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Terpenoids and Flavonoids from Artemisia Species
Abstract
A phytochemical reinvestigation of the aerial parts of Artemisia sieversiana gave a new guaianolide and two known flavones (chrysosplenetin and 5-hydroxy-3',4',6,7-tetramethoxyflavone). Antifungal fractions derived from the chloroform extract of A. annua afforded two cadinane derivatives (arteannuin B and artemisinin), oleanolic acid, beta-sitosterol, stigmasterol, and the four flavones artemetin, bonanzin, eupalitin and chrysosplenetin. Their structures were elucidated by spectral methods. All isolates from the two species were tested in vitro for antifungal activity. Arteannuin B, a main sesquiterpenoid in A. annua, showed antifungal activity against one human (Candida albicans, MIC: 100 micrograms/ml) and four plant pathogenic fungi (Gaeumannomyces graminis var. tritici, Rhizoctonia cerealis, Gerlachia nivalis and Verticillium dahliae, MICs: 150, 100, 150 and 100 micrograms/ml, respectively) whereas others showed no antifungal activity. The MIC value of ketoconazole to C. albicans was 1.0 microgram/ml, and those of triadimefon to G. graminis var. tritici and R. cerealis 150 and 100 micrograms/ml.
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“The most abundant sterols from A. annua are stigmasterol (570) and sitosterol (568) [96], which are ubiquitous components of plant cell membranes.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [96]
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The Antiviral Activities of Artemisinin and Artesunate
Efferth, T., Romero, M. R., Wolf, D. G., Stamminger, T., Marin, J. J. G., & Marschall, M. (2008) · Clinical Infectious Diseases · doi:10.1086/591195 · Cited by 503
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15
Li, J. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i3.493 · Cited by 215
Terpenoids from the seeds of Artemisia annua
Brown, G. D., Liang, G.-Y., & Sy, L.-K. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00294-2 · Cited by 153
Kim, K., Lee, J., Park, H., et al. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.020 · Cited by 146
Metadata
- Authors
- Tang, H., Hu, J., Yang, L., & Tan, R.
- Affiliations
- Nanjing University (CN)
- Lanzhou University (CN)
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2000-12-31
- Volume
- 66
- Issue
- 04
- Pages
- 391-393
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2044390909
- Cited by
- 104
- References
- 0
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Keywords
- Artemisia sieversiana, Artemisia annua, guaianolides, flavones, arteannuin B, artemisinin, cadinane sesquiterpenoids, antifungal activity, Candida albicans, Gaeumannomyces graminis var. tritici, Rhizoctonia cerealis, Verticillium dahliae, phytochemistry
- MeSH terms
- Antifungal Agents, Flavonoids, Microbial Sensitivity Tests, Plants, Medicinal, Terpenes, Artemisia
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