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Silybin Dihemisuccinate Protects Against Glutathione Depletion and Lipid Peroxidation Induced by Acetaminophen on Rat Liver
Abstract
Acetaminophen hepatotoxicity is characterized by glutathione depletion, cellular necrosis, and, in some instances, by the induction of lipid peroxidation. Silybin dihemisuccinate, a soluble form of the flavonoid silymarin, protects rats against liver glutathione depletion and lipid peroxidation induced by acute acetaminophen intoxication. Other biochemical parameters such as serum transaminases did not show the drastic increase observed under acetaminophen intoxication when animals were treated with the flavonoid. Preliminary results suggest that silybin dihemisuccinate may be another antidote against acetaminophen hepatotoxicity.
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Citations
Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Jaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 964
Dietary Antioxidant Compounds and Liver Health
Vitaglione, P., Morisco, F., Caporaso, N., & Fogliano, V. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490911701 · Cited by 305
Dehmlow, C., Erhard, J., & de Groot, H. (1996) · Hepatology · doi:10.1002/hep.510230415 · Cited by 290
Complementary and alternative medicine in chronic liver disease
Seeff, L. B., Lindsay, K. L., Bacon, B. R., Kresina, T. F., & Hoofnagle, J. H. (2001) · Hepatology · doi:10.1053/jhep.2001.27445 · Cited by 271
Metadata
- Authors
- Campos, R., Garrido, A., Guerra, R., & Valenzuela, A.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 1989-10
- Volume
- 55
- Issue
- 05
- Pages
- 417-419
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1990598218
- Cited by
- 180
- References
- 0
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Silybin Dihemisuccinate Protects Against Glutathione Depletion and Lipid Peroxidation Induced by Acetaminophen on Rat Liver. https://app.cochat.ai/papers/10.1055/s-2006-962055
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- Campos, R., Garrido, A., Guerra, R., & Valenzuela, A. (1989). Silybin Dihemisuccinate Protects Against Glutathione Depletion and Lipid Peroxidation Induced by Acetaminophen on Rat Liver. Planta Medica. https://doi.org/10.1055/s-2006-962055
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