Bioactive Diels-Alder Type Adducts from the Stem Bark of Morus macroura
Abstract
Five new compounds, named guangsangons A (1), B (5), C (6), D (7), and E (8), along with four known compounds, albafuran C (2), kuwanon X (3), kuwanon P (4), and kuwanon Y (9) were isolated from Morus macroura Miq.. Their structures were determined by means of spectroscopic analyses and chemical methods. These compounds were regarded biogenetically as Diels-Al-der type adducts, and 1H-NMR variable temperature experience suggested that they all existed as an equilibrium mixture of conformational isomers in solution. Compounds 1-3 and 5-9 showed good anti-oxidation activity, with the inhibitory rate of malondialdehyde being from 90.1% to 102.7% at a concentration of 10(-4) mol/L and from 70.9% to 88.1% at a concentration of 10(-5) mol/L. Compounds 1, 5, and 7 showed anti-inflammation activity, with the inhibitory rates of release of lysosome enzyme from polymorphonuclear leukocytes of rats being 19.0% (P > 0.05), 57.3% (P < 0.001) and 24.3% (P < 0.05) at concentrations of 10(-5) mol/L, respectively.
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Compounds I-III showed significant anti-inflammatory activities with IC50-values ranging from 1.51 to 11.68 μM in the β-glucuronidase release assay in rat PMNs induced by platelet-activating factor.
“Compounds I–III showed significant anti-inflammatory activities with IC50-values ranging from 1.51 to 11.68 μM, respectively.”
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Self-citation
- Authors
- Dai, S.-J., Mi, Z.-M., Ma, Z.-B., Li, S., Chen, R.-Y., & Yu, D.-Q.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2004-08
- Volume
- 70
- Issue
- 8
- Pages
- 758-763
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1976730658
- Cited by
- 38
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Medical Sciences
- Chinese Academy of Medical Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Keywords
- Morus macroura, stem bark, natural product isolation, structure elucidation, conformational isomerism, antioxidant activity, anti-inflammatory activity, lysosomal enzyme release, polymorphonuclear leukocytes
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Glucuronidase, Malondialdehyde, Phytotherapy, Neutrophils, Plant Extracts, Plant Bark, Morus, Rats
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