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Cytotoxic Terpenoids and Flavonoids from Artemisia annua
Abstract
The cytotoxic activity of nine terpenoids and flavonoids isolated from Artemisia annua was tested in vitro on several human tumor cell lines. These compounds are artemisinin, deoxyartemisinin, artemisinic acid, arteannuin-B, stigmasterol, friedelin, friedelan-3 beta-ol, artemetin, and quercetagetin 6,7,3',4'-tetramethyl ether. Friedelane-type triterpenoids were isolated for the first time from this plant. Artemisinin and quercetagetin 6,7,3',4'-tetramethyl ether showed significant cytotoxicity against P-388, A-549, HT-29, MCF-7, and KB tumor cells.
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“Artemisinic acid (473) [105,147,148], arteannuin B (462) [105,147,149] and artemisinin (495) [105,147,150] are the most abundant representatives of this class of natural products”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [105]
In the citing paper
“and were amongst the first sesquiterpenes to be reported from A. annua.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [105]
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Items 101–139 of 139
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“Our work demonstrated the relatively low cytotoxicity of ArA in BMMs in vitro , which supports the conclusions of Zheng concerning the relative cytotoxicity of ArA in other cell lines (Zheng, 1994).”
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“, 1993), anticancer (Zheng, 1994), antifungal (Liu et al.”
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“Some of them are artemisinin, deoxy-artemisinin, artemisinic acid, arteannuin B, stigmasterol, friedelin and artemetin [11].”
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“It has been well established that STLs and flavones exhibit remarkable biological effects, including antimalarial (3-5), cytotoxic (6), antibacterial (7), antifungal, and antioxidant (8) activities.”
Sample Preparation and Purification
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Metadata
- Authors
- Zheng, G.-Q.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-02
- Volume
- 60
- Issue
- 01
- Pages
- 54-57
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2094117413
- Cited by
- 139
- References
- 0
- Citations by year
- 2025: 2 · 2024: 8 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 1 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 4 · 2012: 5
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r43ca056262-01a1)
- National Cancer Institute (CA 56262)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Keywords
- Artemisia annua, cytotoxicity, terpenoids, flavonoids, artemisinin, artemisinic acid, arteannuin B, stigmasterol, friedelin, artemetin, quercetagetin, anticancer activity, human cancer cell lines
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Drugs, Chinese Herbal, Flavonoids, Humans, Leukemia P388, Terpenes, Tumor Cells, Cultured, Molecular Structure, Mice
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