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The Relationship of Antiphospholipid Antibodies to Thromboembolic Disease in Systemic Lupus Erythematosus: A Cross-Sectional Study
Abstract
In order to determine whether an association exists between antiphospholipid antibodies (APLA) and thromboembolic events in patients with systemic lupus erythematosus (SLE), we performed a cross-sectional study of consecutive unselected SLE patients. The occurrence of previous thromboembolic events was determined by investigators blinded to the APLA status of the patients by critical review of objective tests that had been performed at the time of symptomatic presentation and by performing venous Doppler ultrasound of the legs to elicit venous reflux as an indication of previous venous thrombosis. The presence of APLA was determined by coagulation assays for the lupus anticoagulant (LA) using five tests with well-defined control ranges and by ELISA assay for anticardiolipin antibodies (ACLA). These tests were measured on two separate occasions. The results of the study demonstrate a statistically significant association between persistently abnormal ACLA assays and thromboembolic events and a non-significant trend between persistently abnormal LA and thromboembolic events. Transient abnormalities of LA and ACLA were less strongly associated with thromboembolic events. We conclude that in patients with SLE, there is a significant association between thromboembolism and APLA.
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“Even in the absence of antiphospholipid antibodies, patients with SLE have an increased risk of thromboembolic events.3”
From Evaluation of different ways to identify persistent positivity of lupus anticoagulant in systemic lupus erythematosus (2020) · cites this paper as [3]
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Management of Patients with Antiphospholipid Antibodies
Alving, B. M. (1994) · Springer eBooks · doi:10.1007/978-3-642-79009-6_29 · Cited by 1
“event compared to those who test positive for anti phospholipid antibodies on only one occasion [14, 20].”
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Axford, J. S., Watts, R. A., Long, A. A., et al. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2415-1_25 · Cited by 1
Self-citationGinsberg, J., Demers, C., Brill-Edwards, P. A., et al. (1993) · Blood · doi:10.1182/blood.v81.11.2958.bloodjournal81112958 · Cited by 1
Self-citationMolekulare Grundlagen von Thrombose und Embolie in der Schwangerschaft
Zotz, R. B., Gerhardt, A., & Scharf, R. E. (2002) · Steinkopff eBooks · doi:10.1007/978-3-642-57533-4_9
Lupus eritematoso sistémico y eventos trombóticos en un hospital terciario
Oropesa, R., Catalá, J. C., Fernández, C. C., et al. (2007) · Dialnet (Universidad de la Rioja)
Gender Issues in Venous Thromboembolism
Murin, S., Bilello, K. L., Moores, L. K., & Holley, A. B. (2010) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-374271-1.00020-4
Thrombophilias and pre-eclampsia
Walker, I. D. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545634.022
Bounameaux, C. (2008) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:597
Venous Thromboembolism: Gender Effects and Gender-Specific Risk Factors for Women
Murin, S., Moores, L. K., Bilello, K. L., & Matthay, R. A. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50299-1
Fiabilidad de los tests diagnósticos no invasivos en la recurrencia de la trombosis venosa profunda
Fontcuberta-García, J. M., Leal, I., Flores-Herrero, A., et al. (2007) · Angiología · doi:10.1016/s0003-3170(07)75039-3
Yasuhara, H., & Muto, T. (2000) · Phlebology The Journal of Venous Disease · doi:10.1177/026835550001500207
Zanon, E., Simioni, P., Saracino, M. A., Prandoni, P., Girolami, B., Sardella, C., & Girolami, A. (1997) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602969700300303
Anticoagulation Therapy in Pregnant Patients
Savella, S., Kvasic, J., & Lau, J. F. (2018) · Springer eBooks · doi:10.1007/978-3-319-73709-6_18
Bates, S. M. (2009) · Fundamental and clinical cardiology · doi:10.3109/9781420069242.012
Liebman, H. A., & Weitz, I. C. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5223-4.00037-8
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Antiphospholipid Antibody Syndrome
Zambon, M., Cappelli, D., & Berlot, G. (2012) · Springer eBooks · doi:10.1007/978-88-470-2448-9_13
Skin involvement in other autoimmune diseases
Xu, Y., Tian, J., Chen, J., Hu, Q., & Zhu, H. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00062-x
Mishra, R. K., Kavadichanda, C. G., Baskaran, P., Philip, S., Naushad, R., Mohapatra, S., Rajendran, M., Kalidass, K., Gopal, A., Mariaselvam, C. M., et al. (2026) · Rheumatology · doi:10.1093/rheumatology/keag407
Atherogenesis and atherosclerosis in primary antiphospholipid syndrome
Ames, P. R. J. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Metadata
- Authors
- Long, A. A., Ginsberg, J. S., Brill-Edwards, P., Johnston, M., Turner, C., Denburg, J. A., Bensen, W. G., Cividino, A., Andrew, M., & Hirsh, J.
- Affiliations
- McMaster University (CA)
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1991
- Volume
- 66
- Issue
- 05
- Pages
- 520-524
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2462341569
- Cited by
- 120
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 1 · 2013: 7 · 2012: 2
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- antiphospholipid antibodies, systemic lupus erythematosus, thromboembolism, lupus anticoagulant, anticardiolipin antibodies, venous thrombosis, venous Doppler ultrasound, thrombosis risk factors
- MeSH terms
- Autoantibodies, Blood Coagulation Tests, Humans, Lupus Erythematosus, Systemic, Partial Thromboplastin Time, Phospholipids, Thromboembolism, Factor Xa
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