Disorders of Frontal Lobe Functioning
Abstract
The neurology of frontal lobe disorders can be summarized in descriptions of behavioral problems (apathy, etc.), of cognitive impairments (poor planning, etc.), and of motor deficits (grasp reflex, etc.). Reviews of this sort do not indicate, however, any regional specificity to the deficit profiles or identify any of the component processes of the complex deficits-what exactly is "poor planning"? In this review we present specific steps that assist in overcoming the limitations: (1) identify weaknesses in current understanding, (2) operationally define the processes to be analyzed, (3) review some methodologies that allow parsing of discreet processes into specific frontal regions, (4) review the unique advantages and disadvantages of the various neurological disorders that provide us with subjects for study, and (5) propose approaches to advance further a useful clinical neurology of frontal lobe disorders as well as a more finely grained scientific description of core frontal processes.
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Executive function processes are inter-related and can be conceptualized as an integrated supervisory or control system.
“while executive function may comprise several distinct processes, they are inter-related and could still be conceptualized, and referred to, as an integrated supervisory or control system”
From Assessing Executive Function in Preschoolers (2012) · cites this paper as Alexander & Stuss, 2000
Damage at any level of prefrontal networks could potentially result in impairments commonly associated with executive dysfunction.
“damage at any level of these prefrontal networks could potentially result in impairments commonly associated with executive dysfunction”
From Assessing Executive Function in Preschoolers (2012) · cites this paper as Alexander & Stuss, 2000
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Assessment and Development of Executive Function (EF) During Childhood
Anderson, P. (2002) · Child Neuropsychology · doi:10.1076/chin.8.2.71.8724 · Cited by 2,218 · see citing works
“As a consequence of this complex neural network, executive dysfunction is not always associated with prefrontal pathology directly, but may be related to network disconnections such as white matter damage or impairment to other brain regions (Alexander & Stuss, 2000; Eslinger & Grattan, 1993).”
BackgroundInfluentialAssessing Executive Function in Preschoolers
Anderson, P. J., & Reidy, N. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9220-3 · Cited by 293 · see citing works
Remembering and Knowing in Patients with Frontal Lobe Injuries
WHEELER, M., & STUSS, D. (2003) · Cortex · doi:10.1016/s0010-9452(08)70866-9 · Cited by 133 · see citing works
Self-citationSmidts, D. P., Jacobs, R., & Anderson, V. (2004) · Developmental Neuropsychology · doi:10.1207/s15326942dn2601_2 · Cited by 111 · see citing works
The factor structure of executive function in childhood and adolescence.
Laureys, F., De Waelle, S., Barendse, M. T., Lenoir, M., & Deconinck, F. J. A. (2022) · Intelligence · doi:10.1016/j.intell.2021.101600 · Cited by 92 · see citing works
- Authors
- Alexander, M. P., & Stuss, D. T.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Seminars in Neurology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2000
- Volume
- 20
- Issue
- 04
- Pages
- 427-438
- ISSN
- 0271-8235 (ISSN-L)
- 1098-9021
- OpenAlex
- W2055406377
- Cited by
- 126
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 5 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- frontal lobe disorders, frontal lobe dysfunction, apathy, cognitive impairment, grasp reflex, motor impairment, behavioral problems
- MeSH terms
- Aphasia, Attention Deficit Disorder with Hyperactivity, Behavioral Symptoms, Brain Injuries, Cognition Disorders, Consciousness Disorders, Dementia, Frontal Lobe, Humans, Memory Disorders, Movement Disorders, Neoplasms, Stroke
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