Identification of Tyrosinase Inhibitors from Glycyrrhiza uralensis
Abstract
Tyrosinase is a key enzyme in the production of melanins. Phytochemical studies of a Glycyrrhiza uralensis extract were performed by measuring the tyrosinase and melanin synthesis inhibitory activity. Glycyrrhisoflavone and glyasperin C were identified as tyrosinase inhibitors for the first time. Glyasperin C showed a stronger tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL) than glabridin (IC (50) = 0.25 +/- 0.01 microg/mL) and a moderate inhibition of melanin production (17.65 +/- 8.8 % at 5 microg/mL). Glycyrrhisoflavone showed a strong melanin synthesis inhibitory activity (63.73 +/- 6.8 % inhibition at 5 microg/mL). These results suggest that glyasperin C and glycyrrhisoflavone could be promising candidates in the design of skin-whitening agents.
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Glycyrrhisoflavone, kaempferol, glyasperin C, and glyasperin D have skin-whitening properties.
“In addition to the extracts, the skin-whitening properties were also reported for the bioactive compounds glycyrrhisoflavone, kaempferol, glyasperin C, and glyasperin D [52,53].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [52]
Bioactive compounds glycyrrhisoflavone, kaempferol, glyasperin C, and glyasperin D have skin-whitening properties.
“In addition to the extracts, the skin-whitening properties were also reported for the bioactive compounds glycyrrhisoflavone, kaempferol, glyasperin C, and glyasperin D [52,53].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [52]
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Sorted by citations
Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
- Authors
- Kim, H., Seo, S., Lee, B.-G., & Lee, Y.
- Affiliations
- Korean Association Of Science and Technology Studies (KR)
- Amorepacific (South Korea) (KR)
- Kyung Hee University (KR)
- ORCID
- Lee, Yong
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2005-08
- Volume
- 71
- Issue
- 08
- Pages
- 785-787
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2045137259
- Cited by
- 53
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2013: 3 · 2012: 3
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- tyrosinase inhibitors, Glycyrrhiza uralensis, melanogenesis inhibition, glabridin, skin whitening products, phytochemical screening
- MeSH terms
- Enzyme Inhibitors, Humans, Phytotherapy, Melanins, Plant Extracts, Monophenol Monooxygenase, Plant Roots, Inhibitory Concentration 50, Glycyrrhiza uralensis
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