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Two Flavonols from Artemisa annua which Potentiate the Activity of Berberine and Norfloxacin Against a Resistant Strain of Staphylococcus aureus
Abstract
Bioassay-guided fractionation of an extract of Artemisia annua L. (Asteraceae) was conducted in order to assess the possible presence in the plant material of inhibitors of bacterial multidrug resistance pumps. Fractions were tested for Staphylococcus aureus growth inhibition in the presence of a subinhibitory dose of the weak antibacterial alkaloid berberine. Active fractions yielded the flavones chrysosplenol-D and chrysoplenetin, which themselves had very weak growth inhibitory action, but which made a potent combination with berberine. In comparison with work on other flavonols, it is likely that potentiation is due to the inhibition of an S. aureus multidrug resistance (MDR) pump. These same two flavonols were earlier reported to potentiate the activity of artemisinin against Plasmodium falciparum.
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“These flavones include: casticin (227), artemetin (228) [91], chrysosplenol D (225) and chrysoplenetin (226) [92]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [92]
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Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Vaou, N., Stavropoulou, E., Voidarou, C. C., Tsigalou, C., & Bezirtzoglou, E. (2021) · Microorganisms · doi:10.3390/microorganisms9102041 · Cited by 1,132
Efflux-Mediated Drug Resistance in Bacteria
Li, X.-Z., & Nikaido, H. (2009) · Drugs · doi:10.2165/11317030-000000000-00000 · Cited by 1,022
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
Caesar, L. K., & Cech, N. B. (2019) · Natural Product Reports · doi:10.1039/c9np00011a · Cited by 1,003
Multidrug Tolerance of Biofilms and Persister Cells
Lewis, K. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-75418-3_6 · Cited by 838
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Metadata
- Authors
- Stermitz, F. R., Scriven, L. N., Tegos, G., & Lewis, K.
- Affiliations
- Colorado State University (US)
- Northeastern University (US)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2002-12
- Volume
- 68
- Issue
- 12
- Pages
- 1140-1141
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2039587632
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Colorado State University
- National Institutes of Health (5r01gm059903-03)
- National Institute of General Medical Sciences (R01 GM 59903)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Keywords
- Artemisia annua, flavonols, berberine, norfloxacin, Staphylococcus aureus, multidrug resistance, efflux pump inhibitors, bioassay-guided fractionation
- MeSH terms
- Anti-Infective Agents, Berberine, Drug Synergism, Flavonoids, Norfloxacin, Plant Extracts, Staphylococcus aureus, Molecular Structure, Drug Resistance, Bacterial, Artemisia annua
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