Effect of methadone on TSH and thyroid hormone secretion
Abstract
The hypothalamus-pituitary-thyroid function was studied in 15 male patients on chronic methadone treatment (40 mg/day). No significant variations of TSH, T 4 , T 3 and rT 3 levels were documented, either in basal conditions or after TRH stimulation; however a reduced TSH pituitary response was recorded in some patients (6 out of 15). Key-Words: TSH - Thyroid Hormones - TRH - Opioid System - Methadone - Drug-Addicts
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Studies with dynamic thyrotropin-releasing hormone test performed in chronic opioid users have demonstrated conflicting results with enhanced, blunted, or no TSH response.
“Studies with dynamic thyrotropin-releasing hormone test performed in chronic opioid users have demonstrated conflicting results with enhanced (118), blunted (136, 155, 156), or no (74, 157) TSH response.”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [156]
Basal TSH values have been reported to be lower, unaffected, or increased in chronic opioid users.
“Furthermore, basal TSH values have been reported to be lower (149, 153), unaffected (74, 116, 136, 155-160), or increased (118, 161).”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [156]
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- Authors
- Vescovi, P., Gerra, G., Rastelli, G., Ceda, G., & Valenti, G.
- Affiliations
- University of Parma (IT)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 1984-01
- Volume
- 16
- Issue
- 01
- Pages
- 53-54
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W1989874438
- Cited by
- 11
- References
- 0
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- methadone, thyroid-stimulating hormone, thyroid hormones, thyrotropin-releasing hormone, hypothalamic-pituitary-thyroid axis, opioid use disorder, drug addicts, triiodothyronine, reverse T3
- MeSH terms
- Adult, Humans, Male, Methadone, Opioid-Related Disorders, Thyroid Hormones, Thyrotropin
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