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CABG and Bone Marrow Stem Cell Transplantation after Myocardial Infarction
Abstract
OBJECTIVE: Bone marrow-derived adult stem cells may be able to regenerate infarcted myocardium. We initiated a phase-I study of autologous stem cell transplantation in patients undergoing coronary artery bypass grafting. METHODS: Inclusion criteria were: acute myocardial infarction > 10 days ago; presence of a distinct area of infarcted and akinetic myocardium; CABG indicated to treat ischemia of other LV wall areas. Stem cells were isolated from bone marrow using a ferrite-conjugated AC133 antibody, and were injected in the infarct border zone during the CABG operation. RESULTS: To date, 12 patients were treated without major complications. There is no evidence of new ventricular arrhythmia or neoplasia. Scintigraphic imaging demonstrated significantly improved local perfusion in the stem cell-treated infarct area. LV dimensions (LVEDV 140 +/- 38 ml vs. 124 +/- 30 ml, p = 0.004, paired t-test) and LV ejection fraction (39.7 +/- 9 % vs. 48.7 +/- 6 %, p = 0.007) have improved. CONCLUSIONS: Bone marrow stem cell transplantation for myocardial regeneration can be safely performed in humans. There is evidence of improved revascularization and contractility of infarct areas, but controlled studies are needed to clearly determine the clinical benefit.
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Citations
Cited by
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Leri, A., Kajstura, J., & Anversa, P. (2005) · Physiological Reviews · doi:10.1152/physrev.00013.2005 · Cited by 451
Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Cartilage, and Adipose Tissue
Peng, L., Jia, Z., Yin, X., Zhang, X., Liu, Y., Chen, P., Ma, K., & Zhou, C. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0217 · Cited by 368
Majore, I., Moretti, P., Stahl, F., Hass, R., & Kasper, C. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9165-y · Cited by 167
Kuki, S., Imanishi, T., Kobayashi, K., Matsuo, Y., Obana, M., & Akasaka, T. (2006) · Circulation Journal · doi:10.1253/circj.70.1076 · Cited by 137
Metadata
- Authors
- Stamm, C., Kleine, H.-D., Westphal, B., Petzsch, M., Kittner, C., Nienaber, C. A., Freund, M., & Steinhoff, G.
- Venue
- The Thoracic and Cardiovascular Surgeon
- Publisher
- Georg Thieme Verlag KG
- Published
- 2004-06
- Volume
- 52
- Issue
- 3
- Pages
- 152-158
- ISSN
- 0171-6425 (ISSN-L)
- 1439-1902
- OpenAlex
- W2095434187
- Cited by
- 164
- References
- 0
- FWCI
- 14.24
- Type
- journal article
- Language
- de
- Open access
- closed
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- Stamm, C., Kleine, H.-D., Westphal, B., Petzsch, M., Kittner, C., Nienaber, C. A., Freund, M., & Steinhoff, G. (2004). CABG and Bone Marrow Stem Cell Transplantation after Myocardial Infarction. The Thoracic and Cardiovascular Surgeon. https://doi.org/10.1055/s-2004-817981
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