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The Nijmegen Modification of the Bethesda Assay for Factor VIII:C Inhibitors: Improved Specificity and Reliability
Open accessAbstract
Summary: Antibodies against factor VIII coagulant activity can appear in haemophiliacs who are treated with factor VIII preparations but also spontaneously in non-haemophiliacs. The Bethesda assay is the most commonly used method to detect these antibodies, but it lacks specificity especially in the lower range resulting in unreliable data. Two modifications are proposed and tested to resolve the imperfections: 1. Buffering the normal plasma used in the assay- and control mixture with 0.1 M imidazole to pH 7.4. Replacing the imidazole buffer in the control mixture by immunodepleted factor VIII deficient plasma. These modifications allow better discrimination between positive and negative samples and improve reliability.
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Lusher, J. M., Arkin, S., Abildgaard, C. F., & Schwartz, R. S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302183280701 · Cited by 476
Cited by
International Recommendations on the Diagnosis and Treatment of Acquired Hemophilia A
Tiede, A., Collins, P., Knoebl, P., Teitel, J., Kessler, C., Shima, M., Di Minno, G., d’Oiron, R., Salaj, P., Jiménez-Yuste, V., et al. (2020) · Haematologica · doi:10.3324/haematol.2019.230771 · Cited by 401
VALENTINO, L. A., MAMONOV, V., HELLMANN, A., QUON, D. V., CHYBICKA, A., SCHROTH, P., PATRONE, L., & WONG, W. ‐. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04611.x · Cited by 253
Laboratory Diagnosis of Acquired Hemophilia A: Limitations, Consequences, and Challenges
Werwitzke, S., Scharf, R., & Tiede, A. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1390004 · Cited by 114
Tripodi, A., Mancuso, M. E., Chantarangkul, V., Clerici, M., Bader, R., Meroni, P. L., Santagostino, E., & Mannucci, P. M. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.054312 · Cited by 44
Shetty, S., Ghosh, K., & Mohanty, D. (2003) · Acta Haematologica · doi:10.1159/000067272 · Cited by 30
Metadata
- Authors
- Verbruggen, B., Novakova, I., Wessels, H., Boezeman, J., van den Berg, M., & Mauser-Bunschoten, E.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1995
- Volume
- 73
- Issue
- 02
- Pages
- 247-251
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2149564822
- Cited by
- 652
- References
- 1
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Nijmegen Modification of the Bethesda Assay for Factor VIII:C Inhibitors: Improved Specificity and Reliability. https://app.cochat.ai/papers/10.1055/s-0038-1653759
- The paper
- Verbruggen, B., Novakova, I., Wessels, H., Boezeman, J., van den Berg, M., & Mauser-Bunschoten, E. (1995). The Nijmegen Modification of the Bethesda Assay for Factor VIII:C Inhibitors: Improved Specificity and Reliability. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1653759
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