Thyroid Hormone Restores Atrial Stretch-Induced Secretion of Atrial Natriuretic Peptide in Hypophysectomized Rats
Abstract
Acute blood volume expansion caused a rapid and profound release of atrial natriuretic peptides (ANP) from cardiac atria. The stimulated release of ANP was markedly blunted (more than 50%) in hypophysectomized rats (8 days after surgery). Daily subcutaneous injections of thyroxine (30 micrograms/kg) to hypophysectomized rats for 7 days, completely restored acute volume expansion induced release of ANP. Our data suggest that thyroid hormone is required for ANP secretion in response to acute volume expansion.
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Thyroid hormone can increase angiotensinogen and atrial natriuretic peptide levels and decrease vasopressin levels.
“thyroid hormone can increase angiotensinogen (16) and atrial natriuretic peptide levels (17,18) and respectively decrease vasopressin levels (19,20).”
From The Role of Thyroid Hormone in Blood Pressure Homeostasis: Evidence from Short-Term Hypothyroidism in Humans (2002) · cites this paper as [17]
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Fommei, E., & Iervasi, G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.1996 · Cited by 172 · see citing works
REGULATION OF NATRIURETIC PEPTIDE SECRETION BY THE HEART
Thibault, G., Amiri, F., & Garcia, R. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.193 · Cited by 83 · see citing works
Blood volume, hematocrit and hemorheology: The interrelationships
Isbister, J. P. (1994) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-1994-14301 · Cited by 7 · see citing works
Badauê‐Passos, D., Ventura, R. R., Silva, L. F. S., Olivares, E. L., Ramalho, M. J., Rodrigues, J. A., & Reis, L. C. (2001) · Experimental Physiology · doi:10.1113/eph8602189 · Cited by 6 · see citing works
Isbister, J. P. (1996) · Emergency Medicine Australasia · doi:10.1111/j.1442-2026.1996.tb00536.x · Cited by 1 · see citing works
- Authors
- Zamir, N., Slover, M., & Ohman, K.
- Affiliations
- Tel Aviv University (IL)
- Linköping University Hospital (SE)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1993-03
- Volume
- 25
- Issue
- 03
- Pages
- 152-155
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W1989842019
- Cited by
- 5
- References
- 0
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- thyroid hormones, thyroxine, atrial natriuretic peptide, ANP secretion, hypophysectomy, atrial stretch, blood volume expansion, pituitary hormone regulation
- MeSH terms
- Animals, Blood Pressure, Blood Volume, Heart Atria, Heart Rate, Hypophysectomy, Male, Atrial Natriuretic Factor, Pituitary Gland, Thyroxine, Atrial Function, Rats, Sprague-Dawley, Rats
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