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Serotonergic Agonists and Antagonists Affect Endurance Performance in the Rat
Abstract
The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p < 0.05) in a dose related manner by increasing dosages of quipazine dimaleate (QD: general 5-HT agonist) (0-5 mg.kg-1 i.p.) administered immediately prior to exercise (treadmill running at 20 m.min-1 and 5% grade). Conversely, RUN-EXH was increased (p < 0.05) by the greatest dosage of LY 53,857 (LY: 5-HT1C and 5-HT2 antagonist) (1.5 mg.kg-1 i.p.). Drug effects were similar in male and female rats. The negative effects of QD administration on RUN-EXH were not attenuated by administration of the peripherally restricted antagonist, xylamidine tosylate (up to 200 ug.kg-1 i.p.). The results of this investigation indicated that fatigue during prolonged exercise can be influenced by direct pharmacological administration of a serotonergic agonist and antagonist and that the mechanisms underlying these effects are likely to be central (brain) in nature.
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“Fatigue can set in during exercise when dopamine levels start to drop while serotonin levels are still elevated [98].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [98]
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Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911
“Additionally, studies have shown that decreasing serotonergic activity through intraperitoneal (IP) administration of a serotonergic antagonist increases the amount of time that rodents can run before they reach the point of exhaustion [219].”
BackgroundPossible mechanisms of central nervous system fatigue during exercise
Davis, J. M., & Bailey, S. P. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199701000-00008 · Cited by 686
Self-citationClark, A., & Mach, N. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0155-6 · Cited by 583
Exercise and Brain Neurotransmission
MEEUSEN, R. R., & Meirleir, K. D. (1995) · Sports Medicine · doi:10.2165/00007256-199520030-00004 · Cited by 548
MEEUSEN, R. R., Watson, P., Hasegawa, H., Roelands, B., & Piacentini, M. F. (2006) · Sports Medicine · doi:10.2165/00007256-200636100-00006 · Cited by 517
Metadata
- Authors
- Bailey, S., Davis, J., & Ahlborn, E.
- Affiliations
- University of South Carolina (US)
- ORCID
- Davis, J.
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1993-08
- Volume
- 14
- Issue
- 06
- Pages
- 330-333
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2002111073
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonergic agonists, serotonergic antagonists, endurance performance, xylazine, prolonged exercise, sex differences, central nervous system mechanisms
- MeSH terms
- Amidines, Animals, Dose-Response Relationship, Drug, Ergolines, Female, Injections, Intraperitoneal, Male, Physical Endurance, Placebos, Quipazine, Running, Serotonin Antagonists, Time Factors, Rats, Wistar, Rats
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