Criteria for the Diagnosis of Lupus Anticoagulants: An Update: On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH

Do antiphospholipid antibodies increase the long-term risk of thrombotic complications in young patients with a recent TIA or ischemic stroke?

van Goor, M. P. J., Alblas, C. L., Leebeek, F. W. G., Koudstaal, P. J., & Dippel, D. W. J. (2004) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2004.00241.x · Cited by 42

Neurometabolic changes in normal white matter may predict appearance of hyperintense lesions in systemic lupus erythematosus

Appenzeller, S., Li, L. M., Costallat, L. T. L., & Cendes, F. (2007) · Lupus · doi:10.1177/0961203307084723 · Cited by 43

The G1691 → A mutation of factor V, but not the G20210 → A mutation of factor II or the C677 → T mutation of methylenetetrahydrofolate reductase genes, is associated with venous thrombosis in patients with lupus anticoagulants

Galli, M., Finazzi, G., Duca, F., et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01964.x · Cited by 43

Clinical Implications of Migraine in Systemic Lupus Erythematosus: Relation to Cumulative Organ Damage

Appenzeller, S., & Costallat, L. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00785.x · Cited by 43

No more mixing tests required for integrated assay systems in the laboratory diagnosis of lupus anticoagulants?

DEVREESE, K. M. J. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03807.x · Cited by 42

Commonalities and contrasts in recent guidelines for lupus anticoagulant detection

Moore, G. W. (2014) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12227 · Cited by 41

Thrombophilia in 67 Patients With Thrombotic Events After Starting Testosterone Therapy

Glueck, C. J., Prince, M., Patel, N., Patel, J., Shah, P. K., Mehta, N., & Wang, P. (2015) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029615619486 · Cited by 41

Antiprothrombin antibodies—are they worth assaying?

Atsumi, T., Amengual, O., Yasuda, S., et al. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.08.024 · Cited by 42

Testosterone, thrombophilia, thrombosis

Freedman, J., Glueck, C. J., Prince, M., Riaz, R., & Wang, P. (2015) · Translational research · doi:10.1016/j.trsl.2014.12.003 · Cited by 41

Subclinical right ventricle systolic dysfunction in childhood-onset systemic lupus erythematosus: insights from two-dimensional speckle-tracking echocardiography

Leal, G. N., Silva, K. F., França, C. M. P., Lianza, A. C., Andrade, J. L., Campos, L. M. A., Bonfá, E., & Silva, C. A. (2014) · Lupus · doi:10.1177/0961203314563135 · Cited by 41

Intractable Headaches, Ischemic Stroke, and Seizures Are Linked to the Presence of Anti-β2GPI Antibodies in Patients with Systemic Lupus Erythematosus

Hawro, T., Bogucki, A., Krupińska-Kun, M., Maurer, M., & Woźniacka, A. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119911 · Cited by 41

Prediction of Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus

dos Reis, C. R. P., Cardoso, G., de Carvalho, C. A., et al. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08762-9 · Cited by 41

Antiphospholipid Syndrome

Keswani, S. C., & Chauhan, N. (2002) · Journal of the Royal Society of Medicine · doi:10.1177/014107680209500705 · Cited by 48

Testing for lupus anticoagulants: all that a clinician should know

Tripodi, A. (2009) · Lupus · doi:10.1177/0961203308101436 · Cited by 41

Diagnosis of antiphospholipid syndrome

Bertolaccini, M. L., Khamashta, M. A., & Hughes, G. R. V. (2005) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0017 · Cited by 40

CLASSIFICATION CRITERIA FOR ANTIPHOSPHOLIPID SYNDROME

Wilson, W. A. (2001) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70216-7 · Cited by 41

Value of IgA anticardiolipin and anti-β2-glycoprotein I antibody testing in patients with pregnancy morbidity

Carmo-Pereira, S., Bertolaccini, M. L., Escudero‐Contreras, A., Khamashta, M. A., & Hughes, G. R. V. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.6.540 · Cited by 41

European attempts for the standardisation of the antiphospholipid antibodies

Tincani, A., Filippini, M., Scarsi, M., Galli, M., & Meroni, P. L. (2009) · Lupus · doi:10.1177/0961203309106919 · Cited by 40

Pregnancy and thrombophilia

Patnaik, M. M., Haddad, T. C., & Morton, C. T. (2007) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.5.4.753 · Cited by 40

Macrophage activation syndrome: A severe and frequent manifestation of acute pancreatitis in 362 childhood-onset compared to 1830 adult-onset systemic lupus erythematosus patients

Gormezano, N. W. S., Otsuzi, C. I., Barros, D. L., da Silva, M. A., Pereira, R. M. R., Campos, L. M. A., Borba, E. F., Bonfá, E., & Silva, C. A. (2015) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2015.10.015 · Cited by 41

Testosterone Therapy, Thrombophilia, Venous Thromboembolism, and Thrombotic Events

Glueck, C. J., Goldenberg, N., & Wang, P. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm8010011 · Cited by 41

Antiplatelet Factor 4—Heparin Antibodies in Patients with Antiphospholipid Antibodies

Martinuzzo, M. E., Forastiero, R. R., Adamczuk, Y., et al. (1999) · Thrombosis Research · doi:10.1016/s0049-3848(99)00057-2 · Cited by 40

ANTIPHOSPHOLIPID (HUGHES) SYNDROME IN SYSTEMIC LUPUS ERYTHEMATOSUS

Amigo, M., & Khamashta, M. A. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70141-1 · Cited by 39

Antiphospholipid antibodies (APLA) in immune thrombocytopenic purpura (ITP) and antiphospholipid syndrome (APS)

Bidot, C., Jy, W., Horstman, L. L., et al. (2006) · American Journal of Hematology · doi:10.1002/ajh.20571 · Cited by 40

Antibodies to tissue‐type plasminogen activator in plasma from patients with primary antiphospholipid syndrome

Cugno, M., Domínguez, M., Cabibbe, M., Bisiani, G., Galli, M., Anglés‐Cano, E., & Agostoni, A. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01948.x · Cited by 39

Normal plasma mixing studies in the laboratory diagnosis of lupus anticoagulant

Thom, J., Ivey, L., & Eikelboom, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2003.0543h.x · Cited by 38

Double heterozygosity polymorphisms for platelet glycoproteins Ia/IIa and IIb/IIIa increases arterial thrombosis and arteriosclerosis in patients with the antiphospholipid syndrome or with systemic lupus erythematosus

Jiménez, S., Tàssies, D., Espinosa, G., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.077321 · Cited by 39

Hematocrit and the Risk of Recurrent Venous Thrombosis: A Prospective Cohort Study

Eischer, L., Tscholl, V., Heinze, G., Traby, L., Kyrle, P. A., & Eichinger, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038705 · Cited by 39

Etiology and VTE risk factor distribution in patients with inferior vena cava thrombosis

Linnemann, B., Schmidt, H., Schindewolf, M., et al. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.01.004 · Cited by 39

Pediatric Antiphospholipid Syndrome

Aguiar, C. L., Soybilgic, A., Avčin, T., & Myones, B. L. (2015) · Current Rheumatology Reports · doi:10.1007/s11926-015-0504-5 · Cited by 39

The Prevalence of Bleeding Disorders Among Healthy Pediatric Patients With Abnormal Preprocedural Coagulation Studies

Shaw, P. H., Reynolds, S. L., Gunawardena, S. W., et al. (2008) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e31815d8915 · Cited by 39

Anti-lysobisphosphatidic acid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus

Alessandri, C., Bombardieri, M., Prospero, L. D., Conigliaro, P., Conti, F., Labbadia, G., Misasi, R., Sorice, M., & Valesini, G. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02727.x · Cited by 38

The Influence of Developmental Haemostasis on the Laboratory Diagnosis and Management of Haemostatic Disorders During Infancy and Childhood

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High levels of antiphospholipid antibodies are associated with cytomegalovirus infection in unrelated bone marrow and cord blood allogeneic stem cell transplantation

Mengarelli, A., Minotti, C., Palumbo, G., et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01812.x · Cited by 39

Antiphospholipid Syndrome

Ravelli, A., & Martini, A. (2005) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2005.01.001 · Cited by 40

Prolonged APTT of unknown etiology: A systematic evaluation of causes and laboratory resource use in an outpatient hemostasis academic unit

Barbosa, A. C. N., Montalvão, S. A. D. L., Barbosa, K. G. N., Colella, M. P., Annichino‐Bizzacchi, J. M., Ozelo, M. C., & Paula, E. V. D. (2019) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12252 · Cited by 36

Cerebral and Cerebellar Volume Loss in Children and Adolescents with Systemic Lupus Erythematosus: A Review of Clinically Acquired Brain Magnetic Resonance Imaging

Muscal, E., Traipe, E., de Guzman, M. M., Myones, B. L., Brey, R. L., & Hunter, J. V. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.090983 · Cited by 38

Hgh prevalence of antibodies to platelet factor 4 heparin in patients with antiphospholipid antibodies in absence of heparin-induced thrombocytopenia

Martin‐Toutain, I., Pietté, J. C., Diemert, M.-C., et al. (2007) · Lupus · doi:10.1177/0961203306075562 · Cited by 38

Human reproductive failure is not a clinical feature associated with β2 glycoprotein-I antibodies in anticardiolipin and lupus anticoagulant seronegative patients (the antiphospholipid/cofactor syndrome)

Balasch, J., Reverter, J. C., Creus, M. T., Tàssies, D., Fábregues, F., Carmona, F., Font, J., & Vanrell, J. A. (1999) · Human Reproduction · doi:10.1093/humrep/14.8.1956 · Cited by 36

Effects of statins on thrombosis development in patients with systemic lupus erythematosus and antiphospholipid antibodies

Watanabe, T., Oku, K., Amengual, O., Hisada, R., Ohmura, K., Nakagawa, I., Shida, H., Bohgaki, T., Horita, T., Yasuda, S., et al. (2017) · Lupus · doi:10.1177/0961203317716787 · Cited by 38

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

Kremers, R., Zuily, S., Kelchtermans, H., Peters, T. C., Bloemen, S., Regnault, V., Hemker, H. C., de Groot, P. G., Wahl, D. G., & de Laat, B. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018018036 · Cited by 38

Anti-β2-Glycoprotein I Antibodies in Patients with Acute Venous Thromboembolism

Zanon, E., Prandoni, P., Vianello, F., Saggiorato, G., Carraro, G., Bagatella, P., & Girolami, A. (1999) · Thrombosis Research · doi:10.1016/s0049-3848(99)00105-x · Cited by 38

Lupus anticoagulants and anti‐phospholipid antibodies as risk factors for a first episode of ischemic stroke

SAIDI, S., MAHJOUB, T., & ALMAWI, W. Y. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03446.x · Cited by 37

The effects of phosphatidylserine‐dependent antiprothrombin antibody on thrombin generation

Sakai, Y., Atsumi, T., Ieko, M., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24708 · Cited by 37

Neurologic manifestations of the antiphospholipid syndrome: Integrating molecular and clinical lessons

Muscal, E., & Brey, R. L. (2008) · Current Rheumatology Reports · doi:10.1007/s11926-008-0012-y · Cited by 37

Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting

Wong, R. C. W., Favaloro, E. J., Adelstein, S., Baumgart, K. W., Bird, R. J., Brighton, T., Empson, M. B., Gillis, D., Hendle, M. J., Laurent, R., et al. (2007) · Pathology · doi:10.1080/00313020701717720 · Cited by 37

YKL-40 in giant cells and macrophages from patients with giant cell arteritis

Johansen, J. S., Baslund, B., Garbarsch, C., Hansen, M. S., Stoltenberg, M., Lorenzen, I., & Price, P. A. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199912)42:12 · Cited by 92

Recent insights into antiphospholipid antibody-mediated thrombosis

Field, S. L., Brighton, T., McNeil, H. P., & Chesterman, C. N. (1999) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.1999.0033 · Cited by 34

Pregnancy outcome in women with antiphospholipid antibodies: report on a retrospective study

Heilmann, L., Schorch, M., Hahn, T., Adasz, G., Schilberz, K., Adiguzel, C., & Fareed, J. (2008) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0029-1145261 · Cited by 35

Monitoring anticoagulant therapy with vitamin K antagonists in patients with antiphospholipid syndrome

Isert, M., Miesbach, W., Schüttfort, G., Weil, Y., Tirneci, V., Kasper, A., Weber, A., Lindhoff‐Last, E., Herrmann, E. M., & Linnemann, B. (2015) · Annals of Hematology · doi:10.1007/s00277-015-2374-3 · Cited by 35

The Influence of the 1997 Updated Classification Criteria for Systemic Lupus Erythematosus: Epidemiology, Disease Presentation, and Patient Management

Eilertsen, G. Ø., Becker-Merok, A., & Nossent, J. C. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080574 · Cited by 36

Current Controversies in Lupus Anticoagulant Detection

Moore, G. (2016) · Antibodies · doi:10.3390/antib5040022 · Cited by 36

The risk of ischaemic stroke in primary antiphospholipid syndrome patients: a prospective study

Radin, M., Schreiber, K. I., Cecchi, I., Roccatello, D., Cuadrado, M. J., & Sciascia, S. (2017) · European Journal of Neurology · doi:10.1111/ene.13499 · Cited by 35

Testing for antiphospholipid antibodies: Advances and best practices

Devreese, K. M. J. (2020) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.13195 · Cited by 39

Low Preconception Complement Levels Are Associated with Adverse Pregnancy Outcomes in a Multicenter Study of 260 Pregnancies in 197 Women with Antiphospholipid Syndrome or Carriers of Antiphospholipid Antibodies

Nalli, C., Lini, D., Andréoli, L., Crisafulli, F., Fredi, M., Lazzaroni, M. G., Bitsadze, V., Calligaro, A., Canti, V., Caporali, R. F., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9060671 · Cited by 37

Lupus anticoagulant: performance of the tests as recommended by the latest ISTH guidelines

Swadźba, J., Iwaniec, T., PULKA, M., de Laat, B., de Groot, P. G., & Musiał, J. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04420.x · Cited by 36

Clinical and immunological features of 888 Brazilian systemic lupus patients from a monocentric cohort: comparison with other populations

Borba, E. F., Araujo, D., Bonfá, E., & Shinjo, S. K. (2013) · Lupus · doi:10.1177/0961203313490432 · Cited by 36

Prevalence of antiphospholipid antibodies in patients with neurological symptoms

Miesbach, W., Gilzinger, A., Gökpinar, B., Claus, D., & Scharrer, I. (2005) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2005.03.005 · Cited by 36

Reduced Free Protein S Levels in Patients with Inflammatory Bowel Disease

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Antiphospholipid Antibodies in Children without and in Adults with and without Thrombophilia

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VENOUS THROMBOEMBOLIC EVENTS IN PEDIATRIC PATIENTS

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Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays

Favaloro, E. J., & Wong, R. C. W. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.064 · Cited by 36

Deep venous thrombosis in the antenatal period in a large cohort of pregnancies from western India

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Dilute Russell's viper venom time reagents in lupus anticoagulant testing: a well‐considered choice

Depreter, B., & Devreese, K. M. J. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0245 · Cited by 34

Autoantibodies against phosphatidylserine, prothrombin and phosphatidylserine–prothrombin complex: Identical or distinct diagnostic tools for antiphospholipid syndrome?

Jaskowski, T. D., Wilson, A. R., Hill, H. R., et al. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.09.006 · Cited by 34

Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus

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Autoantibodies against a complement component 1 q subcomponent contribute to complement activation and recurrent thrombosis/pregnancy morbidity in anti-phospholipid syndrome

Oku, K., Amengual, O., Hisada, R., Ohmura, K., Nakagawa, I., Watanabe, T., Bohgaki, T., Horita, T., Yasuda, S., & Atsumi, T. (2016) · Rheumatology · doi:10.1093/rheumatology/kew196 · Cited by 33

Antiphospholipid Antibody Syndrome

Sangle, N. A., & Smock, K. J. (2011) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2010-0325-rsr.1 · Cited by 34

Echocardiography at diagnosis of antiphospholipid syndrome provides prognostic information on valvular disease evolution and identifies two subtypes of patients

Pardos‐Gea, J., Ordi‐Ros, J., Avegliano, G. P., Cortés-Hernández, J., Balada, E., Evangelista, A., & Vilardell, M. (2010) · Lupus · doi:10.1177/0961203309353772 · Cited by 34

Antiphosphatidylethanolamine antibodies contribute to the diagnosis of antiphospholipid syndrome in patients with systemic lupus erythematosus

Ordi‐Ros, J. (2001) · Scandinavian Journal of Rheumatology · doi:10.1080/030097401316909594 · Cited by 34

Lupus Antibody Bivalency Is Required to Enhance Prothrombin Binding to Phospholipid

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Plasma Levels of Activated Protein C in Healthy Subjects and Patients With Previous Venous Thromboembolism

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Clinical relevance of multiple antibody specificity testing in anti-phospholipid syndrome and recurrent pregnancy loss

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Independent validation of the antiphospholipid score for the diagnosis of antiphospholipid syndrome

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Thrombotic Microangiopathic Hemolytic Anemia With Reduction of ADAMTS13 Activity

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Pancreatitis Subtypes Survey in 852 Childhood‐Onset Systemic Lupus Erythematosus Patients

Marques, V. L. S., Gormezano, N. W. S., Bonfá, E., Aikawa, N. E., Terreri, M. T., Pereira, R. M. R., Magalhães, C. S., Guariento, A., Appenzeller, S., Ferriani, V. P. L., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000990 · Cited by 33

Stroke and antiphospholipid syndrome—antiphospholipid antibodies are a risk factor for an ischemic cerebrovascular event

Gašperšič, N., Zaletel, M., Kobal, J., Žigon, P., Čučnik, S., Šemrl, S. S., Tomšič, M., & Ambrožič, A. (2018) · Clinical Rheumatology · doi:10.1007/s10067-018-4247-3 · Cited by 33

The clinical manifestations and survival of systemic lupus erythematosus patients in Turkey: report from two centers

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Antiphospholipid antibiodies: a critical review of the literature

Lim, W., & Crowther, M. A. (2007) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282a4a65f · Cited by 32

Differences in lupus anticoagulant final conclusion through clotting time or Rosner index for mixing test interpretation

Depreter, B., & Devreese, K. M. J. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-0978 · Cited by 34

Testing for and Clinical Significance of Anticardiolipin Antibodies

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Autoantibodies against phosphatidylserine-prothrombin complex in patients with systemic sclerosis

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Long-term follow-up of antiphospholipid syndrome: real-life experience from a single center

Serrano, R., Pons‐Estel, G., Espinosa, G., Quintana, R., Reverter, J. C., Tàssies, D., Monteagudo, J., & Cervera, R. (2020) · Lupus · doi:10.1177/0961203320933009 · Cited by 31

Cardiac manifestations other than valvulopathy in antiphospholipid syndrome: long-time echocardiography follow-up study

Pardos‐Gea, J., Avegliano, G. P., Evangelista, A., Vilardell, M., & Ordi, J. (2013) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12191 · Cited by 32

How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review

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Impaired brachial endothelial function in patients with primary anti-phospholipid syndrome

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Combining Taipan snake venom time/Ecarin time screening with the mixing studies of conventional assays increases detection rates of lupus anticoagulants in orally anticoagulated patients

Moore, G. W. (2007) · Thrombosis Journal · doi:10.1186/1477-9560-5-12 · Cited by 32

Association of HLA-DM polymorphism with the production of antiphospholipid antibodies

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Prolonged remission is associated with a reduced risk of cardiovascular disease in patients with systemic lupus erythematosus: a GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

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The prevalence and clinical significance of inherited thrombophilic risk factors in patients with antiphospholipid syndrome

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Persistent thrombocytopenia predicts poor long-term survival in patients with antiphospholipid syndrome: a 38-year follow-up study

Pardos‐Gea, J., Marques-Soares, J. R., Buján, S., Ordi, J., & Alijotas‐Reig, J. (2021) · Rheumatology · doi:10.1093/rheumatology/keab475 · Cited by 31

Cystic fibrosis as a risk factor for recurrent venous thrombosis at a pediatric tertiary care hospital

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