The Antiviral Activities of Artemisinin and Artesunate

Arzneimittelforschung

Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works

Antiviral Actions of Interferons

Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743 · see citing works

Viral Hepatitis and Liver Disease

Vyas, G. N., Dienstag, J. L., & Hoofnagle, J. H. (1985) · Medical Entomology and Zoology · Cited by 1,867 · see citing works

Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.

(2005) · The Lancet · doi:10.1016/s0140-6736(05)67176-0 · Cited by 1,050 · see citing works

Artemisinin: mechanisms of action, resistance and toxicity

Meshnick, S. R. (2002) · International Journal for Parasitology · doi:10.1016/s0020-7519(02)00194-7 · Cited by 732 · see citing works

The anti-malarial artesunate is also active against cancer

Efferth, T., Dunstan, H. M., Sauerbrey, A., Miyachi, H., & Chitambar, C. R. (2001) · International Journal of Oncology · doi:10.3892/ijo.18.4.767 · Cited by 567 · see citing works

Artesunate combinations for treatment of malaria: meta-analysis

Adjuik, M., Babiker, A. G., Garner, P., Olliaro, P., Taylor, W. R. J., & White, N. J. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15162-8 · Cited by 537 · see citing works

Molecular Modes of Action of Artesunate in Tumor Cell Lines

Efferth, T., Sauerbrey, A., Olbrich, A., Gebhart, E., Rauch, P., Weber, H. O., Hengstler, J. G., Halatsch, M., Volm, M., Tew, K. D., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.382 · Cited by 430 · see citing works

Human Cytomegalovirus with IE-2 (UL122) Deleted Fails To Express Early Lytic Genes

Marchini, A., Liu, H., & Zhu, H. (2001) · Journal of Virology · doi:10.1128/jvi.75.4.1870-1878.2001 · Cited by 340 · see citing works

Mechanism of action of ribavirin in the combination treatment of chronic HCV infection

Lau, J. Y. N., Tam, R. C., Liang, J. T., & Hong, Z. (2002) · Hepatology · doi:10.1053/jhep.2002.32672 · Cited by 337 · see citing works

Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF‐κB

Bork, P. M., Schmitz, M. L., Kuhnt, M., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01502-5 · Cited by 328 · see citing works

Novel mechanism for reverse transcription in hepatitis B viruses

Wang, G. H., & Seeger, C. (1993) · Journal of Virology · doi:10.1128/jvi.67.11.6507-6512.1993 · Cited by 294 · see citing works

Fatal Neurotoxicity of Arteether and Artemether

Brewer, T. G., Grate, S. J., Peggins, J. O., Weina, P. J., Petras, J. M., LEVINE, B. S., Heiffer, M. H., & Schuster, B. G. (1994) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1994.51.251 · Cited by 270 · see citing works

Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to Bedside

Efferth, T. (2007) · Planta Medica · doi:10.1055/s-2007-967138 · Cited by 269 · see citing works

Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells

Efferth, T. (2006) · Current Drug Targets · doi:10.2174/138945006776359412 · Cited by 263 · see citing works

A Trial of Artemether or Quinine in Children with Cerebral Malaria

van Hensbroek, M. B., Onyiorah, E., Jaffar, S. S., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607113350201 · Cited by 258 · see citing works

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

Yurochko, A. D., Kowalik, T. F., Huong, S.-M., et al. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5391-5400.1995 · Cited by 256 · see citing works

Neurotoxicity in animals due to arteether and artemether

Brewer, T. G., Peggins, J. O., Grate, S. J., Petras, J. M., LEVINE, B. S., Weina, P. J., Swearengen, J. R., Heiffer, M. H., & Schuster, B. G. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90469-3 · Cited by 253 · see citing works

Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB

Siedle, B., García‐Piñeres, A., Murillo, R., Schulte‐Mönting, J., Castro, V., Rüngeler, P., Klaas, C. A., Costa, F. B. D., Kisiel, W., & Merfort, I. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049937r · Cited by 248 · see citing works

Human Cytomegalovirus Up-Regulates the Phosphatidylinositol 3-Kinase (PI3-K) Pathway: Inhibition of PI3-K Activity Inhibits Viral Replication and Virus-Induced Signaling

Johnson, R. A., Wang, X., Ma, X.-C., Huong, S., & Huang, E.-S. (2001) · Journal of Virology · doi:10.1128/jvi.75.13.6022-6032.2001 · Cited by 246 · see citing works

Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an “in vitro” replicative system

Romero, M. R., Efferth, T., Serrano, M. A., Castaño, B., Macı́as, R. I. R., Briz, Ó., & Marı́n, J. J. G. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.07.005 · Cited by 233 · see citing works

Identification of human cytochrome P 450 s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

Li, X., Bj�rkman, A., Andersson, T. B., et al. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-003-0636-9 · Cited by 232 · see citing works

Artemisinins for schistosomiasis and beyond.

Utzinger, J., Xiao, S.-H., Tanner, M., & Keiser, J. (2007) · PubMed · Cited by 232 · see citing works

Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor

Burk, O., Arnold, K. A., Nussler, A. K., Schaeffeler, E., Ефимова, Е. А., Avery, B. A., Avery, M. A., Fromm, M. F., & Eichelbaum, M. F. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.009019 · Cited by 225 · see citing works

WHO, the Global Fund, and medical malpractice in malaria treatment

Attaran, A., Barnes, K. I., Curtis, C. F., D’Alessandro, U., Fanello, C. A., Galinski, M. R., Kokwaro, G. O., Looareesuwan, S., Makanga, M. M., Mutabingwa, T. K., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15330-5 · Cited by 216 · see citing works

EASL INTERNATIONAL CONSENSUS CONFERENCE ON HEPATITIS B

Jury, E. (2003) · Cited by 214 · see citing works

Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

Svensson, & Ashton (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00044.x · Cited by 207 · see citing works

Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses

Efferth, T., Marschall, M., Wang, X., et al. (2001) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0300-8 · Cited by 183 · see citing works

Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy

Efferth, T. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2005.04.003 · Cited by 169 · see citing works

Artesunate as a Potent Antiviral Agent in a Patient with Late Drug‐Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation

Shapira, M. Y., Resnick, I. B., Chou, S., Neumann, A. U., Lurain, N. S., Stamminger, T., Caplan, O., Saleh, N., Efferth, T., Marschall, M., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587106 · Cited by 157 · see citing works

Artemisinin‐based combination therapies for uncomplicated malaria

Davis, T. M. E., Karunajeewa, H., & Ilett, K. F. (2005) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2005.tb06650.x · Cited by 155 · see citing works

Artesunate

Barradell, L. B., & Fitton, A. (1995) · Drugs · doi:10.2165/00003495-199550040-00009 · Cited by 149 · see citing works

The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo

Kaptein, S. J. F., Efferth, T., Leis, M., Rechter, S., Auerochs, S., Kalmer, M., Bruggeman, C. A., Vink, C., Stamminger, T., & Marschall, M. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.10.003 · Cited by 148 · see citing works

Highly Antimalaria‐Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity

Haynes, R. K., Ho, W., Chan, H., Fugmann, B., Stetter, J., Croft, S. L., Vivas, L., Peters, W., & Robinson, B. L. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200352343 · Cited by 148 · see citing works

Recombinant Green Fluorescent Protein-Expressing Human Cytomegalovirus as a Tool for Screening Antiviral Agents

Marschall, M., Freitag, M., Weiler, S., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.6.1588-1597.2000 · Cited by 144 · see citing works

Safety of artemisinin and its derivatives. A review of published and unpublished clinical trials.

Ribeiro, I. R., & Olliaro, P. (1998) · PubMed · Cited by 144 · see citing works

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

Yurochko, A. D., Mayo, M. W., Poma, E., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4638-4648.1997 · Cited by 143 · see citing works

Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives

White, N. J. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90471-5 · Cited by 140 · see citing works

Pharmacokinetic Interactions of Antimalarial Agents

Giao, P. T., & de Vries, P. J. (2001) · Clinical Pharmacokinetics · doi:10.2165/00003088-200140050-00003 · Cited by 137 · see citing works

Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents

Buckwold, V. E., Beer, B., & Donis, R. O. (2003) · Antiviral Research · doi:10.1016/s0166-3542(03)00174-8 · Cited by 135 · see citing works

Mechanisms of Action of Ribavirin in Antiviral Therapies

Tam, R. C., Lau, J. Y. N., & Hong, Z. (2001) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020101200501 · Cited by 130 · see citing works

A pharmacokinetic and pharmacodynamic study of intravenous vs oral artesunate in uncomplicated falciparum malaria

Batty, K. T., Thư, L. T. A., Davis, T. M. E., et al. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00655.x · Cited by 129 · see citing works

A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria

The Artemether-Quinine Meta-analysis Study Group† (2001) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(01)90104-x · Cited by 126 · see citing works

Selective high-performance liquid chromatographic determination of artesunate and α- and β-dihydroartemisinin in patients with falciparum malaria

Batty, K. T., Davis, T. M. E., Thư, L. T. A., et al. (1996) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00428-9 · Cited by 123 · see citing works

Antiviral Effect of Artemisinin from Artemisia annua against a Model Member of the Flaviviridae Family, the Bovine Viral Diarrhoea Virus (BVDV)

Romero, M. R., Serrano, M. A., Vallejo, M., Efferth, T., Alvarez, M., & Marı́n, J. J. G. (2006) · Planta Medica · doi:10.1055/s-2006-947198 · Cited by 122 · see citing works

Alkylation of proteins by artemisinin

Yang, Y., Little, B., & Meshnick, S. R. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90287-9 · Cited by 121 · see citing works

Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

Ghazal, P., Luboń, H., Fleckenstein, B., & Hennighausen, L. G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3658 · Cited by 118 · see citing works

Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus

Fillebeen, C., Rivas, A., Bisaillon, M., Ponka, P., Muckenthaler, M. U., Hentze, M. W., Koromilas, A. E., & Pantopoulos, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412687200 · Cited by 112 · see citing works

Detection of apoptosis in KG-1a leukemic cells treated with investigational drugs.

Efferth, T., Rüċker, G., Falkenberg, M. B., Manns, D., Olbrich, A., Fabry, U., & Osieka, R. (1996) · PubMed · Cited by 105 · see citing works

Terpenoids and Flavonoids from <i>Artemisia</i> Species

Tang, H., Hu, J., Yang, L., & Tan, R. (2000) · Planta Medica · doi:10.1055/s-2000-8538 · Cited by 104 · see citing works

Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria

McGready, R., Stepniewska, K., Ward, S. A., Cho, T., Gilveray, G., Looareesuwan, S., White, N. J., & Nosten, F. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-006-0118-y · Cited by 101 · see citing works

Artemisinin Neurotoxicity: Neuropathology in Rats and Mechanistic Studies in Vitro

Kamchonwongpaisan, S., McKeever, P. E., Hossler, P. A., Ziffer, H., & Meshnick, S. R. (1997) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1997.56.7 · Cited by 98 · see citing works

Initiation and termination of duck hepatitis B virus DNA synthesis during virus maturation

Lien, J. M., Petcu, D. J., Aldrich, C. E., et al. (1987) · Journal of Virology · doi:10.1128/jvi.61.12.3832-3840.1987 · Cited by 97 · see citing works

A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first‐pass hepatic extraction

Gordi, T., Xie, R., Hướng, N. V., et al. (2005) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2004.02321.x · Cited by 97 · see citing works

Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high‐throughput inhibition screening of terpenoids

He, F., Bi, H., Xie, Z., et al. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2881 · Cited by 94 · see citing works

Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 6. The Development of Predictive In Vitro Potency Models Using CoMFA and HQSAR Methodologies

Avery, M. A., Alvim‐Gaston, M., Rodrigues, C. R., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0100234 · Cited by 85 · see citing works

Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects

Asimus, S., Elsherbiny, D. A., Hai, T. N., Jansson, B., Hướng, N. V., Petzold, M., Simonsson, U. S. H., & Ashton, M. (2007) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00471.x · Cited by 81 · see citing works

Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin

Paeshuyse, J., Coelmont, L., Vliegen, I., hemel, J. V., Vandenkerckhove, J., Peys, E., Sas, B., Clercq, E. D., & Neyts, J. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.014 · Cited by 76 · see citing works

Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria.

Teja‐Isavadharm, P., Watt, G., Eamsila, C., Jongsakul, K., Li, Q., Keeratithakul, G., Sirisopana, N., Luesutthiviboon, L., Brewer, T. G., & Kyle, D. E. (2001) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.65.717 · Cited by 76 · see citing works

Oral bioavailability of dihydroartemisinin in Vietnamese volunteers and in patients with falciparum malaria

Bình, T. Q., Ilett, K. F., Batty, K. T., Davis, T. M. E., Hung, N. C., Powell, S. M., Thư, L. T. A., Thien, H. V., Phuöng, H. L., & Phuong, V. D. B. (2001) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2001.01395.x · Cited by 75 · see citing works

Arteether: Risks of Two-Week Administration in Macaca mulatta

Petras, J. M., Kyle, D. E., Gettayacamin, M., et al. (1997) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1997.56.390 · Cited by 73 · see citing works

Neurotoxicity and efficacy of arteether related to its exposure times and exposure levels in rodents.

Li, Q., Mog, S. R., Z., Y., et al. (2002) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2002.66.516 · Cited by 67 · see citing works

The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu.

Tu, Y. (1999) · PubMed · doi:10.3760/cma.j.issn.0366-6999.1999.11.105 · Cited by 67 · see citing works

The Pharmacokinetics of a Single Dose of Artemisinin in Healthy Vietnamese Subjects

Duc, D. D., de Vries, P. J., Khanh, N. X., Binh, L. N., Kager, P. A., & van Boxtel, C. J. (1994) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1994.51.785 · Cited by 66 · see citing works

Dose-Dependent Brainstem Neuropathology Following Repeated Arteether Administration in Rats

Genovese, R. F., Newman, D. B., Li, Q., et al. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00339-0 · Cited by 66 · see citing works

Development of QSAR Models To Predict and Interpret the Biological Activity of Artemisinin Analogues

Guha, R., & Jurs, P. C. (2004) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci0499469 · Cited by 62 · see citing works

Effects of Interferon, Ribavirin, and Iminosugar Derivatives on Cells Persistently Infected with Noncytopathic Bovine Viral Diarrhea Virus

Durantel, D., Carrouée‐Durantel, S., Branza‐Nichita, N., Dwek, R. A., & Zitzmann, N. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.2.497-504.2004 · Cited by 61 · see citing works

A pharmacokinetic and pharmacodynamic study of artesunate for vivax malaria.

Batty, K. T., Le, A. T., Ilett, K. F., et al. (1998) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1998.59.823 · Cited by 60 · see citing works

Delayed clearance of Plasmodium falciparum in patients with human immunodeficiency virus co-infection treated with artemisinin.

Birku, Y., Mekonnen, E., Björkman, A., & Wolday, D. (2002) · PubMed · Cited by 58 · see citing works

Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts

Naesens, L. M. J., Bonnafous, P., Agut, H., & Clercq, E. D. (2006) · Journal of Clinical Virology · doi:10.1016/s1386-6532(06)70015-4 · Cited by 57 · see citing works

Hepatitis B Virus Mutants and Fulminant Hepatitis B: Fitness Plus Phenotype

Bartholomeusz, A., & Locarnini, S. (2001) · Hepatology · doi:10.1053/jhep.2001.26764 · Cited by 55 · see citing works

Toxic brainstem encephalopathy after artemisinin treatment for breast cancer

Panossian, L. A., Garga, N. I., & Pelletier, D. (2005) · Annals of Neurology · doi:10.1002/ana.20620 · Cited by 54 · see citing works

High-performance liquid chromatographic determination of artemisinine (Qinghaosu) in human plasma and saliva

Zhao, S. (1987) · The Analyst · doi:10.1039/an9871200661 · Cited by 52 · see citing works

Arteether-induced brain injury in Macaca mulatta . I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei

Petras, J. M., Young, G. D., Bauman, R. A., et al. (2000) · Anatomy and Embryology · doi:10.1007/s004290050326 · Cited by 49 · see citing works

Natural History of Hepatitis B and C Virus Infections

Iino, S. (2002) · Oncology · doi:10.1159/000048271 · Cited by 49 · see citing works

Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans

Bapiro, T. E., Sayi, J., Hasler, J. A., Jande, M. B., Rimoy, G., Masselle, A., & Masimirembwa, C. M. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0037-3 · Cited by 47 · see citing works

Are currently deployed artemisinins neurotoxic?

Toovey, S. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.06.001 · Cited by 47 · see citing works

Behavioral and Neural Toxicity of Arteether in Rats

Genovese, R. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00019-7 · Cited by 45 · see citing works

Cytochrome P 450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells

Bapiro, T. E., Andersson, T. B., Otter, C. A., et al. (2002) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-002-0512-z · Cited by 42 · see citing works

In vivoand mechanistic evidence of nuclear receptor CAR induction by artemisinin

Simonsson, U. S. H., Lindell, M., Raffalli‐Mathieu, F., et al. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01700.x · Cited by 40 · see citing works

NF-κB A Potential Therapeutic Target for Inhibition of Human Cytomegalovirus (Re)activation?

Prösch, S., Wuttke, R., Krüger, D. H., et al. (2002) · Biological Chemistry · doi:10.1515/bc.2002.181 · Cited by 36 · see citing works

RICK Activates a NF-κB-dependent Anti-human Cytomegalovirus Response

Eickhoff, J., Hanke, M., Stein-Gerlach, M., Kiang, T. P., Herzberger, K., Habenberger, P., Müller, S., Klebl, B., Marschall, M., Stamminger, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312893200 · Cited by 35 · see citing works

A modified technique for the detection of hepatitis B virus-specific DNA polymerase

Fang, C. T., Nath, N., Pielech, M., et al. (1981) · Journal of Virological Methods · doi:10.1016/0166-0934(81)90058-6 · Cited by 32 · see citing works

Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19

Mihara, K., Svensson, U. S. H., Tybring, G., et al. (1999) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1999.tb00379.x · Cited by 32 · see citing works

A study on antimalarial artemisinin derivatives using MEP maps and multivariate QSAR

Cardoso, F. J. B., de Figueiredo, A. F., Lobato, M. D. S., et al. (2007) · Journal of Molecular Modeling · doi:10.1007/s00894-007-0249-9 · Cited by 29 · see citing works

Characterisation of the human liver in vitro metabolic pattern of artemisinin and auto‐induction in the rat by use of nonlinear mixed effects modelling

Svensson, U. S. H., Mäki‐Jouppila, M., Hoffmann, K., et al. (2003) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.342 · Cited by 25 · see citing works

The immunologic and antiviral effect of qinghaosu.

Qian, R. S., Li, Z. L., Yu, J., et al. (1982) · PubMed · Cited by 23 · see citing works

Antiviral Activity and Intracellular Metabolism of Bis(tButylSATE) Phosphotriester of β-L-2′,3'Dideoxyadenosine, a Potent Inhibitor of HIV and HBV Replication

Placidi, L., Faraj, A., Loi, A., et al. (2001) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020101200203 · Cited by 14 · see citing works

Effects of Artemisinin, Artemether, Arteether on the Pharmacokinetics of Carbamazepine

Sukhija, M., Medhi, B., & Pandhi, P. (2005) · Pharmacology · doi:10.1159/000090434 · Cited by 13 · see citing works

Pathogenesis and treatment of hepatitis C virus-related liver diseases.

Tanikawa, K. (2004) · PubMed · Cited by 10 · see citing works

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

Efferth, T. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.009 · Cited by 632 · see citing works

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in <i>Artemisia annua</i> plants

Maes, L., Van Nieuwerburgh, F. C. W., Zhang, Y., Reed, D. W., Pollier, J., Vande Casteele, S. R. F., Inzé, D., Covello, P. S., Deforce, D. L. D., & Goossens, A. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2010.03466.x · Cited by 240 · see citing works

Sesquiterpene Lactones from<i>Artemisia</i>Genus: Biological Activities and Methods of Analysis

Ivanescu, B., Miron, A., & Corciova, A. (2015) · Journal of Analytical Methods in Chemistry · doi:10.1155/2015/247685 · Cited by 201 · see citing works

Beyond malaria: The inhibition of viruses by artemisinin-type compounds

Efferth, T. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.01.001 · Cited by 157 · see citing works

Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches

Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works

Potential Ecological Roles of Artemisinin Produced by Artemisia annua L.

Knudsmark Jessing, K., Duke, S. O., & Cedergreeen, N. (2014) · Journal of Chemical Ecology · doi:10.1007/s10886-014-0384-6 · Cited by 69 · see citing works

In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans

Mesa, L. E., Vasquez, D., Lutgen, P., Vélez, I. D., Restrepo, A. M., Ortiz, I., & Robledo, S. M. (2017) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0457-2016 · Cited by 39 · see citing works

Overexpression of the gibberellin 20-oxidase gene from Torenia fournieri resulted in modified trichome formation and terpenoid metabolities of Artemisia annua L.

Inthima, P., Nakano, M., Otani, M., Niki, T., Nishijima, T., Koshioka, M., & Supaibulwatana, K. (2017) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1171-1 · Cited by 26 · see citing works

Adaptation and agronomic performance of Artemisia annua L. under lowland humid tropical conditions

Brisibe, E. A., Udensi, O., Chukwurah, P. N., de Magalhäes, P. M., Figueira, G. M., & Ferreira, J. F. S. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.02.018 · Cited by 25 · see citing works

Is Artemisinin the Only Antiplasmodial Compound in the Artemisia annua Tea Infusion? An in Vitro Study

Mouton, J., Jansen, O., Frédérich, M., & van der Kooy, F. (2013) · Planta Medica · doi:10.1055/s-0032-1328324 · Cited by 20 · see citing works

Artemisia annua glandular secretory trichomes： the biofactory of antimalarial agent artemisinin

Ling, Xiao, X., Hexin, et al. (2016) · 中国科学通报：英文版

A review of various efforts to increase artemisinin and other antimalarial compounds in Artemisia Annua L plant

Aidah, N., Bazira, J., Tolo, C. U., & Engeu, P. O. (2018) · Cogent Biology · doi:10.1080/23312025.2018.1513312 · Cited by 16 · see citing works

Self-immobilized aggreage culture of Artemisia annua L. for imroved artemisinin

Hu, F., Chen, C.-L., & Guanlin, W. (2003) · Zhiwu yanjiu

Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.

Liu, B., Wang, H., Du, Z., Li, G., & Ye, H. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0967-9 · Cited by 82 · see citing works