Cited by 114Bioactive natural compoundsEssential Oils and Antimicrobial ActivitySesquiterpenes and Asteraceae Studies

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Two Flavonols from Artemisa annua which Potentiate the Activity of Berberine and Norfloxacin Against a Resistant Strain of Staphylococcus aureus

Stermitz, Frank R., Scriven, Lacey N., Tegos, George, Lewis, Kim·2002·Planta Medica

DOI 10.1055/s-2002-36347

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Abstract

Bioassay-guided fractionation of an extract of Artemisia annua L. (Asteraceae) was conducted in order to assess the possible presence in the plant material of inhibitors of bacterial multidrug resistance pumps. Fractions were tested for Staphylococcus aureus growth inhibition in the presence of a subinhibitory dose of the weak antibacterial alkaloid berberine. Active fractions yielded the flavones chrysosplenol-D and chrysoplenetin, which themselves had very weak growth inhibitory action, but which made a potent combination with berberine. In comparison with work on other flavonols, it is likely that potentiation is due to the inhibition of an S. aureus multidrug resistance (MDR) pump. These same two flavonols were earlier reported to potentiate the activity of artemisinin against Plasmodium falciparum.

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Authors: Stermitz, F. R., Scriven, L. N., Tegos, G., & Lewis, K.
Affiliations: Colorado State University (US)
Northeastern University (US)
ORCID: Tegos, George
Lewis, Kim
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 2002-12
Volume: 68
Issue: 12
Pages: 1140-1141
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2002-36347
OpenAlex: W2039587632
Cited by: 114
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 9
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Funders: Colorado State University
National Institutes of Health (5r01gm059903-03)
National Institute of General Medical Sciences (R01 GM 59903)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords: Artemisia annua, flavonols, berberine, norfloxacin, Staphylococcus aureus, multidrug resistance, efflux pump inhibitors, bioassay-guided fractionation
MeSH terms: Anti-Infective Agents, Berberine, Drug Synergism, Flavonoids, Norfloxacin, Plant Extracts, Staphylococcus aureus, Molecular Structure, Drug Resistance, Bacterial, Artemisia annua

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Two Flavonols from Artemisa annua which Potentiate the Activity of Berberine and Norfloxacin Against a Resistant Strain of Staphylococcus aureus

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