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Cytotoxic Terpenoids and Flavonoids from Artemisia annua
Abstract
The cytotoxic activity of nine terpenoids and flavonoids isolated from Artemisia annua was tested in vitro on several human tumor cell lines. These compounds are artemisinin, deoxyartemisinin, artemisinic acid, arteannuin-B, stigmasterol, friedelin, friedelan-3 beta-ol, artemetin, and quercetagetin 6,7,3',4'-tetramethyl ether. Friedelane-type triterpenoids were isolated for the first time from this plant. Artemisinin and quercetagetin 6,7,3',4'-tetramethyl ether showed significant cytotoxicity against P-388, A-549, HT-29, MCF-7, and KB tumor cells.
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“Artemisinic acid (473) [105,147,148], arteannuin B (462) [105,147,149] and artemisinin (495) [105,147,150] are the most abundant representatives of this class of natural products”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [105]
In the citing paper
“and were amongst the first sesquiterpenes to be reported from A. annua.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [105]
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Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy
Efferth, T. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.009 · Cited by 632
Ferreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532
“18) was not effective against any of these tumor cells [117].”
BackgroundMedicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives
Dutra, R. C., Campos, M. M., Santos, A. R. S., & Calixto, J. Β. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.021 · Cited by 485
“The tannins epigallocatechin and epigallocatechin-3-gallate inhibit the incorporation of marked thymidine in gastric tumor cells, which indicates interference in their growth capacity [327].”
BackgroundThe Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363
Metadata
- Authors
- Zheng, G.-Q.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1994-02
- Volume
- 60
- Issue
- 01
- Pages
- 54-57
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2094117413
- Cited by
- 139
- References
- 0
- Citations by year
- 2025: 2 · 2024: 8 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 1 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 4 · 2012: 5
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r43ca056262-01a1)
- National Cancer Institute (CA 56262)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Keywords
- Artemisia annua, cytotoxicity, terpenoids, flavonoids, artemisinin, artemisinic acid, arteannuin B, stigmasterol, friedelin, artemetin, quercetagetin, anticancer activity, human cancer cell lines
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Drugs, Chinese Herbal, Flavonoids, Humans, Leukemia P388, Terpenes, Tumor Cells, Cultured, Molecular Structure, Mice
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