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Trimipramine in Primary Insomnia: Results of a Polysomnographic Double-Blind Controlled Study
Abstract
In recent years, sedating antidepressants have been increasingly used to treat primary insomnia. Up to now, only one open pilot study with trimipramine and one double-blind placebo-controlled study with doxepin have provided scientific support for this approach in treating primary insomnia. In order to test the hypothesis that sedating antidepressants are useful in the treatment of primary insomnia, the effect of trimipramine on objectively and subjectively measured parameters of sleep was investigated in a double-blind placebo- and lormetazepam-controlled study in a sample of 55 patients with primary insomnia attending outpatient sleep-disorder clinics. Trimipramine was selected since it has shown positive effects on sleep continuity with a lack of REM sleep suppression in studies on depressed patients and in one pilot study on patients with primary insomnia. Trimipramine at an average dose of 100 mg over a period of 4 weeks significantly enhanced sleep efficiency, but not total sleep time (which had been the primary target variable) compared to placebo as measured by polysomnography. Changes in objective sleep parameters were paralleled by changes in subjective sleep parameters. Trimipramine did not suppress REM sleep. Lormetazepam decreased wake time and sleep stage 3 and increased REM sleep compared to placebo. After switching trimipramine to placebo, sleep parameters returned to baseline. There was no evidence of any rebound effect from trimipramine. Side effects from tr…
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“Evidence for their efficacy when used alone is relatively weak 38-42 and no specific agent within this group is recommended as preferable to the others in this group.”
From Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults (2008) · cites this paper as [39]
In the citing paper
“(Riemann et al., 2002) found that trimipramine (mean 100mg) was not associated with REM sleep suppression, when compared to placebo with insomnia patients.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Riemann et al., 2002
In the citing paper
“REM sleep suppression is reported with all TCAs except trimipramine (Riemann et al., 2002).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Riemann et al., 2002
Citations
Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.262.11.1479 · Cited by 2,440
Effect of benzodiazepine hypnotics on all-night sleep EEG spectra.
Borbély, A. A., Mattmann, P., Loepfe, M., Strauch, I., & Lehmann, D. (1985) · PubMed · Cited by 230
Hajak, G., Rodenbeck, A., Voderholzer, U., Riemann, D., Cohrs, S., Hohagen, F., Berger, M., & Ruther, E. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0609 · Cited by 199
Self-citationTrimipramine: A challenge to current concepts on antidepressives
Berger, T., & Gastpar, M. (1996) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190274 · Cited by 190
REM sleep in depression—an overview
Berger, M., & Riemann, D. W. (1993) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1993.tb00092.x · Cited by 138
Self-citationLong-term effectiveness of a short-term cognitive-behavioral group treatment for primary insomnia
Backhaus, J., Hohagen, F., Voderholzer, U., & Riemann, D. W. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170066 · Cited by 127
Self-citationGillin, J. C., Rapaport, M., Erman, M. K., Winokur, A., & Albala, B. J. (1997) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v58n0502 · Cited by 104
The Effects of Nefazodone on Sleep Architecture in Depression
Armitage, R., Rush, A. J., Trivedi, M., Cain, J., & Roffwarg, H. P. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.14 · Cited by 102
Armitage, R., Yonkers, K., Cole, D., & Rush, A. J. (1997) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199706000-00004 · Cited by 97
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Hypnotics: Definition, Classifications, Indications, and Differential Indications
Dietmaier, O. (2021) · NeuroPsychopharmacotherapy · doi:10.1007/978-3-319-56015-1_432-1 · Cited by 1
Hypnotics: Guidelines and Current References
Bergemann, N. (2022) · Springer eBooks · doi:10.1007/978-3-319-56015-1_77-1 · Cited by 2
Tricyclics: Imipramine, Clomipramine, Trimipramine (Dibenzazepines)
Volz, H., & Laux, G. (2022) · Springer eBooks · doi:10.1007/978-3-319-56015-1_385-1 · Cited by 1
Trizyklische Antidepressiva als Schlafmittel. Medikamentöse Behandlungsoptionen bei Insomnie
Doerr, J., & Riemann, D. (2008) · Pharmazie in unserer Zeit · doi:10.1002/pauz.200800266
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Krystal, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00088-x · Cited by 5
Prescribing patterns of antidepressants with known off–label indications among adults
Roux, L., & Daniël, J. (2014) · Cited by 1
Pharmacologic Treatment of Insomnia
Neubauer, D. N. (2008) · Wiley eBooks · doi:10.1002/9780470515167.ch105 · Cited by 1
Pharmacologic Treatment of Insomnia
Monderer, R., Harris, S., & Thorpy, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-378610-4.00200-x
Depressive Kernsymptome : Wirksamkeit medikamentöser antidepressiver Therapieverfahren
Damm, J., Eser, D., Schüle, C., Möller, H.-J., Rupprecht, R., & Baghai, T. C. (2009) · Der Nervenarzt · Cited by 1
Self-citationHolshoe, J. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-378610-4.00121-2 · Cited by 1
Laux, G., & Dietmaier, O. (2006) · Elsevier eBooks · doi:10.1016/b978-343721063-1.50028-7
Pharmakotherapie der Insomnie im höheren Lebensalter
Schlitzer, J., Heubaum, S., & Frohnhofen, H. (2014) · Schlaf · doi:10.1055/s-0038-1626102
Der Einfluss von Ziprasidon auf den Schlaf und die Kortisolexkretion
Neumann, A.-C. H. (2007) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-699
WPA Bulletin on Depression WPA Bulletin on Depression
Moussaoui, D., Hamaoui, Y. E., Lenzi, G. L., Troisi, P., Altieri, M., Fountoulakis, K. Ν., & Karanikiotis, C. (2007)
Pharmacological Treatments of Insomnia
Dokucu, M. E. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-324-4_9
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der Schlafregulation, G. (2013)
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Frase, L., & Nissen, C. (2013) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-013-0251-2
Spiegelhalder, K., Hirscher, V., Unbehaun, T., Hajak, G., & Riemann, D. W. (2012) · Elsevier eBooks · doi:10.1016/b978-3-437-24903-7.10018-6
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Riemann, D., Spiegelhalder, K., Perlis, M. L., & Hajak, G. (2007) · Elsevier eBooks · doi:10.1016/b978-343724131-4.50019-6
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Wilson, S. J., & Selsick, H. (2018) · Springer eBooks · doi:10.1007/978-3-642-54836-9_8
Insomnia and sleep medications
Randall, S. (2013) · doi:10.3920/978-90-8686-763-9_3
Schlafstörungen bei Depression. Behandlungsmöglichkeiten
Zimmermann, C., & Pfeiffer, H. (2007) · Der Nervenarzt
Riemann, D., Spiegelhalder, K., Hornyak, M., Berger, M., & Voderholzer, U. (2015) · Elsevier eBooks · doi:10.1016/b978-3-437-22484-3.00019-0
Self-citationSpiegelhalder, K., Perlis, M. L., Hajak, G., & Riemann, D. W. (2009) · Elsevier eBooks · doi:10.1016/b978-3-437-24900-6.50020-4
Self-citationHolshoe, J. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00073-6
Schiefer, J. (2006) · Springer eBooks · doi:10.1007/3-540-28604-7_7
Arnold, I. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6605
Pharmacologic treatment of insomnia
Harris, S., Thorpy, M., & Monderer, R. (2021) · Reference Module in Neuroscience and Biobehavioral Psychology · doi:10.1016/b978-0-12-822963-7.00101-8
Fink, H. (2006) · Springer eBooks · doi:10.1007/3-540-35149-3_26
Fink, H., & Hellweg, R. (2007) · Springer-Lehrbuch · doi:10.1007/978-3-540-34181-9_27
Laux, G., & Dietmaier, O. (2006) · Elsevier eBooks · doi:10.1016/b978-343721063-1.50040-8
Tricyclics: Imipramine, Clomipramine, Trimipramine (Dibenzazepines)
Volz, H., & Laux, G. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_385
Xia, M., Xu, Z., Yang, X., Zou, Y., Xu, Y., Tan, Y., Yan, R., Xu, J., Song, Y., Liu, Y., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4800402
Chapter 58. Treatment of Insomnia
Krystal, A. D. (2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375523.as58
Herberger, S., & Wiegand, M. H. (2020) · Springer Reference Medizin · doi:10.1007/978-3-642-54672-3_280-1
Self-citationHerberger, S., & Wiegand, M. H. (2025) · Springer Reference Medizin · doi:10.1007/978-3-662-65186-5_280
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Groß, G., & Stübner, S. (2026) · Forensische Psychiatrie Psychologie Kriminologie · doi:10.1007/s11757-026-00926-6
Recommendations on switching or deprescribing hypnotic medications for insomnia
Hajak, G., Fietze, I., Schöbel, C., Saletu, M., Högl, B., & Winter, Y. (2026) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2026.0141
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Metadata
- Authors
- Riemann, D., Voderholzer, U., Cohrs, S., Rodenbeck, A., Hajak, G., Rüther, E., Wiegand, M. H., Laakmann, G., Baghai, T., Fischer, W., Hoffmann, M., Hohagen, F., Mayer, G., & Berger, M.
- Affiliations
- University of Freiburg (DE)
- University of Göttingen (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Lübeck (DE)
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2002-09
- Volume
- 35
- Issue
- 5
- Pages
- 165-174
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W1987429320
- Cited by
- 145
- References
- 11
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 8
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- GRO (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- trimipramine, primary insomnia, sedating antidepressants, lormetazepam, sleep efficiency, REM sleep suppression, sleep continuity, rebound effect, antidepressant side effects
- MeSH terms
- Adult, Antidepressive Agents, Tricyclic, Benzodiazepines, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Lorazepam, Male, Middle Aged, Sleep Stages, Sleep, REM, Anti-Anxiety Agents, Trimipramine, Treatment Outcome, Polysomnography
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