The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial
Open accessAbstract
Abstract Introduction: Saffron (Crocus sativus L.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. Methods: 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. Results: 60 participants finished the study. Patients who received either saffron or citalopram showed significant improvement in scores of the Hamilton Rating Scale for Depression (P-value<0.001 in both groups) and Hamilton Rating Scale for Anxiety (P-value<0.001 in both groups). Comparison of score changes between the 2 trial arms showed no significant difference (P-value=0.984). Frequency of side effects was not significantly different between the 2 groups. Discussion: The present study indicates saffron as a potential efficacious and tolerable treatment for major depressive disorder with anxious distress.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Also, vilazodone -a serotonin reuptake inhibitor and 5-hydroxytryptamine 1A receptor partial antagonist -was more effective in 708 patients with anxious depression than in 155 patients with nonanxious depression, although the sample size of those with nonanxious depression was very small [59].”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [59]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643
Synergy and other interactions in phytomedicines
WILLIAMSON, E. (2001) · Phytomedicine · doi:10.1078/0944-7113-00060 · Cited by 1,027
Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., Biggs, M. M., Zisook, S., Leuchter, A., Howland, R., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111868 · Cited by 927
Lamers, F., van Oppen, P., Comijs, H. C., Smit, J. H., Spinhoven, P., van Balkom, A. J. L. M., Nolen, W. A., Zitman, F. G., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06176blu · Cited by 913
Rush, A. J. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.11.1905 · Cited by 879
New Vistas on Amygdala Networks in Conditioned Fear
Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841 · cited 1×
“Hyperactivity within the amygdala is described to be one of the most consistent abnormalities in the presence of anxiety and depression in one person, which is shown to be in response to hyperactivity in the locus coeruleus [11, 12].”
BackgroundSSRI Antidepressant Medications: Adverse Effects and Tolerability
Ferguson, J. M. (2001) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v03n0105 · Cited by 669 · cited 2×
“Dur - ing SSRI therapy, the most troubling adverse effects are sexual dys - function, gastrointestinal disturbances, weight gain, anxiety, agitation, and sleep disturbances [18–20].”
Research works printed but not linked: 1
- Lépine J-P, Gastpar M, Mendlewicz J et al. Depression in the communi- ty: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol 1997; 12: 19-29
Cited by
Sorted by citations
Saffron (Crocus sativus L.), the king of spices: An overview
Cardone, L., Castronuovo, D., Perniola, M., Cicco, N., & Candido, V. (2020) · Scientia Horticulturae · doi:10.1016/j.scienta.2020.109560 · Cited by 280
Saffron: An Old Medicinal Plant and a Potential Novel Functional Food
Bagur, M. J., Salinas, G. L. A., Jiménez‐Monreal, A. M., Chaouqi, S., Llorens, S., Martínez‐Tomé, M., & Alonso, G. L. (2017) · Molecules · doi:10.3390/molecules23010030 · Cited by 235
Cerdá-Bernad, D., Valero‐Cases, E., Pastor, J.-J., & Fernández, M. J. F. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1864279 · Cited by 206
Shafiee, M., Arekhi, S., Omranzadeh, A., & Sahebkar, A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.020 · Cited by 185
Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower
Moratalla‐López, N., Bagur, M. J., Lorenzo, C., Martínez‐Navarro, M. E., Salinas, M. R., & Alonso, G. L. (2019) · Molecules · doi:10.3390/molecules24152827 · Cited by 152
Metadata
- Authors
- Ghajar, A., Neishabouri, S., Velayati, N., Jahangard, L., Matinnia, N., Haghighi, M., Ghaleiha, A., Afarideh, M., Salimi, S., Meysamie, A., & Akhondzadeh, S.
- Affiliations
- Roozbeh Hospital (IR)
- Hamedan University of Medical Sciences (IR)
- Baharloo Hospital (IR)
- Tehran University of Medical Sciences (IR)
- ORCID
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-10-04
- Volume
- 50
- Issue
- 04
- Pages
- 152-160
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2528662465
- Cited by
- 110
- References
- 71
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 28 · 2020: 14 · 2019: 7 · 2018: 9 · 2017: 6
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Saffron Plant Research Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- saffron, citalopram, major depressive disorder, anxious distress, antidepressant effects, anxiolytic effects, herbal medicine
- MeSH terms
- Adolescent, Adult, Aged, Antidepressive Agents, Anxiety, Depressive Disorder, Major, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Phytotherapy, Middle Aged, Plant Extracts, Citalopram, Treatment Outcome, Crocus, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
