Cited by 115Cardiovascular and exercise physiologySports Performance and TrainingNeurotransmitter Receptor Influence on Behavior

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Serotonergic Agonists and Antagonists Affect Endurance Performance in the Rat

Bailey, S., Davis, J., Ahlborn, E.·1993·International Journal of Sports Medicine

DOI 10.1055/s-2007-1021187

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Abstract

The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p < 0.05) in a dose related manner by increasing dosages of quipazine dimaleate (QD: general 5-HT agonist) (0-5 mg.kg-1 i.p.) administered immediately prior to exercise (treadmill running at 20 m.min-1 and 5% grade). Conversely, RUN-EXH was increased (p < 0.05) by the greatest dosage of LY 53,857 (LY: 5-HT1C and 5-HT2 antagonist) (1.5 mg.kg-1 i.p.). Drug effects were similar in male and female rats. The negative effects of QD administration on RUN-EXH were not attenuated by administration of the peripherally restricted antagonist, xylamidine tosylate (up to 200 ug.kg-1 i.p.). The results of this investigation indicated that fatigue during prolonged exercise can be influenced by direct pharmacological administration of a serotonergic agonist and antagonist and that the mechanisms underlying these effects are likely to be central (brain) in nature.

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Guezennec, C. Y. (2000) · Science & Sports · doi:10.1016/s0765-1597(00)80032-5 · Cited by 10
Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist
Dwyer, D., & Browning, J. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00774.x · Cited by 10
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Chronic Fatigue Syndrome
Hurwitz, B. E., Brownley, K. A., FLETCHER, M. A., et al. (2000) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v06n02_06 · Cited by 6
Effect of gender and jumping exercise on leukocyte number, dopamine and prolactin levels in horses
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“literature is the observation that, during physical activity, dopamine content and release are increased in brain areas rich in dopamine innervation (Bailey et al., 1993; Hasegawa et al., 2000; Hattori et al., 1994); whereas little information is available regarding its”
Background
La fatigue : mécanismes et conséquences
Chennaoui, M., Gomez-Mérino, D., Duclos, M., & Guezennec, C. Y. (2004) · Science & Sports · doi:10.1016/j.scispo.2004.05.006 · Cited by 7
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“선행연구들에서 운동의 효과로 보고된 기억력 증가, 생리적 인 안정, BDNF 발현 증가, 쥐의 해마 치상회의 세포 증식과 같은 뇌기능 활성과 뇌세포 생성을 유도하는 자극인자로는 GH, IGF-1, estrogen, serotonin 등이 보고 되었다[6,10,11, 28,46].”
Effect of Carcinogen 1,2-Dimethylhydrazine Treatment on Fiber Types in Skeletal Muscles of Male Wistar Rats
Smerdu, V., & Perše, M. (2017) · Physiological Research · doi:10.33549/physiolres.933508 · Cited by 4
“Since increased levels of brain serotonin are associated with increased fatigue (Bailey et al. 1993), increased daily activities of DMH-treated rats with presumably lower level of brain serotonin would be expected.”
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“Animal studies by Bailey et al. (1992) showed that drugs which enhanced brain 5-HT reduced treadmill run time in rats, while the opposite effect emerged with 5-HT antagonists (Bailey et al., 1993a and b).”
Background
Amino acids, ammonia and exercise in man
van Hall, G. (1996) · Research Publications (Maastricht University) · doi:10.26481/dis.19960913gh · Cited by 3
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(2008) · Springer eBooks · doi:10.1007/978-0-387-72577-2_5 · Cited by 1
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Mechanisms of fatigue during prolonged exercise in the heat
Bridge, M. (2002) · UPT. Syiah Kuala University Library (Syiah Kuala University) · Cited by 1
Sumatriptan reduces exercise capacity in healthy males: a peripheral effect of 5-hydroxytryptamine agonism?
McCann, G. P., CAHILL, H., Knipe, S., Muir, D. F., MACINTYRE, P. D., & HILLS, W. S. (2000) · Clinical Science · doi:10.1042/cs19990249 · Cited by 1
Muscle force production and neuromuscular fatigue responses to neuromuscular electrical stimulation and tendon vibration
Alahmari, S. K. M. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.236174 · Cited by 1
CONCENTRAÇÃO DE TRIPTOFANO E VARIÁVEIS CINEMÁTICAS A DIFERENTES PERCENTUAIS DA VELOCIDADE CRÍTICA NO NADO CRAWL
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Cuquetto, D. C., & do Amaral, F. T. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Authors: Bailey, S., Davis, J., & Ahlborn, E.
Affiliations: University of South Carolina (US)
ORCID: Davis, J.
Venue: International Journal of Sports Medicine
Publisher: Georg Thieme Verlag KG
Published: 1993-08
Volume: 14
Issue: 06
Pages: 330-333
ISSN: 0172-4622 (ISSN-L)
1439-3964
DOI: 10.1055/s-2007-1021187
OpenAlex: W2002111073
Cited by: 114
References: 0
Citations by year: 2026: 2 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 4
FWCI: 7.48
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: serotonergic agonists, serotonergic antagonists, endurance performance, xylazine, prolonged exercise, sex differences, central nervous system mechanisms
MeSH terms: Amidines, Animals, Dose-Response Relationship, Drug, Ergolines, Female, Injections, Intraperitoneal, Male, Physical Endurance, Placebos, Quipazine, Running, Serotonin Antagonists, Time Factors, Rats, Wistar, Rats

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Serotonergic Agonists and Antagonists Affect Endurance Performance in the Rat

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