson, L. W., & Wilson, L. W. (2004) · American Journal of Clinical Pathology · doi:10.1309/x4yn-001g-u51n-gg9y · Cited by 43

Mycobacterium tuberculosis inducing disseminated intravascular coagulation

Wang, J., Hsueh, P., Liaw, Y., Shau, W., Yang, P., Luh, K., & Lee, L. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-09-0562 · Cited by 43

Therapeutic Plasma Exchange Protects Patients with Sepsis-Associated Disseminated Intravascular Coagulation by Improving Endothelial Function

Weng, J., Chen, M., Fang, D., Liu, D., Guo, R., & Yang, S. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211053313 · Cited by 42

Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series

Peetermans, M., Matheeussen, V., Moerman, C., Rydt, F. D., Thieren, S., Pollet, E., Casaer, M. P., Backer, B. D., Paep, R. D., Debaveye, Y. A., et al. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01249-7 · Cited by 42

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024

Shime, N., Nakada, T.-A., Yatabe, T., Yamakawa, K., Aoki, Y., Inoue, S., Iba, T., Ogura, H., Kawai, Y., Kawaguchi, A., et al. (2025) · Journal of Intensive Care · doi:10.1186/s40560-025-00776-0 · Cited by 45

Fraction of immature granulocytes reflects severity but not mortality in sepsis

Ha, S. O., Park, S. H., Park, S. H., Park, J.-S., Huh, J. W., Lim, C., Koh, Y., Hong, S., & Jang, S. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.965736 · Cited by 42

APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial

Pettilä, V., Kyhälä, L., Kylänpää, M., Leppäniemi, A. K., Tallgren, M. K., Markkola, A. T., Puolakkainen, P. A., Repo, H., & Kemppainen, E. (2010) · Critical Care · doi:10.1186/cc9203 · Cited by 42

Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation

Taylor, F. J. (2001) · Thrombosis and Haemostasis · Cited by 175

Towards Definition, Clinical and Laboratory Criteria, and a Scoring System for Disseminated Intravascular Coagulation* On behalf of the Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the ISTH

Taylor, F. B., Toh, C., Hoots, W. K., Wada, H., & Levi, M. M. (2001) · Thrombosis and Haemostasis · Cited by 39

State-of-the-Art Review : Disseminated Intravascular Coagulation: Objective Criteria for Clinical and Laboratory Diagnosis and Assessment of Therapeutic Response

Bick, R. L. (1995) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602969500100103 · Cited by 24

Title A Prospective Comparative Study of Three Sets of Criteria for Disseminated Intravascular Coagulation. ISTH Criteria vs. Japanese Criteria

Hoshino, H., & Md, M. H. (2015)

Prospective Validation of the International Society of Thrombosis and Haemostasis Scoring System for, Disseminated Intravascular Coagulation

Kobeissi, Z. A., & Zanotti-Cavazzoni, S. L. (2006) · Yearbook of Critical Care Medicine · doi:10.1016/s0734-3299(08)70146-1 · Cited by 1