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Hypotensive Constituents from the Pods of Moringa oleifera
Abstract
Hypotensive activity of the ethanolic and aqueous extracts of Moringa oleifera whole pods and their parts, namely, coat, pulp, and seed was investigated. The activity of the ethanolic extract of both the pods and the seeds was equivalent at the dose of 30 mg/kg. The ethyl acetate phase of the ethanolic extract of pods was found to be the most potent fraction at the same dose. Its bioassay-directed fractionation led to the isolation of thiocarbamate and isothiocyanate glycosides which were also the hypotensive principles of the pods as observed in case of Moringa leaves. Two new compounds, O-[2'-hydroxy-3'-(2"-heptenyloxy)]-propyl undecanoate (1) and O-ethyl-4-[(alpha-L-rhamnosyloxy)-benzyl] carbamate (2) along with the known substances methyl p-hydroxybenzoate (3) and beta-sitosterol have also been isolated in the present studies. The latter two compounds and p-hydroxybenzaldehyde showed promising hypotensive activity. Structures of all these compounds have been deduced by spectroscopy and chemical reactions.
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Cited by
Moringa oleifera : a food plant with multiple medicinal uses
Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007) · Phytotherapy Research · doi:10.1002/ptr.2023 · Cited by 1,657
Self-citationIn vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves
Verma, A. R., Vijayakumar, M., Mathela, C. S., & Rao, C. V. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.06.005 · Cited by 498
Mehta, K., Balaraman, R., Amin, A. H., Bafna, P. A., & Gulati, O. D. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00075-8 · Cited by 324
Ma, Z. F., Ahmad, J., Zhang, H., Khan, I., & Muhammad, S. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2018.12.002 · Cited by 257
Vázquez-León, L. A., Páramo-Calderón, D. E., Robles-Olvera, V. J., Valdés-Rodríguez, O. A., Pérez-Vázquez, A., García-Alvarado, M. A., & Rodríguez-Jimenes, G. C. (2017) · European Food Research and Technology · doi:10.1007/s00217-017-2868-4 · Cited by 86
Metadata
- Authors
- Faizi, S., Siddiqui, B., Saleem, R., Aftab, K., Shaheen, F., & Gilani, A.-U.-H.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1998-04
- Volume
- 64
- Issue
- 03
- Pages
- 225-228
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1999356728
- Cited by
- 170
- References
- 0
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Faizi, S., Siddiqui, B., Saleem, R., Aftab, K., Shaheen, F., & Gilani, A.-U.-H. (1998). Hypotensive Constituents from the Pods of Moringa oleifera. Planta Medica. https://doi.org/10.1055/s-2006-957414
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