Cited by 216Drug-Induced Hepatotoxicity and ProtectionPharmacovigilance and Adverse Drug ReactionsLiver Disease Diagnosis and Treatment

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Hepatotoxicity of Commonly Used Drugs: Nonsteroidal Anti-Inflammatory Drugs, Antihypertensives, Antidiabetic Agents, Anticonvulsants, Lipid-Lowering Agents, Psychotropic Drugs

Chitturi, Shivakumar, George, Jacob·2002·Seminars in Liver Disease

DOI 10.1055/s-2002-30102

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Abstract

Hepatotoxic adverse drug reactions have contributed to the decline of many promising therapies, even among mainstream medication classes (bromfenac and troglitazone are recent examples). The spectrum of nonsteroidal anti-inflammatory drug-related liver toxicity continues to expand, with reports in children, interactive toxicity in persons with hepatitis C, and recognition of the toxicity of both the preferential and selective cyclooxygenase-2 inhibitors. Of the antihypertensive agents, methyldopa is now rarely prescribed and adverse effects are reported infrequently, whereas cases of liver injury associated with the angiotensin receptor and converting enzyme inhibitors are increasingly reported. Of the antidiabetic agents, acarbose, gliclazide, metformin, and human insulin have been implicated in causing liver injury. To date, the newer thiazolidinediones do not appear to share the hepatotoxic potential of troglitazone, although a few reports of acute hepatitis have accrued. Although liver injury has been associated with the "statins," the frequency of such toxicity is lower than that of the background population and the value of biochemical monitoring remains unproved. Newer concepts in anticonvulsant hepatotoxicity have been the recognition of the reactive metabolite syndrome, delineation of the risk factors for valproic acid toxicity, the potential role of carnitine in preventing valproic acid hepatotoxicity, and the toxicity of second-line antiepileptic drugs. Liver injury associated with newer psychotropic agents, particularly the selective serotonin reuptake inhibitors, is also discussed. The focus of the review is the hepatotoxicity of commonly used drugs with particular reference to recent and novel reports of toxicity. Well-known causes of liver injury such as chlorpromazine, phenytoin, and methyldopa are not discussed.

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Clopidogrel‐Induced Hepatocellular Injury and Cholestatic Jaundice in an Elderly Patient: Case Report and Review of the Literature
Goyal, R. K., Srivastava, D., & Lessnau, K. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.5.608 · Cited by 28
Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review
Pachkoria, K., Lucena, M. I., Molokhia, M., Cueto-Galán, R., Carballo, A. S., Carvajal, A., & Andrade, R. J. (2007) · Current Drug Safety · doi:10.2174/157488607780598287 · Cited by 29
“Use of non- prescription, concomitant treatment, herbal or alternative medication may be important undereported risk factors [135, 136].”
Background
Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance
Zhou, S., Chan, E., Duan, W., et al. (2005) · Drug Metabolism Reviews · doi:10.1081/dmr-28812 · Cited by 29
Drug‐Induced Liver Injury
Seeff, L. B., & Fontana, R. J. (2011) · Wiley eBooks · doi:10.1002/9781444341294.ch24 · Cited by 29
Lupinus albus Conglutin Gamma Modifies the Gene Expressions of Enzymes Involved in Glucose Hepatic Production In Vivo
Santiago, A. E. G., Vargas‐Guerrero, B., García‐López, P. M., Ayala, A. L. M., Domı́nguez-Rosales, J. A., & Gurrola‐Díaz, C. M. (2017) · Plant Foods for Human Nutrition · doi:10.1007/s11130-016-0597-7 · Cited by 27
“The use of any drug for the treatment of glucose disorders can result in some kind of kidney and/or liver damage [24, 25].”
Background
Hepatic adverse drug reactions: a case/non-case study in Italy
Motola, D., Vargiu, A., Leone, R., Cocci, A., Salvo, F., Ros, B. Z., Meneghelli, I., Venegoni, M., Cutroneo, P. M., Vaccheri, A., et al. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-006-0222-z · Cited by 27
“The hepatic adverse effects of drugs such as acetaminophen and the antiepileptics carbamazepine, phenitoine and valproic acid [31, 32] are well recognised.”
Background
Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
Marzio, D. H., & Navarro, V. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-387817-5.00029-7 · Cited by 29
Metformin Hepatotoxicity
Deutsch, M. J., Kountouras, D., & Dourakis, S. P. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-5-200403020-00026-w1 · Cited by 27
Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling
Mattes, W. B., Kamp, H., Fabian, E. J., Herold, M. J., Krennrich, G., Looser, R., Mellert, W., Prokoudine, A., Strauss, V., van Ravenzwaay, B., et al. (2013) · BioMed Research International · doi:10.1155/2013/202497 · Cited by 26
“For example, phenytoin is associated with both acute and chronic liver injury in patients [41, 42] and is the third leading causative agent for acute liver failure requiring liver transplantation [43].”
Background
Digestive enzymes inhibition, antioxidant and antiglycation activities of phenolic compounds from jabuticaba (Plinia cauliflora) peel
Borges, L. L. R., de Oliveira, L. L., Freitas, V. V., et al. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102195 · Cited by 26
Review article: drug-induced hepatotoxicity.
Lee, W. M. (1993) · PubMed · Cited by 26
Association between antihypertensive drugs and hepatocellular carcinoma: A trans‐ancestry and drug‐target Mendelian randomization study
Wang, Z., Lu, J., & Hu, J. (2023) · Liver International · doi:10.1111/liv.15566 · Cited by 27
Mortality and drug exposure in a 5-year cohort of patients with chronic liver disease
Lipsitz, S., Seger, D., Karson, A., et al. (2009) · Swiss Medical Weekly · doi:10.4414/smw.2009.12686 · Cited by 25
Associations between co-exposure to per- and polyfluoroalkyl substances and metabolic diseases: The mediating roles of inflammation and oxidative stress
Chen, Z., Wei, W., Hu, Y., Niu, Q., & Yan, Y. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176187 · Cited by 26
Study of acute hepatotoxicity of Equisetum arvense L. in rats
Baracho, N. C. D. V., Vicente, B. B. V., Arruda, G. D. S., et al. (2009) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502009000600005 · Cited by 24
Mitochondrial Uncoupling by the Sulindac Metabolite, Sulindac Sulfide
Leite, S. T., Martins, N. M., Dorta, D. J., Curti, C., Uyemura, S. A., & dos Santos, A. C. (2006) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2006.pto_490.x · Cited by 24
New Ways to Detect Adverse Drug Reactions in Pediatrics
Rieder, M. J. (2012) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2012.07.010 · Cited by 24
Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner
Kim, M., Gu, G., Koh, Y.-S., et al. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.225 · Cited by 24
“Similarly, high levels of oxidative stress (Saeidnia and Abdollahi, 2013) and compromised liver function or dysfunction of diabetic patients resulted in increased susceptibility to liver toxicity of anti-diabetic drugs (Chitturi and George, 2001; El-serag et al., 2004; Gupte et al., 2004).”
Background
Mitochondrial toxicity of selective COX-2 inhibitors via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria
Syed, M., Skonberg, C., & Hansen, S. H. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.12.003 · Cited by 23
The safety of rosuvastatin: effects on renal and hepatic function
Guthrie, R. M., & Martin, D. R. (2007) · Expert Opinion on Drug Safety · doi:10.1517/14740338.6.5.573 · Cited by 20
Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury
Li, X., Gao, P., & Niu, J. (2019) · BioMed Research International · doi:10.1155/2019/8764093 · Cited by 19
“The oral antidiabetic agents, acarbose [115] and gliclazide [116], have also been implicated in liver toxicity [108].”
Background
Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac)
Villaverde, A. F., Benlloch, S., Berenguer, M., et al. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.07.006 · Cited by 18
Evaluation of Database-Derived Pathway Development for Enabling Biomarker Discovery for Hepatotoxicity
Hebels, D. G. A. J., Jetten, M. J., Aerts, H. J. W. L., Herwig, R., Theunissen, D. H. J., Gaj, S., van Delft, J. H. M., & Kleinjans, J. C. S. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.13.154 · Cited by 18
Simvastatin Reduces Capsular Fibrosis around Silicone Implants
Chung, K. J., Park, K. R., Lee, J. H., Kim, T. G., & Kim, Y. (2016) · Journal of Korean Medical Science · doi:10.3346/jkms.2016.31.8.1273 · Cited by 18
“Simvastatin has been associated with liver injury, such as acute hepatitis, cholestatic hepatitis, and acute liver failure (25,26).”
Background
Plant Secondary Metabolites With Hepatoprotective Efficacy
Gupta, A., & Pandey, A. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816450-1.00003-9 · Cited by 21
Hepatotoxicidad secundaria a fármacos de uso común
García‐Cortés, M., Andrade, R. J., Lucena, M. I., González‐Grande, R., Camargo, R., Bonilla, E. M. F., Martos, J. V., & Alcántara, R. (2005) · Gastroenterología y Hepatología · doi:10.1157/13079002 · Cited by 19
Difficulty with diagnosis of malignant pancreatic neoplasms coexisting with chronic pancreatitis
Leung, T., Lee, C., Wang, F.-C., Chen, H.-C., & Wang, H. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i32.5075 · Cited by 18
Association Between Antipsychotic-induced Elevation of Liver Enzymes and Weight Gain
Rettenbacher, M. A., Baumgartner, S., Eder, U., Edlinger, M., Graziadei, I. W., Hofer, A., Huber, R., Hummer, M., Kemmler, G., Weiss, E. M., et al. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000236654.85791.ae · Cited by 16
“Elevation of liver enzymes in these cases has been found to be mild and transient, not requiring discontinuation of treatment.(4) Chi-UnPae et al(5) have investigated an Asian sample with respect to changes of liver enzymes during treatment with olanzapine versus risperidone retrospectively.”
Background
Cholestatic syndromes
Trauner, M., & Boyer, J. L. (2003) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200305000-00005 · Cited by 15
The Effects of Fentanyl on Hepatic Mitochondrial Function
Djafarzadeh, S., Vuda, M., Jeger, V., et al. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001280 · Cited by 15
Autoimmune-like Drug-induced Liver Injury Caused by Atorvastatin and Demonstration of the Safety Profile of Pravastatin: A Case Report and Literature Review
Khan, A. A., Ahmed, S., Mohammed, A., et al. (2020) · Cureus · doi:10.7759/cureus.7299 · Cited by 14
Drug-Induced Liver Injury
Bonkovsky, H. L., Jones, D. P., Russo, M. W., & Shedlofsky, S. I. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00025-5 · Cited by 22
Metformin-Associated Lactic Acidosis in a Burn Patient
Riesenman, P. J., Braithwaite, S. S., & Cairns, B. A. (2007) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e318031a1fe · Cited by 14
“Additionally, although selective serotonin reuptake inhibitors can cause acute hepatitis and elevations in aminotransferases, this is rare, and there are no reports of these complications associated with citalopram.(26) Although several of the patient’s medications were hepaticly metabolized, this would not be expecte…”
Background
Mitigation of statins-induced cytotoxicity and mitochondrial dysfunction by L-carnitine in freshly-isolated rat hepatocytes.
Abdoli, N., Azarmi, Y., & Eghbal, M. A. (2015) · PubMed · Cited by 14
Drug‐Induced Liver Disease
Chitturi, S., & Farrell, G. C. (2011) · Wiley eBooks · doi:10.1002/9781119950509.ch27 · Cited by 14
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Martins, M. (2011) · Recent Patents on Anti-Infective Drug Discovery · doi:10.2174/157489111796064524 · Cited by 13
Six Months of Treatment with Risperidone May Be Associated with Nonsignificant Abnormalities of Liver Function Tests in Children and Adolescents: A Longitudinal, Observational Study from Turkey
Erdoğan, A., Karaman, M. G., Özdemir, E., Yurteri, N., Tufan, A. E., & Kurçer, M. A. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0113 · Cited by 13
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Drug-Induced Liver Injury
Bonkovsky, H. L., Jones, D. P., LaBrecque, D. R., & Shedlofsky, S. I. (2006) · Elsevier eBooks · doi:10.1016/b978-1-4160-3258-8.50031-0 · Cited by 12
Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice
Tsuchiya, H., Sato, J., Tsuda, H., et al. (2013) · Toxicology · doi:10.1016/j.tox.2013.01.012 · Cited by 11
Late-onset cholestatic hepatitis induced by olanzapine in a patient with schizophrenia
Hung, C.-C., Wei, I., & Huang, C. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.09.011 · Cited by 11
“In addition to gender, other factors that can delay the clearance of olanzapine include geriatric age, non-smoking status, polymedication, substance use, hepatic disorders, obesity, viral infection, and agranulocytosis (Bigos et al., 2008; Chitturi and George, 2002).”
Successful Treatment of Fosinopril-Induced Severe Cholestatic Jaundice with Plasma Exchange
Chou, J., Yu, C., Chuang, P., Lai, H., Hsu, C.-H., Cheng, K.-S., Peng, C.-Y., & Chiang, I. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1l229 · Cited by 11
Hepatic and renal toxicities of indomethacin acid, salt form and complexed forms with hydroxypropyl‐β‐cyclodextrin on Wistar rats after oral administration
Ribeiro‐Rama, A. C., Figueiredo, I. V., Veiga, F., et al. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00887.x · Cited by 10
Effect of Coccinia indica leaf extract on angiotensin converting enzyme (ACE) inhibitor induced hepatotoxicity in wistar albino rats
Vinothkumar, G., Venkataraman, P., Vinodhini, V. M., Lavanya, R., & Sathishkumar, D. (2019) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2019.01.004 · Cited by 10
Effect of acarbose on alanine aminotransferase and aspartate aminotransferase activities in the liver of control and diabetic CBA mice.
Petlevski, R., Hadžija, M., Bajalo, J. L., et al. (2006) · PubMed · Cited by 9
Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System.
Jazaeri, F., Sheibani, M., Nezamoleslami, S., Moezi, L., & Dehpour, A. R. (2021) · Europe PMC (PubMed Central) · doi:10.22037/ijpr.2020.113362.14254 · Cited by 9
Statines : quelle hépatotoxicité et quelle surveillance?
Cadranel, J., Seddik, M., Loric, S., et al. (2009) · La Presse Médicale · doi:10.1016/j.lpm.2008.05.022 · Cited by 8
Hígado y deporte
Bruguera, M. (2004) · Medicina Clínica · doi:10.1016/s0025-7753(04)74159-7 · Cited by 8
Anti-Retroviral Drug Hepatotoxicity and Risk Factors in HIV Patients with or Without Hepatitis B and C: A Review
Wambani, J. R., & Ogola, P. E. (2015) · Journal of Infectious Diseases and Therapy · doi:10.4172/2332-0877.1000258 · Cited by 8
“NNRTIs are associated with a rash and lipid disorders [1,38,39].”
BackgroundInfluential
Clinical and Nonclinical Adverse Effects of Kinase Inhibitors
Keller, D. A., Brennan, R., & Leach, K. L. (2015) · Methods and principles in medicinal chemistry · doi:10.1002/9783527673643.ch16 · Cited by 8
Effect of combined therapy of diabinese and nicotinic acid on liver enzymes in rabbits with dithizone-induced diabetes
Erhabor, O. (2010) · Journal of Experimental Pharmacology · doi:10.2147/jep.s11490 · Cited by 6
Use of Hepatotoxic Drugs in Chronic Liver Disease
Hug, B. L., Surber, C., & Bates, D. W. (2012) · Journal of Patient Safety · doi:10.1097/pts.0b013e3182482df2 · Cited by 6
“41,44 In rare cases, submassive to massive hepatic necrosis has been observed (indomethacin, labetalol, nicotinic acid, valproic acid, and trazodone).(41)”
Background
DM‐induced Hypermethylation of IR and IGF1R attenuates mast cell activation and airway responsiveness in rats
Fu, D. B., Zhao, H., He, L., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16059 · Cited by 6
Repositioned Drugs for COVID-19—the Impact on Multiple Organs
Chan, C., Foster, S. T., Chan, K. G., Cacace, M. J., Ladd, S., Sandum, C. T., Wright, P. T., Volmert, B. D., Yang, W., Aguirre, A., et al. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-00874-8 · Cited by 5
Identification of classifier genes for hepatotoxicity prediction in non steroidal anti inflammatory drugs
Jin, H., Ko, M.-J., Ahn, S.-M., Ahn, J., Shin, H. J., Jeong, H., Kim, H. S., Choi, S. O., & Kim, E. J. (2010) · Molecular & Cellular Toxicology · doi:10.1007/s13273-010-0034-1 · Cited by 6
Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism
Davies, G. F. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00082-3 · Cited by 6
Drug Class Review: Thiazolidinediones
Norris, S. L., Carson, S., Thakurta, S., & Chan, B. K. S. (2008) · Cited by 6
Hepatitis following famotidine: a case report
Gupta, N., Patel, C., & Panda, M. (2009) · Cases Journal · doi:10.1186/1757-1626-2-89 · Cited by 6
“Hepatotoxicity can occur with many drugs through a variety of mechanisms and can present with an array of clinical presentations ranging from asymptomatic mild biochemical abnormalities to an acute illness that resembles viral hepatitis [2,3].”
Background
The Role of Drug Metabolism in Toxicity
Hanumegowda, U., & Davis, C. D. (2022) · Wiley eBooks · doi:10.1002/9781119851042.ch19 · Cited by 7
Impact of lipid lowering therapy on liver function
Paragh, G., & Fülöp, P. (2009) · Orvosi Hetilap · doi:10.1556/oh.2009.28629 · Cited by 5
Hepatocellular Necrosis Associated With Labetalol
Long, R. C., Wofford, M. R., Harkins, K. G., & Minor, D. S. (2007) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2007.06351.x · Cited by 5
Biopsy-confirmed fenofibrate-induced severe jaundice: A case report
Lee, H. Y., Lee, A.-R., Yoo, J., et al. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i30.9295 · Cited by 5
Effects of statins on cholestasis: Good, bad or indifferent?
Kuver, R. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06836.x · Cited by 4
“This side effect is usually asymptomatic and reversible after dosage reduction or drug withdrawal [1].”
Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides
Ali, R., & Siddiqui, N. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/194652 · Cited by 4
“Phenytoin is a probable cause of acetaminophen hepatotoxicity [24] and anticonvulsants such as carbamazepine [25] and valproic acid [26] were also expected to enhance or show hepatotoxicity as a major side effect.”
Background
Toxicity of Oral Agents Used to Treat Diabetes
Lada, P., & Idrees, U. (2005) · Journal of Pharmacy Practice · doi:10.1177/0897190005277239 · Cited by 4
“All cases of hepatotoxicity have developed within 2 to 4 weeks after initiation, and discontinuation resulted in complete resolution in all cases.(32) Metformin causes a small increase in basal and postprandial blood lactate concentration, which is most likely caused by metformin-induced conversion of glucose to lacta…”
BackgroundMethodInfluential
Drug-Induced Liver Injury
Devarbhavi, H. C., Bonkovsky, H. L., Russo, M. W., & Chalasani, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00056-2 · Cited by 5
Hepatotoxicity Implies Chemical-Driven Liver Damage Induced By Certain Medicinal and Other Chemical Agents
(2015) · American Research Journal of Pharmacy · doi:10.21694/2380-5706.15001 · Cited by 4
Management of NASH: Current and Future Perspectives on Treatment
Angulo, P., & Lindor, K. D. (2004) · doi:10.1002/9780470987438.ch16 · Cited by 4
Detrimental Effect of C-Reactive Protein on the Cardiometabolic Cells and Its Rectifying by Metabolic Surgery in Obese Diabetic Patients
Sun, F., Zhao, Z., Li, Q., Zhou, X., Li, Y., Zhang, H., Yan, Z., He, H., Ke, Z., Gao, Y., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s250294 · Cited by 3
Intracellular reorganization of hepatocytes during doxorubicin treatment
Molodykh, O. P., Lushnikova, E. L., Клинникова, М. Г., et al. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0382-6 · Cited by 3
En mann i 30-årene med icterus og kløe
Huppertz‐Hauss, G., Brekke, H., Holmberg, M., et al. (2014) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.13.1215 · Cited by 3
Effectiveness of a new rutin Cu(II) complex in the prevention of lipid peroxidation and hepatotoxicity in hypercholesterolemic rats
Oliveira, D. A. F., Diniz, S. N., Pereira, R. M. S., Gonçalves, I. D., Rennó, A. L., Gorjão, R., Vieira, E. G., Ferreira, A. M. D. C., & Okuyama, C. E. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13999 · Cited by 3
Gastrointestinal and Hepatic Complications
Strasser, S. I., & McDonald, G. B. (2003) · Wiley eBooks · doi:10.1002/9780470987070.ch58 · Cited by 3
The Role of Drug Metabolism in Toxicity
Davis, C. D., & Hanumegowda, U. (2008) · Wiley eBooks · doi:10.1002/9780470439265.ch21 · Cited by 3
Statin-induced adverse effects – facts and genes
Harangi, M., Zsíros, N., Juhász, L., & Paragh, G. (2013) · Orvosi Hetilap · doi:10.1556/oh.2013.29530 · Cited by 3
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EnayetAllah, A. E. (2015) · Journal of Proteomics & Bioinformatics · doi:10.4172/jpb.1000352 · Cited by 2
“A wide variety of drugs can result in liver injury, including antibiotics, CNS drugs and non-steroidal anti-inflammatory drugs (NSAIDS) [1].”
Background
Hepatotoxicity From Disease-Modifying Anti-rheumatic Drugs (DMARDs) and Association With Metabolic Syndrome in Rheumatoid Arthritis
Nandan, A., Haritha, J., Maniscalco, D., et al. (2025) · Cureus · doi:10.7759/cureus.78626 · Cited by 2
“The risk of hepatotoxicity may have been confounded by a number of additional medications including anti-inflammatory medications, diabetic medications, anti-hypertensive medications, and psychotropic medications which can intermittently lead to hepatotoxicity in some patients [12].”
Cholestasis, Contraceptives, and Free Radicals
Fernández‐Martínez, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804274-8.00018-7 · Cited by 2
Gastrointestinal Pharmacology
Cimino, M. A., Johnson, K. K., & Michienzi, K. A. (2006) · Elsevier eBooks · doi:10.1016/b978-032301808-1.50083-3 · Cited by 2
Gastrointestinal Pharmacology
Bystrak, L. L., Heine, A. M., Michienzi, K. A., & Stojanovski, S. D. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-07307-3.10087-4 · Cited by 2
CHOLANGITIS AND CHOLECYSTITIS
McLin, V. A., Soden, J. S., & Karpen, S. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4044-6.50059-5 · Cited by 2
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Siebert, S., Elkeles, B., Hempel, G., et al. (2013) · Zeitschrift für Gerontologie und Geriatrie · Cited by 2
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Achuthanandan, S., Dhaliwal, A., & Patti, R. (2022) · Cureus · doi:10.7759/cureus.27005 · Cited by 2
“Acarbose is an alpha-glucosidase inhibitor and has a known dose-dependent hepatotoxic effect occurring months after exposure to the drug [2].”
BackgroundResult
Drugs and Toxins Effects on the Liver
Luigi, P., Licata, A., & Randazzo, C. (2011) · InTech eBooks · doi:10.5772/19468 · Cited by 2
The Role of Drug Metabolism in Toxicity
Davis, C. D., & Hanumegowda, U. (2010) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse120 · Cited by 2
Cholestatic syndrome in patients with systemic erythematous lupus: Differential diagnostic aspects
Tomašević, R., Golubovic, G., Kiurski, M., et al. (2008) · Medicinski pregled · doi:10.2298/mpns0806291t · Cited by 1
Efeitos da sinvastatina na hipertrofia lipídica da medula óssea induzida pelo uso de corticóides em ratos
de Oliveira, L. P., Penteado, L. O. S., de Carvalho, J. J., et al. (2007) · Revista Brasileira de Ortopedia · doi:10.1590/s0102-36162007001100005 · Cited by 1
“Os efeitos colaterais mais importantes dos inibidores da HMG-CoA redutase são a toxicidade hepática e muscular(34).”
BackgroundInfluential
Design and synthesis of stable n-[2-(aryl/heteroaryl substituted)ethyl] propanamide derivatives of (s)-ketoprofen and (s)-ibuprofen as non-ulcerogenic anti-inflammatory and analgesic agents
Berk, B., Bender, C., Akkol, E. K., et al. (2016) · ACTA Pharmaceutica Sciencia · doi:10.23893/1307-2080.aps.0546 · Cited by 1
Syndrome of intrahepatic cholestasis in patients with acute and chronic intoxication with pesticides
Bubalo, N., & Балан, Г. М. (2018) · Ukrainian Journal of Modern Toxicological Aspects · doi:10.33273/2663-4570-2018-81-1-39-48 · Cited by 1
Side Effects and Biochemical Changes in Rat Liver on Drug Treatment
(2016) · International Journal of Science and Research (IJSR) · doi:10.21275/v5i2.nov161056 · Cited by 1
“Although the occurrence of drug induced hepatotoxicity is difficult to predict, it has been observed that certain patients are at higher risk during the course of anti-TB chemotherapy ( Stolk et al,2006 and Chitturi & George,2002).”
Background
Mellow Yellow: Diagnosis and Management of Multifactorial Postoperative Jaundice
Tandon, A., Roorda, A. K., Legha, P., et al. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3946-8 · Cited by 1
“Drug-induced liver injury is also a common reason for postoperative jaundice; many drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), antidiabetics, antihypertensives, xenobiotics, or toxins may be involved [8–10].”
Background
Fenofibrate Potentiates the Antihyperglycemic, Antidyslipidemic and Hepatoprotective Activity of Pioglitazone on Alloxan-Induced Diabetic Rats
Rashid, M., Islam, M. T., Rahman, A. F. M. T., et al. (2015) · Pharmacologia · doi:10.5567/pharmacologia.2016.53.59 · Cited by 1
Evaluation of Hypolipidemic and TNF-α Lowering Effect of Ficus Religiosa in Dyslipidemic Wistar Rats
Nath, R. (2019) · Current Research in Diabetes & Obesity Journal · doi:10.19080/crdoj.2019.10.555799 · Cited by 1
“However, modern allopathic drugs, in general have not been a concrete solution till date, because commonly used hypolipidemic drugs are costly and have inadvertently produced serious adverse effects [9].”
Background
Pathophysiology of Endogenous Toxins and Their Relation to Inborn Errors of Metabolism and Drug‐Mediated Toxicities
Subrahmanyam, V. (2009) · doi:10.1002/9783527628100.ch12 · Cited by 1
Adverse Drug Reactions in Dogs – Toxic Hepatic Responses
Woodward, K. (2009) · doi:10.1002/9781444322958.ch18 · Cited by 1
Liver Disease in Renal Transplant Recipients
Said, A., Safdar, N., Wells, J. T., & Lucey, M. R. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-3343-1.50034-7 · Cited by 1
Liver Disease Among Renal Transplant Recipients
Said, A., Safdar, N., & Lucey, M. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-53186-3.00032-2 · Cited by 1
Hepatorenal Effects of Ibuprofen Compared with other NSAIDs and Paracetamol
Rainsford, K. D. (2015) · doi:10.1002/9781118743614.ch10
Pharmacology of ketoprofen administered orally to pigs: an experimental and clinical study
Mustonen, K. (2012) · Työväentutkimus Vuosikirja
Significado clínico de los autoanticuerpos en pacientes con síndrome de Sjögren primario
Nardi, N. N. (2011) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)
Hepatic Failure-induced Hypogonadism in a Prostate Cancer Patient
Li, C.-C., Yang, C., Yu, C., Chen, C.-S., Cheng, C., Ou, Y., Ho, H., Hung, S.-W., & Li, J. (2010) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(10)70083-6

Authors: Chitturi, S., & George, J.
Affiliations: The University of Sydney (AU)
ORCID: Chitturi, Shivakumar
George, Jacob
Venue: Seminars in Liver Disease
Publisher: Georg Thieme Verlag KG
Published: 2002-05-16
Volume: 22
Issue: 02
Pages: 169-184
ISSN: 0272-8087 (ISSN-L)
1098-8971
DOI: 10.1055/s-2002-30102
OpenAlex: W1996604226
Cited by: 216
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 14 · 2014: 8 · 2013: 10 · 2012: 10
FWCI: 10.39
Type: journal article
Language: en
Open access: closed
Locations: Seminars in Liver Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: drug-induced liver injury, hepatotoxicity, adverse drug reactions, nonsteroidal anti-inflammatory drugs, COX-2 inhibitors, antihypertensive drugs, angiotensin receptor blockers, ACE inhibitors, methyldopa, antidiabetic drugs, thiazolidinediones, troglitazone, statins, antiepileptic drugs, L-carnitine, selective serotonin reuptake inhibitors, psychotropic drugs, hepatitis C
MeSH terms: Adult, Anti-Inflammatory Agents, Non-Steroidal, Anticonvulsants, Antihypertensive Agents, Hypolipidemic Agents, Child, Cholestasis, Humans, Hypoglycemic Agents, Liver, Psychotropic Drugs, Liver Failure

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Hepatotoxicity of Commonly Used Drugs: Nonsteroidal Anti-Inflammatory Drugs, Antihypertensives, Antidiabetic Agents, Anticonvulsants, Lipid-Lowering Agents, Psychotropic Drugs

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