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Cited by 27Hormonal and reproductive studiesLipoproteins and Cardiovascular HealthMenopause: Health Impacts and Treatments

Impact on Lipoprotein Profile after Long-Term Testosterone Replacement in Hypogonadal Men

Berg, G., Schreier, L., Geloso, G., Otero, P., Nagelberg, A., Levalle, O.·2002·Hormone and Metabolic Research
DOI 10.1055/s-2002-20521
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Abstract

Testosterone serum levels may influence the lipoprotein metabolism and possibly atherogenic risk. Our aim was to investigate the effects of long-term testosterone supplementation in hypogonadal men on multiple lipoprotein markers. 18 Hypogonadal men were studied before and after 3, 6, and 18 (n = 7) months of treatment with testosterone enanthate. During treatment, serum testosterone and estradiol increased, reaching normal levels (p < 0.0001 and 0.003, respectively). This was associated with a decrease in HDL cholesterol (from 1.40 +/- 0.10 mmol/l to 1.22 +/- 0.08 mmol/l, p < 0.001) after six months at the expense of HDL2 cholesterol (p < 0.01), as well as apoprotein A1 (from 139 +/- 3.4 mg/dl to 126 +/- 3.0 mg/dl, p < 0.005). Hepatic lipase activity increased (p < 0.05) and correlated positively with testosterone (r = 0.56, p < 0.02) and negatively with HDL cholesterol (r = - 0.58, p < 0.02). Total and LDL cholesterol, triglycerides, and apoprotein B did not increase. Among the seven patients who completed 18 months of treatment, triglycerides, total cholesterol, LDL and HDL cholesterol, as well as total cholesterol/HDL cholesterol ratio values did not differ from baseline while apoprotein A1 (p < 0.03) and HDL cholesterol (p < 0.015) remained decreased and hepatic lipase unchanged. Restoration of testosterone levels in hypogonadal men in this study did not reveal unfavorable changes based on total cholesterol/HDL cholesterol and LDL cholesterol/apoprotein B ratios, which are both atherogenic risk markers. Whether the changes in light of lipoprotein metabolism will adversely influence cardiovascular risk over time remains to be determined.

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Authors
Berg, G., Schreier, L., Geloso, G., Otero, P., Nagelberg, A., & Levalle, O.
Affiliations
  • Universidad de Buenos Aires (AR)
  • El Hospital General de Agudos Carlos G. Durand (AR)
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2002-02
Volume
34
Issue
2
Pages
87-92
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2002-20521
OpenAlex
W2087050576
Cited by
27
References
0
Citations by year
2023: 1 · 2022: 2 · 2020: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2012: 2
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universidad de Buenos Aires
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone replacement therapy, hypogonadism, lipoprotein profile, HDL cholesterol, HDL2, apolipoprotein A-I, hepatic lipase, LDL cholesterol, triglycerides, atherogenic risk, testosterone enanthate, cardiovascular risk
MeSH terms
Adult, Apolipoproteins B, Body Constitution, Estradiol, Humans, Hypogonadism, Lipase, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Testosterone, Time Factors, Triglycerides, Body Mass Index, Apolipoprotein A-I

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