Human mesenchymal stem cells modulate allogeneic immune cell responses
Open accessAbstract
Mesenchymal stem cells (MSCs) are multipotent cells found in several adult tissues. Transplanted allogeneic MSCs can be detected in recipients at extended time points, indicating a lack of immune recognition and clearance. As well, a role for bone marrow-derived MSCs in reducing the incidence and severity of graft-versus-host disease (GVHD) during allogeneic transplantation has recently been reported; however, the mechanisms remain to be investigated. We examined the immunomodulatory functions of human MSCs (hMSCs) by coculturing them with purified subpopulations of immune cells and report here that hMSCs altered the cytokine secretion profile of dendritic cells (DCs), naive and effector T cells (T helper 1 [TH1] and TH2), and natural killer (NK) cells to induce a more anti-inflammatory or tolerant phenotype. Specifically, the hMSCs caused mature DCs type 1 (DC1) to decrease tumor necrosis factor α (TNF-α) secretion and mature DC2 to increase interleukin-10 (IL-10) secretion; hMSCs caused TH1 cells to decrease interferon γ (IFN-γ) and caused the TH2 cells to increase secretion of IL-4; hMSCs caused an increase in the proportion of regulatory T cells (TRegs) present; and hMSCs decreased secretion of IFN-γ from the NK cells. Mechanistically, the hMSCs produced elevated prostaglandin E2 (PGE2) in co-cultures, and inhibitors of PGE2 production mitigated hMSC-mediated immune modulation. These data offer insight into the interactions between allogeneic MSCs and immune cells and provide mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation. (Blood. 2005;105:1815-1822)
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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
Self-citationCaplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,563 · see citing works
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226 · see citing works
Le Blanc, K., Rasmusson, I., Sundberg, B., Götherström, C., Hassan, M., Uzunel, M., & Ringdén, O. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16104-7 · Cited by 2,734 · see citing works
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,726 · see citing works
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234 · see citing works
Self-citationCD4+CD25+ suppressor T cells: more questions than answers
Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097 · see citing works
Horwitz, E. M., Gordon, P. L., Koo, W. K. K., Marx, J. C., Neel, M. D., McNall, R. Y., Muul, L., & Hofmann, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132252399 · Cited by 1,650 · see citing works
Kopen, G. C., Prockop, D. J., & Phinney, D. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10711 · Cited by 1,643 · see citing works
Meisel, R., Zibert, A., Laryea, M. D., Göbel, U., Däubener, W., & Dilloo, D. (2004) · Blood · doi:10.1182/blood-2003-11-3909 · Cited by 1,638 · see citing works
Blanc, K. L., Tammik, C., Rosendahl, K., Zetterberg, E., & Ringdén, O. T. H. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00110-3 · Cited by 1,624 · see citing works
Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage.
Wakitani, S., Goto, T., Pineda, S. J., Young, R. G., Mansour, J. M., Caplan, A. I., & Goldberg, V. M. (1994) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199404000-00013 · Cited by 1,604 · see citing works
Tse, W. T., Pendleton, J. D., Beyer, W., Egalka, M. C., & Guinan, E. C. (2003) · Transplantation · doi:10.1097/01.tp.0000045055.63901.a9 · Cited by 1,501 · see citing works
Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics
Pittenger, M. F., & Martin, B. J. (2004) · Circulation Research · doi:10.1161/01.res.0000135902.99383.6f · Cited by 1,434 · see citing works
Self-citationDzionek, A., Fuchs, A., Schmidt, P., Cremer, S., Zysk, M., Miltenyi, S., Buck, D., & Schmitz, J. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.11.6037 · Cited by 1,433 · see citing works
Deans, R., & Moseley, A. B. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00482-3 · Cited by 1,412 · see citing works
Blanc, K. L., Tammik, L., Sundberg, B., Haynesworth, S. E., & Ringdén, O. T. H. (2003) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2003.01176.x · Cited by 1,367 · see citing works
Characterization of cells with osteogenic potential from human marrow
Haynesworth, S. E., GOSHIMA, J., Goldberg, V., & Caplan, A. I. (1992) · Bone · doi:10.1016/8756-3282(92)90364-3 · Cited by 1,291 · see citing works
Perin, E. C., Dohmann, H. F. R., Borojević, R., Silva, S. A., Sousa, A., Mesquita, C. T., Rossi, M. I. D., de Carvalho, A. C. C., Dutra, H. S., Dohmann, H. J. F., et al. (2003) · Circulation · doi:10.1161/01.cir.0000070596.30552.8b · Cited by 1,288 · see citing works
Liechty, K. W., MacKenzie, T. C., Shaaban, A. F., Radu, A. P., Moseley, A. B., Deans, R., Marshak, D. R., & Flake, A. W. (2000) · Nature Medicine · doi:10.1038/81395 · Cited by 1,217 · see citing works
Stromal Stem Cells: Marrow‐Derived Osteogenic Precursors
Owen, M. E., & Friedenstein, A. J. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513637.ch4 · Cited by 1,196 · see citing works
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168 · see citing works
Koç, O. N., Gerson, S. L., Cooper, B., Dyhouse, S. M., Haynesworth, S. E., Caplan, A. I., & Lazarus, H. M. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.2.307 · Cited by 1,119 · see citing works
Stem cell therapy in a caprine model of osteoarthritis
Murphy, M. J., Fink, D. J., Hunziker, E. B., & Barry, F. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11365 · Cited by 1,103 · see citing works
Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5‐azacytidine
Wakitani, S., Saito, T., & Caplan, A. I. (1995) · Muscle & Nerve · doi:10.1002/mus.880181212 · Cited by 1,081 · see citing works
Muraglia, A., Cancedda, R., & Quarto, R. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.7.1161 · Cited by 1,025 · see citing works
Autologous Transplantation of Bone Marrow Cells Improves Damaged Heart Function
Tomita, S., Li, R., Weisel, R. D., Mickle, D. A. G., Kim, E. J., Sakai, T., & Jia, Z.-Q. (1999) · Circulation · doi:10.1161/01.cir.100.suppl_2.ii-247 · Cited by 1,009 · see citing works
Shake, J. G., Gruber, P. J., Baumgartner, W. A., Sénéchal, G., Meyers, J., Redmond, J. M., Pittenger, M. F., & Martin, B. J. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)03517-8 · Cited by 901 · see citing works
Self-citationBone regeneration by implantation of purified, culture‐expanded human mesenchymal stem cells
Bruder, S. P., Kurth, A. A., Shea, M., Hayes, W. C., Jaiswal, N., & Kadiyala, S. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160202 · Cited by 761 · see citing works
Lazarus, H. M., Haynesworth, S. E., Gerson, S. L., Rosenthal, N. S., & Caplan, A. I. (1995) · PubMed · Cited by 749 · see citing works
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
Tilley, S. L., Coffman, T. M., & Koller, B. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113416 · Cited by 728 · see citing works
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
Tilley, S. L., Coffman, T. M., & Koller, B. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13416 · Cited by 725 · see citing works
Haynesworth, S. E., Baber, M. A., & Caplan, A. I. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199603)166:3 · Cited by 658 · see citing works
Koç, O., Day, J., Nieder, M. L., Gerson, S. L., Lazarus, H. M., & Krivit, W. A. (2002) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703650 · Cited by 649 · see citing works
Kawada, H., Fujita, J., Kinjo, K., Matsuzaki, Y., Tsuma, M., Miyatake, H., Muguruma, Y., Tsuboi, K., Itabashi, Y., Ikeda, Y., et al. (2004) · Blood · doi:10.1182/blood-2004-04-1488 · Cited by 566 · see citing works
Britten, M. B., Abolmaali, N., Aßmus, B., Lehmann, R., Honold, J., Schmitt, J., Vogl, T. J., Martin, H., Schächinger, V., Dimmeler, S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000095788.78169.af · Cited by 553 · see citing works
Pereira, R. F., O’Hara, M. D., Laptev, A. V., Halford, K. W., Pollard, M. D., Class, R., Simón, D., Livezey, K., & Prockop, D. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1142 · Cited by 544 · see citing works
Characterization and Functionality of Cell Surface Molecules on Human Mesenchymal Stem Cells
Majumdar, M. K., Keane-Moore, M., Buyaner, D., Hardy, W., Moorman, M. A., McIntosh, K. R., & Mosca, J. D. (2003) · Journal of Biomedical Science · doi:10.1007/bf02256058 · Cited by 527 · see citing works
ALLOGENEIC MESENCHYMAL STEM CELLS REGENERATE BONE IN A CRITICAL-SIZED CANINE SEGMENTAL DEFECT
Arinzeh, T. L., Peter, S. J., Archambault, M., van den Bos, C., GORDON, S., Kraus, K. H., SMITH, A., & Kadiyala, S. (2003) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200310000-00010 · Cited by 503 · see citing works
Zhang, W., Ge, W., Li, C., You, S., Liao, L., Han, Q., Deng, W., & Zhao, R. C. H. (2004) · Stem Cells and Development · doi:10.1089/154732804323099190 · Cited by 492 · see citing works
Majumdar, M. K., Thiede, M. A., Haynesworth, S. E., Bruder, S. P., & Gerson, S. L. (2000) · Stem Cells and Development · doi:10.1089/152581600750062264 · Cited by 455 · see citing works
Potian, J. A., Aviv, H., Ponzio, N. M., Harrison, J. S., & Rameshwar, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3426 · Cited by 426 · see citing works
Repair of patellar tendon injuries using a cell–collagen composite
Awad, H. A., Boivin, G. P., Dressler, M. R., Smith, F. N. L., Young, R. G., & Butler, D. L. (2003) · Journal of Orthopaedic Research® · doi:10.1016/s0736-0266(02)00163-8 · Cited by 395 · see citing works
Human Adult Marrow Cells Support Prolonged Expansion of Human Embryonic Stem Cells in Culture
Cheng, L., Hammond, H., Ye, Z., Zhan, X., & Dravid, G. G. (2003) · Stem Cells · doi:10.1634/stemcells.21-2-131 · Cited by 331 · see citing works
Blanc, K. L., Rasmusson, I., Gotherstrom, C. O. T., Seidel, C. D., Sundberg, B., Sundin, M., Rosendahl, K., Tammik, C., & Ringdén, O. T. H. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01483.x · Cited by 330 · see citing works
Grinnemo, K., Månsson‐Broberg, A., Dellgren, G., Klingberg, D., Wärdell, E., Drvota, V., Tammik, C., Holgersson, J., Ringdén, O. T. H., Sylvén, C., et al. (2004) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2003.07.037 · Cited by 294 · see citing works
Lennon, D. P., Haynesworth, S. E., Bruder, S. P., Jaiswal, N., & Caplan, A. I. (1996) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02724045 · Cited by 284 · see citing works
Gao, J., Dennis, J. E., Solchaga, L. A., Awadallah, A., Goldberg, V. M., & Caplan, A. I. (2001) · Tissue Engineering · doi:10.1089/10763270152436427 · Cited by 283 · see citing works
Urist, M. R., & McLean, F. C. (1952) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-195234020-00015 · Cited by 265 · see citing works
Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells
Gotherstrom, C. O. T., Ringdén, O. T. H., Westgren, M., Tammik, C., & Blanc, K. L. (2003) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704111 · Cited by 203 · see citing works
Dendritic cell subsets and the regulation of Th1/Th2 responses
Maldonado-López, R., & Moser, M. (2001) · Seminars in Immunology · doi:10.1006/smim.2001.0323 · Cited by 194 · see citing works
Migration of mesenchymal stem cells to heart allografts during chronic rejection
Wu, G. D., Nolta, J. A., Jin, Y.-S., Barr, M. L., Yu, H., Starnes, V. A., & Cramer, D. V. (2003) · Transplantation · doi:10.1097/01.tp.0000048488.35010.95 · Cited by 173 · see citing works
Cytolytic pathways in haematopoietic stem-cell transplantation
van den Brink, M. R. M., & Burakoff, S. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri775 · Cited by 170 · see citing works
CABG and Bone Marrow Stem Cell Transplantation after Myocardial Infarction
Stamm, C., Kleine, H.-D., Westphal, B., Petzsch, M., Kittner, C., Nienaber, C. A., Freund, M., & Steinhoff, G. (2004) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-2004-817981 · Cited by 164 · see citing works
MacKenzie, T. C., & Flake, A. W. (2001) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2001.0424 · Cited by 157 · see citing works
Regenerative medicine through mesenchymal stem cells for bone and cartilage repair.
Noël, D., Djouad, F., & Jorgense, C. (2002) · PubMed · Cited by 155 · see citing works
Kok, I. J. D., Peter, S. J., Archambault, M., van den Bos, C., Kadiyala, S., Aukhil, L., & Cooper, L. F. (2003) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.2003.110770.x · Cited by 145 · see citing works
Cheng, L., Qasba, P., Vanguri, P., & Thiede, M. A. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 136 · see citing works
Newberry, R. D., McDonough, J. S., Stenson, W. F., & Lorenz, R. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4465 · Cited by 110 · see citing works
Mobilization and homing of bone marrow stromal cells in myocardial infarction
Bittira, B. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00325-7 · Cited by 109 · see citing works
Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes
Obermaier, B., Dauer, M., Herten, J., Schad, K., Endres, S., & Eigler, A. (2003) · Biological Procedures Online · doi:10.1251/bpo62 · Cited by 85 · see citing works
Ritter, U., Meißner, A., Ott, J., & Körner, H. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.1202587 · Cited by 77 · see citing works
Abe, K., Yarovinsky, F., Murakami, T., Shakhov, A. N., Tumanov, A. V., Ito, D., Drutskaya, L. N., Pfeffer, K., Kuprash, D. V., Komschlies, K. L., et al. (2003) · Blood · doi:10.1182/blood.v101.4.1477 · Cited by 74 · see citing works
Elfenbein, G. J., & Sackstein, R. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.01.010 · Cited by 71 · see citing works
Mahmud, N., Pang, W., Cobbs, C., Alur, P. R. K., Borneman, J. N., Dodds, R. A., Archambault, M., Devine, S. M., Turian, J. V., Bartholomew, A. M., et al. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.02.010 · Cited by 58 · see citing works
Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
Keller, J. N., & Markesbery, W. R. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 54 · see citing works
Monoclonal antibodies for the prevention and treatment of graft-versus-host disease
Bruner, R. J., & Farag, S. S. (2003) · Seminars in Oncology · doi:10.1016/s0093-7754(03)00250-1 · Cited by 40 · see citing works
TNF-α targeted therapeutic approaches in patients with hematologic malignancies
Tsimberidou, A. M., & Giles, F. J. (2002) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2.3.277 · Cited by 35 · see citing works
Suppression of graft-versus-host disease by naturally occurring regulatory T cells.
Zeng, D., Lan, F., Hoffmann, P., & Strober, S. (2004) · Transplantation · doi:10.1097/01.tp.0000106475.38978.11 · Cited by 26 · see citing works
Natural regulatory CD4 T cells expressing CD25
Papiernik, M., & Banz, A. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01455-1 · Cited by 16 · see citing works
Slavin, S. (2003) · International Journal of Hematology · doi:10.1007/bf02983795 · Cited by 14 · see citing works
Current concepts in allogeneic hematopoietic stem cell transplantation.
Tabbara, I. A., Kairouz, S. S., Nahleh, Z. A., & Mihalcea, A. M. (2003) · PubMed · Cited by 11 · see citing works
Cloning and Characterization of a Potential Transcriptional Activator of Human γ-Globin Genes
Yang, Y., Duan, Z., Skarpidi, E., Li, Q., Papayannopoulou, T., & Stamatoyannopoulos, G. (2001) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2000.0344 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [9]9. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 2000; 61:364-370.
- [24]24. De Kok IJ, Peter SJ, Archambault M, et al. Inves- tigation of allogeneic mesenchymal stem cell- based alveolar bone formation: preliminary find- ings. Clin Oral Implants Res. 2003;14:481-489.
- [45]45. Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000;28:875-884.
- [50]50. Archambault MP, McIntosh KR, Duty A, Peter SJ. Allogeneic rat mesenchymal stem cells do not elicit an immune response after implantation in immunocompetent recipients [abstract]. Blood. 2000;96:762a. Abstract 3295.
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Uccelli, A., Moretta, L., & Pistoia, V. (2008) · Nature reviews. Immunology · doi:10.1038/nri2395 · Cited by 3,750 · see citing works
The extracellular matrix: A dynamic niche in cancer progression
Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024 · see citing works
Blanc, K. L., Frassoni, F., Ball, L. M., Locatelli, F., Roelofs, H., Lewis, I., Lanino, E., Sundberg, B., Bernardo, M. E., Remberger, M., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60690-x · Cited by 2,692 · see citing works
Chamberlain, G., Fox, J. M., Ashton, B. A., & Middleton, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0197 · Cited by 2,376 · see citing works
Németh, K., Leelahavanichkul, A., Yuen, P. S. T., Mayer, B., Parmelee, A., Doi, K., Robey, P. G., Leelahavanichkul, K., Koller, B. H., Brown, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1905 · Cited by 2,364 · see citing works
Ren, G., Zhang, L., Zhao, X., Xu, G., Zhang, Y., Roberts, A. I., Zhao, R. C., & Shi, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.11.014 · Cited by 2,101 · see citing works
Mesenchymal stem cell perspective: cell biology to clinical progress
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0083-6 · Cited by 2,008 · see citing works
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Caplan, A. I. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21200 · Cited by 1,956 · see citing works
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Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834 · see citing works
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Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767 · see citing works
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Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy
Zappia, E., Casazza, S., Pedemonte, E., Benvenuto, F., Bonanni, I., Gerdoni, E., Giunti, D., Ceravolo, A., Cazzanti, F., Frassoni, F., et al. (2005) · Blood · doi:10.1182/blood-2005-04-1496 · Cited by 1,431 · see citing works
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Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., & Wang, Y. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0023-5 · Cited by 1,223 · see citing works
Tögel, F., Hu, Z.-M., Weiss, K., Isaac, J., Lange, C., & Westenfelder, C. (2005) · AJP - Renal Physiology · doi:10.1152/ajprenal.00007.2005 · Cited by 1,196 · see citing works
Spaggiari, G. M., Capobianco, A., Abdelrazik, H., Becchetti, F., Mingari, M. C., & Moretta, L. (2007) · Blood · doi:10.1182/blood-2007-02-074997 · Cited by 1,139 · see citing works
Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease
Ringdén, O. T. H., Uzunel, M., Rasmusson, I., Remberger, M., Sundberg, B., Lönnies, H., Marschall, H., Dlugosz, A., Szakos, A., Hassan, Z., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000214462.63943.14 · Cited by 1,143 · see citing works
Waterman, R. S., Tomchuck, S. L., Henkle, S. L., & Betancourt, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010088 · Cited by 1,238 · see citing works
Mesenchymal Stem Cells for Regenerative Medicine
Han, Y., Li, X., Zhang, Y., Han, Y., Chang, F., & Ding, J. (2019) · Cells · doi:10.3390/cells8080886 · Cited by 1,093 · see citing works
Selmani, Z., Naji, A., Zidi, I., Favier, B., Gaiffe, É., Obert, L., Borg, C., Saas, P., Tiberghien, P., Rouas‐Freiss, N., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0554 · Cited by 1,078 · see citing works
Spaggiari, G. M., Capobianco, A., Becchetti, S., Mingari, M. C., & Moretta, L. (2005) · Blood · doi:10.1182/blood-2005-07-2775 · Cited by 1,057 · see citing works
Multipotent mesenchymal stromal cells and the innate immune system
Blanc, K. L., & Mougiakakos, D. (2012) · Nature reviews. Immunology · doi:10.1038/nri3209 · Cited by 1,019 · see citing works
Puissant‐Lubrano, B., Barreau, C., Bourin, P., Clavel, C., Corre, J., Bousquet, C., Taureau, C., Cousin, B., Abbal, M., Laharrague, P. F., et al. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05409.x · Cited by 957 · see citing works
Interactions Between Human Mesenchymal Stem Cells and Natural Killer Cells
Sotiropoulou, P. A., Perez, S. A., Gritzapis, A. D., Baxevanis, C. N., & Papamichail, M. (2006) · Stem Cells · doi:10.1634/stemcells.2004-0359 · Cited by 956 · see citing works
Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
Sato, K., Ozaki, K., Oh, I., Meguro, A., Hatanaka, K., Nagai, T., Muroi, K., & Ozawa, K. (2006) · Blood · doi:10.1182/blood-2006-02-002246 · Cited by 952 · see citing works
Mesenchymal stem cells: a new trend for cell therapy
Wei, X., Yang, X. F., Han, Z., Qu, F.-F., Shao, L., & Shi, Y. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.50 · Cited by 945 · see citing works
Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis
Lin, Y., Anzaghe, M., & Schülke, S. (2020) · Cells · doi:10.3390/cells9040880 · Cited by 967 · see citing works
Gupta, N., Su, X., Popov, B. V., Lee, J. W., Serikov, V. B., & Matthay, M. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1855 · Cited by 931 · see citing works
Mesenchymal Stromal Cells: Current Understanding and Clinical Status
Salem, H. K., & Thiemermann, C. (2009) · Stem Cells · doi:10.1002/stem.269 · Cited by 915 · see citing works
Ding, D., Shyu, W., & Lin, S. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 915 · see citing works
Mesenchymal stem cells avoid allogeneic rejection
Ryan, J. M., Barry, F., Murphy, M. J., & Mahon, B. P. (2005) · Journal of Inflammation · doi:10.1186/1476-9255-2-8 · Cited by 912 · see citing works
Mechanisms of mesenchymal stem/stromal cell function
Spees, J. L., Lee, R. H., & Gregory, C. A. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0363-7 · Cited by 893 · see citing works
Williams, A. R., & Hare, J. M. (2011) · Circulation Research · doi:10.1161/circresaha.111.243147 · Cited by 889 · see citing works
Advances in graft-versus-host disease biology and therapy
Blazar, B. R., Murphy, W. J., & Abedi, M. (2012) · Nature reviews. Immunology · doi:10.1038/nri3212 · Cited by 880 · see citing works
In Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077 · see citing works
Stem Cell Paracrine Actions and Tissue Regeneration
Baraniak, P. R., & McDevitt, T. C. (2010) · Regenerative Medicine · doi:10.2217/rme.09.74 · Cited by 843 · see citing works
Mesenchymal Stem Cells: Mechanisms of Inflammation
Singer, N. G., & Caplan, A. I. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130230 · Cited by 852 · see citing works
Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works
Concise Review: Role of Mesenchymal Stem Cells in Wound Repair
Maxson, S., Lopez, E. A., Yoo, D. S., Danilkovitch‐Miagkova, A., & LeRoux, M. A. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0018 · Cited by 813 · see citing works
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
Ranganath, S. H., Levy, O., Inamdar, M. S., & Karp, J. M. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.005 · Cited by 808 · see citing works
Immunobiology of mesenchymal stem cells
Ma, S., Xie, N., Li, W., Yuan, B., Shi, Y., & Wang, Y. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.158 · Cited by 772 · see citing works
Mesenchymal Stem Cells as Therapeutics
Parekkadan, B., & Milwid, J. M. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105309 · Cited by 758 · see citing works
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747 · see citing works
Zhang, Q., Shi, S., Liu, Y., Uyanne, J., Shi, Y., Shi, S., & Le, A. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902318 · Cited by 753 · see citing works
Nauta, A. J., Kruisselbrink, A. B., Lurvink, E. G. A., Willemze, R., & Fibbe, W. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.4.2080 · Cited by 741 · see citing works
Samsonraj, R. M., Raghunath, M., Nurcombe, V., Hui, J. H. P., van Wijnen, A. J., & Cool, S. M. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0129 · Cited by 732 · see citing works
Mei, S. H. J., Haitsma, J. J., dos Santos, C. C., Deng, Y., Lai, P. F. H., Slutsky, A. S., Liles, W. C., & Stewart, D. J. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0010oc · Cited by 722 · see citing works
Immunomodulation by mesenchymal stem cells and clinical experience
Blanc, K. L., & Ringdén, O. T. H. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01844.x · Cited by 720 · see citing works
Yañez, R., Lamana, M. L., Garcı́a-Castro, J., Colmenero, I., Ramírez, M. R., & Bueren, J. A. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0228 · Cited by 719 · see citing works
Lee, J. W., Fang, X., Gupta, N., Serikov, V. B., & Matthay, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907996106 · Cited by 716 · see citing works
Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis
Akiyama, K., Chen, C., Wang, D., Xu, X., Qu, C., Yamaza, T., Cai, T., Chen, W., Sun, L., & Shi, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.03.007 · Cited by 707 · see citing works
Mesenchymal Stem Cells Secrete Immunologically Active Exosomes
Zhang, B., Yin, Y., Lai, R. C., Tan, S. S., Choo, A. B. H., & Lim, S. K. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0479 · Cited by 698 · see citing works
Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing
Yagi, H., Soto–Gutiérrez, A., Parekkadan, B., Kitagawa, Y., Tompkins, R. G., Kobayashi, N., & Yarmush, M. L. (2010) · Cell Transplantation · doi:10.3727/096368910x508762 · Cited by 699 · see citing works
Weiß, A. R. R., & Dahlke, M. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01191 · Cited by 695 · see citing works
Docheva, D., Müller, S., Majewski, M., & Evans, C. H. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.11.015 · Cited by 694 · see citing works
Nauta, A. J., Westerhuis, G., Kruisselbrink, A. B., Lurvink, E. G. A., Willemze, R., & Fibbe, W. E. (2006) · Blood · doi:10.1182/blood-2005-11-011650 · Cited by 694 · see citing works
Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis
González‐Rey, E., Anderson, P. O., González, M. A., Rico, L., Büscher, D., & Delgado, M. (2009) · Gut · doi:10.1136/gut.2008.168534 · Cited by 677 · see citing works
English, K., Ryan, J. M., Tobin, L., Murphy, M. J., Barry, F., & Mahon, B. P. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03874.x · Cited by 674 · see citing works
Spaggiari, G. M., Abdelrazik, H., Becchetti, F., & Moretta, L. (2009) · Blood · doi:10.1182/blood-2009-02-203943 · Cited by 670 · see citing works
Djouad, F., Charbonnier, L., Bouffi, C., Louis‐Plence, P., Bony, C., Apparailly, F., Cantos, C., Jørgensen, C., & Noël, D. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0548 · Cited by 666 · see citing works
Ren, G., Zhao, X., Zhang, L., Zhang, J., L'Huillier, A., Ling, W., Roberts, A. I., Le, A. D., Shi, S., Shao, C., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902023 · Cited by 655 · see citing works
Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation
Galleu, A., Riffo‐Vasquez, Y., Trento, C., Lomas, C., Dolcetti, L., Cheung, T. S., Bonin, M. V., Barbieri, L., Halai, K., Ward, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7828 · Cited by 647 · see citing works
Nussbaum, J., Minami, E., Laflamme, M. A., Virag, J. A. I., Ware, C. B., Masino, A. M., Muskheli, V., Pabon, L., Reinecke, H., & Murry, C. E. (2007) · The FASEB Journal · doi:10.1096/fj.06-6769com · Cited by 646 · see citing works
Togel, F. E., Weiss, K., Yang, Y., Hu, Z., Zhang, P., & Westenfelder, C. S. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00339.2006 · Cited by 642 · see citing works
How mesenchymal stem cells interact with tissue immune responses
Shi, Y., Su, J., Roberts, A. I., Shou, P., Rabson, A. B., & Ren, G. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.11.004 · Cited by 629 · see citing works
González, M. A., González‐Rey, E., Rico, L., Büscher, D., & Delgado, M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.11.041 · Cited by 631 · see citing works
Keating, A. (2006) · Current Opinion in Hematology · doi:10.1097/01.moh.0000245697.54887.6f · Cited by 626 · see citing works
Biological functions of mesenchymal stem cells and clinical implications
Naji, A., Eitoku, M., Favier, B., Deschaseaux, F., Rouas‐Freiss, N., & Suganuma, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03125-1 · Cited by 628 · see citing works
Duijvestein, M., Vos, A. C. W., Roelofs, H., Wildenberg, M. E., Wendrich, B. B., Verspaget, H. W., Kooy-Winkelaar, E. M. C., Koning, F., Zwaginga, J. J., Fidder, H. H., et al. (2010) · Gut · doi:10.1136/gut.2010.215152 · Cited by 622 · see citing works
Zhang, Q.-Z., Su, W., Shi, S., Wilder-Smith, P. B. B., Xiang, A. P., Wong, A. K., Nguyen, A. L., Kwon, C. W., & Le, A. D. (2010) · Stem Cells · doi:10.1002/stem.503 · Cited by 620 · see citing works
Mei, S. H. J., McCarter, S. D., Deng, Y., Parker, C. H., Liles, W. C., & Stewart, D. J. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040269 · Cited by 618 · see citing works
Secretion of immunoregulatory cytokines by mesenchymal stem cells
Kyurkchiev, D. S. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i5.552 · Cited by 619 · see citing works
Concise Review: Mesenchymal Stem Cells: From Roots to Boost
Andrzejewska, A., Łukomska, B., & Janowski, M. (2019) · Stem Cells · doi:10.1002/stem.3016 · Cited by 610 · see citing works
Celiac Disease: From Pathogenesis to Novel Therapies
Schuppan, D., Junker, Y., & Barisani, D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.008 · Cited by 609 · see citing works
Fabrication of Scaffolds for Bone-Tissue Regeneration
Chocholata, P. K., Kulda, V., & Babuška, V. (2019) · Materials · doi:10.3390/ma12040568 · Cited by 607 · see citing works
Deciphering and Reversing Tumor Immune Suppression
Motz, G. T., & Coukos, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.005 · Cited by 600 · see citing works
Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression
Ren, G., Su, J., Zhang, L., Zhao, X., Ling, W., L'huillie, A., Zhang, J., Lu, Y., Roberts, A. I., Ji, W., et al. (2009) · Stem Cells · doi:10.1002/stem.118 · Cited by 597 · see citing works
Ghannam, S., Pène, J., Moquet-Torcy, G., Jørgensen, C., & Yssel, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902007 · Cited by 597 · see citing works
Ryan, J. M., Barry, F., Murphy, M. J., & Mahon, B. P. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03422.x · Cited by 596 · see citing works
Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
Ferreira, J. R., Teixeira, G. Q., Santos, S. G., Barbosa, M. A., Almeida-Porada, G., & Gonçalves, R. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02837 · Cited by 572 · see citing works
Immune modulation by mesenchymal stem cells
Jiang, W., & Xu, J. (2020) · Cell Proliferation · doi:10.1111/cpr.12712 · Cited by 650 · see citing works
Quevedo, H. C., Hatzistergos, K. E., Oskouei, B. N., Feigenbaum, G. S., Rodríguez, J. E., Valdes, D., Pattany, P. M., Zambrano, J. P., Hu, Q., McNiece, I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903201106 · Cited by 586 · see citing works
Sun, L., Akiyama, K., Zhang, H., Yamaza, T., Hou, Y., Zhao, S., Xu, T., Lê, A., & Shi, S. (2009) · Stem Cells · doi:10.1002/stem.68 · Cited by 581 · see citing works
IFN‐γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease
Polchert, D., Sobinsky, J., Douglas, G., Kidd, M. E., Moadsiri, A., Reina, E., Genrich, K., Mehrotra, S., Setty, S., Smith, B., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200738129 · Cited by 580 · see citing works
Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair
Shi, Y., Hu, G., Su, J., Li, W., Chen, Q., Shou, P., Xu, C., Chen, X., Huang, Y., Zhu, Z., et al. (2010) · Cell Research · doi:10.1038/cr.2010.44 · Cited by 575 · see citing works
Mesenchymal stem cell exosomes
Lai, R. C., Yeo, R. W. Y., & Lim, S. K. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.03.001 · Cited by 573 · see citing works
Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells
Vega, A., Martín-Ferrero, M. Á., Canto, F. D., Alberca, M., García, V., Munar, A., Orozco, L., Soler, R., Fuertes, J. J., Huguet, M., et al. (2015) · Transplantation · doi:10.1097/tp.0000000000000678 · Cited by 573 · see citing works
The Immunogenicity of Human Adipose‐Derived Cells: Temporal Changes In Vitro
McIntosh, K. R., Zvonic, S., Garrett, S. M., Mitchell, J. B., Floyd, Z. E., Hammill, L., Kloster, A. L., Halvorsen, Y. D. C., Ting, J. P. ‐., Storms, R. W., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0235 · Cited by 570 · see citing works
Immunoregulatory function of mesenchymal stem cells
Uccelli, A., Moretta, L., & Pistoia, V. (2006) · European Journal of Immunology · doi:10.1002/eji.200636416 · Cited by 558 · see citing works
Exosomes for drug delivery—A novel application for the mesenchymal stem cell
Lai, R. C., Yeo, R. W. Y., Tan, K. H., & Lim, S. K. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.08.008 · Cited by 546 · see citing works
Bai, L., Lennon, D. P., Eaton, V. L., Maier, K., Caplan, A. I., Miller, S. D., & Miller, R. H. (2009) · Glia · doi:10.1002/glia.20841 · Cited by 539 · see citing works
Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy
Baglio, S. R., Pegtel, D. M., & Baldini, N. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00359 · Cited by 543 · see citing works
Ries, C., Egea, V., Karow, M., Kolb, H. J., Jochum, M., & Neth, P. (2006) · Blood · doi:10.1182/blood-2006-10-051060 · Cited by 539 · see citing works
The Pros and Cons of Mesenchymal Stem Cell-Based Therapies
Musiał-Wysocka, A., Kot, M., & Majka, M. (2019) · Cell Transplantation · doi:10.1177/0963689719837897 · Cited by 538 · see citing works
Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy
Fan, X., Zhang, Y., Li, X., & Fu, Q. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03454-6 · Cited by 539 · see citing works
- Authors
- Aggarwal, S., & Pittenger, M. F.
- Affiliations
- Osiris Therapeutics (United States) (US)
- ORCID
- Pittenger, Mark F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-02-15
- Volume
- 105
- Issue
- 4
- Pages
- 1815-1822
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2095666785
- Cited by
- 4,511
- References
- 73
- Citations by year
- 2026: 51 · 2025: 82 · 2024: 118 · 2023: 158 · 2022: 187 · 2021: 253 · 2020: 236 · 2019: 209 · 2018: 233 · 2017: 251 · 2016: 312 · 2015: 284 · 2014: 299 · 2013: 338 · 2012: 328
- FWCI
- 47.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Osiris Therapeutics
- Defense Advanced Research Projects Agency
- Advanced Research Projects Agency
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- mesenchymal stem cells, immunomodulation, graft-versus-host disease, allogeneic transplantation, dendritic cells, T helper cells, natural killer cells, regulatory T cells, prostaglandin E2, cytokine production, immune tolerance, bone marrow-derived stem cells
- MeSH terms
- Cell Communication, Cells, Cultured, Dendritic Cells, Humans, Immunologic Factors, Immunosuppression Therapy, Killer Cells, Natural, Leukocytes, Mononuclear, Lymphocyte Activation, Mesoderm, T-Lymphocytes, Transplantation, Homologous, Dinoprostone, Coculture Techniques, Multipotent Stem Cells
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