Maternal serum lipid, estradiol, and progesterone levels in pregnancy, and the impact of placental and hepatic pathologies
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OBJECTIVE: Lipids and steroid hormones are closely linked. While cholesterol is the substrate for (placental) steroid hormone synthesis, steroid hormones regulate hepatic lipid production. The aim of this study was to quantify circulating steroid hormones and lipid metabolites, and to characterize their interactions in normal and pathological pregnancies with a focus on hepatic and placental pathologies. METHODS: A total of 216 serum samples were analyzed. Group A consisted of 32 patients with uncomplicated pregnancies who were analyzed at three different time-points in pregnancy (from the first through the third trimester) and once post partum. Group B consisted of 36 patients (24th to 42nd week of gestation) with pregnancy pathologies (IUGR n = 10, preeclampsia n = 13, HELLP n = 6, intrahepatic cholestasis n = 7) and 31 controls with uncomplicated pregnancies. Steroid profiles including estradiol, progesterone, and dehydroepiandrosterone were measured by GC-MS and compared with lipid concentrations. RESULTS: In Group A, cholesterol and triglycerides correlated positively with estradiol (cholesterol ρ = 0.50, triglycerides ρ = 0.57) and progesterone (ρ = 0.49, ρ = 0.53) and negatively with dehydroepiandrosterone (ρ = - 0.47, ρ = - 0.38). Smoking during pregnancy affected estradiol concentrations, leading to lower levels in the third trimester compared to non-smoking patients (p < 0.05). In Group B, cholesterol levels were found to be lower in IUGR pregnancies and in patients with HELLP syndrome compared to controls (p < 0.05). Steroid hormone concentrations of estradiol (p < 0.05) and progesterone (p < 0.01) were lower in pregnancies with IUGR. DISCUSSION: Lipid and steroid levels were affected most in IUGR pregnancies, while only minor changes in concentrations were observed for other pregnancy-related disorders. Each of the analyzed entities displayed specific changes. However, since the changes were most obvious in pregnancies complicated by IUGR and only minor changes were observed in pregnancies where patients had impaired liver function, our data suggests that placental rather than maternal hepatic function strongly determines lipid and steroid levels in pregnancy.
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Maternal progesterone levels are reduced during IUGR, suggesting that placental steroidogenesis is affected.
“maternal progesterone levels are reported to be reduced during IUGR [62], suggesting that placental steroidogenesis is affected”
From Alternative (backdoor) androgen production and masculinization in the human fetus (2019) · cites this paper as [62]
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Walsh, B. W., Schiff, I., Rosner, B., Greenberg, L., Ravnikar, V., & Sacks, F. M. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110243251702 · Cited by 1,152 · see citing works
Estrogen suppresses transcription of lipoprotein lipase gene
Homma, H., Kurachi, H., Nishio, Y., Takeda, T., Yamamoto, T., Adachi, K., Morishige, K.-I., Ohmichi, M., Matsuzawa, Y., & Murata, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11404 · Cited by 209 · see citing works
Davis, R. A., Kern, F., Showalter, R., Sutherland, E. M., Sinensky, M. S., & Simon, F. R. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4130 · Cited by 198 · see citing works
Sattar, N. A., Greer, I. A., Louden, J., Lindsay, G., McConnell, M., Shepherd, J., & Packard, C. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4126 · Cited by 193 · see citing works
Abu‐Hayyeh, S., Papacleovoulou, G., Lövgren‐Sandblom, A., Tahir, M., Oduwole, O. O., Jamaludin, N. A., Ravat, S., Nikolova, V., Chambers, J., Selden, C., et al. (2012) · Hepatology · doi:10.1002/hep.26055 · Cited by 186 · see citing works
Dörr, H. G., HELLER, A., VERSMOLD, H. T., SIPPELL, W. G., HERRMANN, M., BIDLINGMAIER, F., & Knorr, D. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-5-863 · Cited by 147 · see citing works
Pre‐eclampsia is associated with, and preceded by, hypertriglyceridaemia: a meta‐analysis
Gallos, I. D., Sivakumar, K., Kilby, M. D., Coomarasamy, A., Thangaratinam, S., & Vatish, M. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12375 · Cited by 139 · see citing works
Sattar, N. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2483 · Cited by 127 · see citing works
Li, M., Reyes, H., Axelson, M., Palma, J., Hernández, I., Ribalta, J., & Sjövall, J. (1997) · Hepatology · doi:10.1002/hep.510260627 · Cited by 124 · see citing works
Triglyceride-Rich Lipoproteins Are Associated with Hypertension in Preeclampsia
Winkler, K., Wetzka, B., Hoffmann, M. M., Friedrich, I., Kinner, M., Baumstark, M. W., Zahradnik, H.-P., Wieland, H., & März, W. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021160 · Cited by 122 · see citing works
Rath, W., Faridi, A., & Dudenhausen, J. (2000) · Journal of Perinatal Medicine · doi:10.1515/jpm.2000.033 · Cited by 117 · see citing works
Self-citation3α-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period
Evans, S. E. G., Ross, L. E., Sellers, E. M., Purdy, R. H., & Romach, M. K. (2005) · Gynecological Endocrinology · doi:10.1080/09513590500361747 · Cited by 114 · see citing works
Steroid profiling in preeclamptic women: evidence for aromatase deficiency
Hertig, A., Lière, P., Chabbert‐Buffet, N., Fort, J., Pianos, A., Eychenne, B., Cambourg, A., Schumacher, M., Berkane, N. B., Lefèvre, G., et al. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.011 · Cited by 108 · see citing works
Baulieu, É.-É., & DRAY, F. (1963) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-23-12-1298 · Cited by 104 · see citing works
Winkler, K., Wetzka, B., Hoffmann, M. M., Friedrich, I., Kinner, M., Baumstark, M. W., Wieland, H., März, W., & Zahradnik, H. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7027 · Cited by 104 · see citing works
Lipid and Lipoprotein Concentrations in Pregnancies Complicated by Intrauterine Growth Restriction1
Sattar, N. A., Greer, I. A., Galloway, P. J., Packard, C. J., Shepherd, J., Kelly, T., & Mathers, A. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5419 · Cited by 98 · see citing works
The active management of intrahepatic cholestasis of pregnancy
Mays, J. K. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328337238d · Cited by 88 · see citing works
Plasma Lipid Profiles of Women With Intrahepatic Cholestasis of Pregnancy
Dann, A. T., Kenyon, A. P., Wierzbicki, A. S., Seed, P. T., Shennan, A. H., & Tribe, R. M. (2006) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000189096.94874.9c · Cited by 80 · see citing works
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain
Yawno, T., Hirst, J. J., Castillo-Meléndez, M., & Walker, D. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.009 · Cited by 79 · see citing works
Zhu, X., Bonet, B., & Knopp, R. H. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70462-9 · Cited by 69 · see citing works
Kelleher, M. A., Palliser, H. K., Walker, D. W., & Hirst, J. J. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0248 · Cited by 66 · see citing works
11β-Hydroxysteroid dehydrogenase type 2 in pregnancy and preeclampsia
Causevic, M., & Mohaupt, M. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.04.003 · Cited by 64 · see citing works
Self-citationPlasma lipids and desogestrel and ethinyl estradiol: a meta-analysis
Løbo, R. A., Skinner, J. B., Lippman, J. S., & Cirillo, S. J. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58321-6 · Cited by 59 · see citing works
Parker, C. R., Atkinson, M., Owen, J., & Andrews, W. W. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70428-3 · Cited by 58 · see citing works
Bartels, I., Hoppe‐Sievert, B., Bockel, B., Herold, S., & Caesar, J. (1993) · Prenatal Diagnosis · doi:10.1002/pd.1970130207 · Cited by 54 · see citing works
WALKER, B. W., Schiff, I., ROSNER, B. A., Greenberg, L., Ravnikar, V. A., & Sacks, F. M. (1992) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199203000-00024 · Cited by 48 · see citing works
Pecks, U., Caspers, R., Schießl, B., Bauerschlag, D., Piroth, D. M., Maass, N., & Rath, W. H. (2011) · Hypertension in Pregnancy · doi:10.3109/10641955.2010.544805 · Cited by 48 · see citing works
Self-citationLipid and Lipoprotein Concentrations in Pregnancies Complicated by Intrauterine Growth Restriction
Sattar, N. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.128 · Cited by 45 · see citing works
Schreuder, Y. J., Hutten, B. A., van Eijsden, M., Jansen, E. H. J. M., Vissers, M. N., Twickler, M., & Vrijkotte, T. G. M. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.282 · Cited by 42 · see citing works
Hentschke, M. R., Poli‐de‐Figueiredo, C. E., da Costa, B. E. P., Kurlak, L. O., Williams, P. J., & Mistry, H. D. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m036699 · Cited by 37 · see citing works
Peter, M., Dörr, H., & Sippell, W. G. (2008) · Hormone Research · doi:10.1159/000184209 · Cited by 34 · see citing works
Reimer, T., Rohrmann, H., Stubert, J., Pecks, U., Glocker, M. O., Richter, D.-U., & Gerber, B. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.733747 · Cited by 34 · see citing works
Self-citationRegulation of human placental trophoblast low-density lipoprotein uptake in vitro by estrogen.
Grimes, R. W., Pepe, G. J., & Albrecht, E. D. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675596 · Cited by 33 · see citing works
[Effects of micronized natural progesterone on the liver during the third trimester of pregnancy].
Bénifla, J., Dumont, M., Levardon, M., Foucher, E., Cadiot, G., Crenn‐Hébert, C., Heid, M., Lelaidier, C., Rosenbaum, A., Bernuau, J., et al. (1997) · PubMed · Cited by 30 · see citing works
Cigarette smoking during pregnancy lowers aromatase cytochrome P-450 in the human placenta
Kitawaki, J., Inoue, S., Tamura, T., Yamamoto, T., Honjo, H., Higashiyama, T., Osawa, Y., & Okada, H. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90163-q · Cited by 29 · see citing works
Kosicka, K., Siemiątkowska, A., Krzyścin, M., Bręborowicz, G. H., Resztak, M., Majchrzak‐Celińska, A., Chuchracki, M., & Główka, F. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144343 · Cited by 29 · see citing works
Wetzka, B., Winkler, K., Kinner, M., Friedrich, I., März, W., & Zahradnik, H.-P. (1999) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-994950 · Cited by 27 · see citing works
Pecks, U., Rath, W. H., Caspers, R., Sosnowsky, K., Ziems, B., Thiesen, H.-J., Maass, N., & Huppertz, B. (2013) · Placenta · doi:10.1016/j.placenta.2013.10.006 · Cited by 23 · see citing works
Self-citationRegulation of human placental trophoblast low-density lipoprotein uptake in vitro by estrogen
Grimes, R. W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.7.2675 · Cited by 23 · see citing works
Shanker, Y. G., Shetty, U. P., & Rao, A. J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006843812495 · Cited by 17 · see citing works
Al‐Azzawi, F., Wahab, M., Sami, S. A., Proudler, A. J., Thompson, J. R., & Stevenson, J. S. (2004) · Climacteric · doi:10.1080/13697130400001364 · Cited by 16 · see citing works
Stepan, H., Faber, R., & Walther, T. (1999) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1999.tb08153.x · Cited by 15 · see citing works
Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo
Vögeli, I., Jung, H. H., Dick, B., Erickson, S. K., Escher, R., Funder, J. W., Frey, F. J., & Escher, G. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0141 · Cited by 13 · see citing works
Self-citationPecks, U., Tillmann, D., Ernst, S., Maass, N., & Meinhold-Heerlein, I. M. (2012) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2012.01157.x · Cited by 7 · see citing works
Self-citationRabe, T., Kalbfleisch, H. H., Haun, A., & Runnebaum, B. (1983) · PubMed · Cited by 7 · see citing works
[Correlation of progesterone and apoprotein B in pregnancy].
Seiler, E., Ak, W., Schollberg, K., & Riehn, A. (1988) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Stepan H, Faber R, Walther T. Expression of low density lipoprotein re- ceptor messenger ribonucleic acid in placentas from pregnancies with intrauterine growth retardation. Br J Obstet Gynaecol 1999; 106: 1221-1222
Cited by
Sorted by citations
Alternative (backdoor) androgen production and masculinization in the human fetus
O’Shaughnessy, P. J., Antignac, J. P., Le Bizec, B., Morvan, M.-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.3000002 · Cited by 177 · see citing works
Androgens and the masculinization programming window: human–rodent differences
Sharpe, R. M. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200200 · Cited by 113 · see citing works
Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications
Hu, X., & Zhang, L. (2021) · Antioxidants · doi:10.3390/antiox10030405 · Cited by 88 · see citing works
The reduction in circulating levels of estrogen and progesterone in women with preeclampsia
Wan, J., Hu, Z., Zeng, K., Yin, Y., Zhao, M., Chen, M., & Chen, Q. (2017) · Pregnancy Hypertension · doi:10.1016/j.preghy.2017.12.003 · Cited by 81 · see citing works
Fleiss, B., Wong, F. Y., Brownfoot, F., Shearer, I. K., Baud, O., Walker, D. W., Gressèns, P., & Tolcos, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00188 · Cited by 73 · see citing works
Dunk, C., Kwan, M., Hazan, A. D., Walker, S. A., Wright, J. K., Harris, L. K., Jones, R. L., Keating, S. J., Kingdom, J. C., Whittle, W. L., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00160 · Cited by 63 · see citing works
Sex differences in Alzheimer’s disease: metabolic reprogramming and therapeutic intervention
Demetrius, L., Eckert, A., & Grimm, A. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.09.004 · Cited by 50 · see citing works
Estrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia
Shu, C., Han, S., Xu, P., Wang, Y., Cheng, T., & Hu, C. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s304316 · Cited by 47 · see citing works
MicroRNAs in Uteroplacental Vascular Dysfunction
Hu, X., & Zhang, L. (2019) · Cells · doi:10.3390/cells8111344 · Cited by 41 · see citing works
Sex-Specific Differences in Lipoprotein Production and Clearance
Conlon, D., Welty, F. K., Reyes‐Soffer, G., & Amengual, J. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318247 · Cited by 36 · see citing works
Hu, X., Song, R., & Zhang, L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9194269 · Cited by 35 · see citing works
Maternal nutrient metabolism in the liver during pregnancy
Fang, H., Li, Q., Wang, H., Ren, Y., Zhang, L., & Yang, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1295677 · Cited by 35 · see citing works
Gunaratne, M. D. S. K., Thorsteinsdottir, B., & Garovic, V. D. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01147-4 · Cited by 34 · see citing works
Pecks, U., Rath, W. H., Maass, N., Berger, B., Lueg, I., Farrokh, A., Farrokh, S., & Eckmann-Scholz, C. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0365-6 · Cited by 33 · see citing works
Self-citationContinued Investigation Into 17-OHPC
Amaral, L. M., Faulkner, J., ElFarra, J. T., Cornelius, D. C., Cunningham, M., Ibrahim, T., Vaka, V. R., McKenzie, J., & LaMarca, B. B. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09969 · Cited by 30 · see citing works
The Prenatal Hormone Milieu in Autism Spectrum Disorder
Worsham, W., Dalton, S., & Bilder, D. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.655438 · Cited by 29 · see citing works
The effect of estrogen in coronavirus disease 2019
Ma, Q., Hao, Z., & Wang, Y. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00332.2020 · Cited by 29 · see citing works
Hagenbeck, C., Hamza, A. S., Kehl, S., Maul, H., Lammert, F., Keitel, V., Hütten, M. C., & Pecks, U. (2021) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1386-3912 · Cited by 29 · see citing works
Self-citationHuman HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts
Zhu, H., Ren, Q., Yan, Z., Xu, S., Luo, J.-H., Wu, X., & Tang, C. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.014 · Cited by 27 · see citing works
Reijnders, D., Olson, K. N., Liu, C., Beckers, K. F., Ghosh, S., Redman, L. M., & Sones, J. L. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00334.2018 · Cited by 26 · see citing works
Dathan‐Stumpf, A., Vogel, M., Jank, A., Thiery, J., Kieß, W., & Stepan, H. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05342-2 · Cited by 24 · see citing works
Bizoń, A., Franik, G., Niepsuj, J., Czwojdzińska, M., Leśniewski, M., Nowak, A., Szynkaruk-Matusiak, M., Madej, P., & Piwowar, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173941 · Cited by 24 · see citing works
The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity
McBride, G. M., Wiese, M. D., Soo, J. Y., Darby, J. R. T., Berry, M. J., Varcoe, T. J., & Morrison, J. L. (2020) · Placenta · doi:10.1016/j.placenta.2020.07.012 · Cited by 16 · see citing works
Apheresis as emerging treatment option in severe early onset preeclampsia
Contini, C., Pütz, G., Pecks, U., & Winkler, K. (2019) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2019.08.028 · Cited by 15 · see citing works
Self-citationConcomitant intrauterine growth restriction alters the lipoprotein profile in preeclampsia
Contini, C., Winkler, B. S., Maass, N., Alkatout, İ., Winkler, K., & Pecks, U. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.12.006 · Cited by 15 · see citing works
Self-citationBai, M., Zeng, Q., Chen, Y., Chen, M., Li, P., Ma, Z., Sun, D., Zhou, H., Zheng, C., Zeng, S., et al. (2019) · Drug Metabolism and Disposition · doi:10.1124/dmd.119.086439 · Cited by 15 · see citing works
Pecks, U., Bornemann, V., Klein, A., Segger, L., Maass, N., Alkatout, İ., Eckmann-Scholz, C., Elessawy, M., & Lütjohann, D. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1117-1 · Cited by 15 · see citing works
Self-citationWölter, M., Okai, C. A., SMITH, D. S. H., Ruß, M., Rath, W. H., Pecks, U., Borchers, C. H., & Glocker, M. O. (2018) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201800017 · Cited by 12 · see citing works
Self-citationAlencar, A. K. N., Swan, K. F., Pridjian, G. C., Lindsey, S. H., & Bayer, C. L. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01112-7 · Cited by 9 · see citing works
Microglia alter sex-specific cerebellar myelination following placental hormone loss
Salzbank, J., Lacaille, H., Gaby, J., O’Reilly, J. J., Kissner, M. D., Vacher, C., & Penn, A. A. (2025) · Nature Communications · doi:10.1038/s41467-025-64814-z · Cited by 9 · see citing works
Syncytial nuclei accumulate at the villous surface in IUGR while proliferation is unchanged
Haeussner, E., Schmitz, C., Grynspan, D., von Koch, F. E., & Frank, H. (2017) · Placenta · doi:10.1016/j.placenta.2017.10.004 · Cited by 9 · see citing works
Hagenbeck, C., Pecks, U., Lammert, F., Hütten, M. C., Borgmeier, F., Fehm, T. N., Schleußner, E., Maul, H., Kehl, S., Hamza, A. S., et al. (2021) · Der Gynäkologe · doi:10.1007/s00129-021-04787-4 · Cited by 8 · see citing works
Self-citationVasků, M., Kleine-Eggebrecht, N., Rath, W. H., Mohaupt, M. G., Escher, G., & Pecks, U. (2017) · Pregnancy Hypertension · doi:10.1016/j.preghy.2017.11.012 · Cited by 8 · see citing works
Self-citationThe effect of maternal obesity and lipid profile on first-trimester serum progesterone levels
Bartha, I., Joumady, I., Cuerva, M. J., & Bartha, J. L. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.100959 · Cited by 8 · see citing works
Norda, S., Rausch, T. K., Orlikowsky, T. W., Hütten, M. C., Schulz, S., Göpel, W., & Pecks, U. (2017) · BioMed Research International · doi:10.1155/2017/2837027 · Cited by 7 · see citing works
Self-citationPu, Y., Du, Y., He, J., He, S., Chen, Y., Cao, A., & Dang, Y. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106591 · Cited by 6 · see citing works
Changes in Periodontal Parameters and C‐Reactive Protein After Pregnancy
Raga, L. G., Mínguez, I., Caffesse, R. G., & Llambés, F. (2016) · Journal of Periodontology · doi:10.1902/jop.2016.160093 · Cited by 6 · see citing works
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Raez‐Villanueva, S., Jamshed, L., Ratnayake, G., Cheng, L., Thomas, P. J., & Holloway, A. C. (2019) · Reproductive Toxicology · doi:10.1016/j.reprotox.2019.09.002 · Cited by 6 · see citing works
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Cui, M., Li, W., Ma, L., Ping, F., Liu, J., Wu, X., Mao, J., Wang, X., & Nie, M. (2017) · Oncotarget · doi:10.18632/oncotarget.18128 · Cited by 5 · see citing works
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Tadesse, E., Seifu, D., Menon, M., Tigeneh, W., Obsa, T., Neges, B., & Mehdi, M. (2021) · Research Square · doi:10.21203/rs.3.rs-966771/v1 · Cited by 2 · see citing works
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Wei, Y., Zhou, L., Zhao, X., Mao, L., Jia, Z., Mu, B., Shi, Z., & Hu, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-17933-y · Cited by 1 · see citing works
Saadat, N., Saeed, R., Pallas, B. D., Vyas, A. K., Auchus, R. J., & Padmanabhan, V. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112706 · Cited by 1 · see citing works
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Milinčić, M., & Gojnić, D. (2025) · Medicinski podmladak · doi:10.5937/mp76-51037
- Authors
- Pecks, U., Rath, W., Kleine-Eggebrecht, N., Maass, N., Voigt, F., Goecke, T., Mohaupt, M., & Escher, G.
- Affiliations
- University Hospital Schleswig-Holstein (DE)
- Universitätsklinikum Aachen (DE)
- University Hospital of Bern (CH)
- Corresponding author
- Pecks, U.
- Venue
- Geburtshilfe und Frauenheilkunde
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-07-20
- Volume
- 76
- Issue
- 07
- Pages
- 799-808
- ISSN
- 0016-5751 (ISSN-L)
- 1438-8804
- PMC
- PMC5001571
- OpenAlex
- W2496299465
- Cited by
- 53
- References
- 48
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2021: 12 · 2020: 2 · 2019: 11 · 2018: 2 · 2017: 6 · 2016: 2
- FWCI
- 9.04
- Type
- journal article
- Language
- de
- Open access
- bronze
- doi.org
- Locations
- Geburtshilfe und Frauenheilkunde (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- maternal serum lipids, estradiol, progesterone, dehydroepiandrosterone, cholesterol, triglycerides, fetal growth restriction, preeclampsia, HELLP syndrome, intrahepatic cholestasis of pregnancy, placental insufficiency, liver dysfunction, smoking during pregnancy, pregnancy complications, gestational hormones, hepatic lipid metabolism
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