Schisandrol A from Schisandra chinensis Reverses P-Glycoprotein-Mediated Multidrug Resistance by Affecting Pgp-Substrate Complexes

Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies

Szopa, A., Ekiert, R. J., & Ekiert, H. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9470-4 · Cited by 325 · see citing works

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

Shukla, S., Wu, C., & Ambudkar, S. V. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.2.205 · Cited by 253 · see citing works

Analysis of Schisandra chinensis and Schisandra sphenanthera

Lu, Y., & Chen, D.-F. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.09.070 · Cited by 249 · see citing works

Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

Wu, C., Ohnuma, S., & Ambudkar, S. V. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111795163887 · Cited by 172 · see citing works

Plant Adaptogens—History and Future Perspectives

Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works

Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms

Wang, X., Wang, N., Cheung, F., Lao, L., Li, C., & Feng, Y. (2015) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(15)60171-6 · Cited by 108 · see citing works

Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents

Kopustinskienė, D. M., & Bernatonienė, J. (2021) · Antioxidants · doi:10.3390/antiox10040620 · Cited by 105 · see citing works

Liposome-Encapsulated Doxorubicin Reverses Drug Resistance by Inhibiting P-Glycoprotein in Human Cancer Cells

Riganti, C., Voena, C., Kopecka, J., Corsetto, P. A., Montorfano, G., Enrico, E., Costamagna, C., Rizzo, A. M., Ghigo, D., & Bosìa, A. (2011) · Molecular Pharmaceutics · doi:10.1021/mp2001389 · Cited by 101 · see citing works

P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs

Eichhorn, T., & Efferth, T. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.08.053 · Cited by 99 · see citing works

Targeting multidrug resistance in cancer by natural chemosensitizers

Hamed, A. R., Abdel‐Azim, N. S., Shams, K. A., & Hammouda, F. M. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0043-8 · Cited by 84 · see citing works

Phytochemicals: Potential Lead Molecules for MDR Reversal

Tinoush, B., Shirdel, I., & Wink, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00832 · Cited by 83 · see citing works

Reversing Agents for ATP-Binding Cassette Drug Transporters

Lee, C. H. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-416-6_14 · Cited by 80 · see citing works

Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways

Muthusamy, G., Kanimozhi, G., Bharathiraja, P., Khan, H. A., Alhomida, A. S., Ekhzaimy, A. A., Brindha, G., & Prasad, N. R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111632 · Cited by 82 · see citing works

BZML, a novel colchicine binding site inhibitor, overcomes multidrug resistance in A549/Taxol cells by inhibiting P-gp function and inducing mitotic catastrophe

Bai, Z., Gao, M., Zhang, H., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.05.016 · Cited by 75 · see citing works

Schisandrin B Attenuates Cancer Invasion and Metastasis Via Inhibiting Epithelial-Mesenchymal Transition

Liu, Z., Zhang, B., Liu, K., Ding, Z., & Hu, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040480 · Cited by 69 · see citing works

In Vivo to In Vitro Effects of Six Bioactive Lignans of Wuzhi Tablet (Schisandra Sphenanthera Extract) on the CYP3A/P-glycoprotein–Mediated Absorption and Metabolism of Tacrolimus

Qin, X. L., Chen, X., Wang, Y., et al. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.053892 · Cited by 60 · see citing works

Schisandrin B Prevents Doxorubicin-Induced Chronic Cardiotoxicity and Enhances Its Anticancer Activity In Vivo

Xu, Y., Liu, Z., Sun, J., Pan, Q., Sun, F., Yan, Z., & Hu, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028335 · Cited by 55 · see citing works

Schisandrin B Prevents Doxorubicin-Induced Cardiotoxicity via Enhancing Glutathione Redox Cycling

Li, L., Pan, Q., Han, W., Liu, Z., Li, L., & Hu, X. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1579 · Cited by 53 · see citing works

Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer

Li, Y., Revalde, J. L., Reid, G., et al. (2010) · Drug Metabolism Reviews · doi:10.3109/03602531003758690 · Cited by 49 · see citing works

Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells

Gu, W., Liu, L., Fang, F., Huang, F., CHENG, B.-B., & Bai, L. (2013) · Oncology Reports · doi:10.3892/or.2013.2817 · Cited by 42 · see citing works

Traditional Chinese Medicine for Refractory Nephrotic Syndrome: Strategies and Promising Treatments

Wang, X., Wang, L., Tu, Y., et al. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/8746349 · Cited by 42 · see citing works

A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment

Ehambarampillai, D., & Wan, M. L. Y. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01096-z · Cited by 49 · see citing works

Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp

Zhang, Y., Shi, Y., Li, X., Du, R., Luo, G., Xia, L., Du, W., Zhai, H., Wu, K., Fan, D., et al. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.4.5483 · Cited by 38 · see citing works

Determination of deoxyschizandrin in rat plasma by LC–MS

Deng, X., Chen, X., Yin, R., et al. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.10.006 · Cited by 37 · see citing works

Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis

Wan, E. C. K., Tse, A. K., Yu, Z., et al. (2010) · Phytomedicine · doi:10.1016/j.phymed.2009.12.005 · Cited by 37 · see citing works

Wuzhi Tablet (Schisandra sphenanthera Extract) Is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who Are CYP3A5 Expressers: a Two-Phase Prospective Study

Li, J., Chen, S., Qin, X., et al. (2017) · Drug Metabolism and Disposition · doi:10.1124/dmd.117.076737 · Cited by 36 · see citing works

A pharmacokinetic and pharmacodynamic study of drug–drug interaction between ginsenoside Rg1, ginsenoside Rb1 and schizandrin after intravenous administration to rats

Zhan, S., Guo, W., Shao, Q., et al. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.01.014 · Cited by 33 · see citing works

Synthesis and biological evaluation of novel bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potent P-glycoprotein inhibitors

Gu, X., Ren, Z., Tang, X., Peng, H., Zhao, Q. J., Lai, Y., Peng, S., & Zhang, Y. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.02.034 · Cited by 32 · see citing works

Transport ofSchisandra chinensisextract and its biologically-active constituents across Caco-2 cell monolayers — an in-vitro model of intestinal transport

Madgula, V. L. M., Avula, B., Choi, Y. W., et al. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.3.0012 · Cited by 32 · see citing works

Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats

Jin, J., Bi, H., Hu, J., et al. (2010) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.705 · Cited by 30 · see citing works

In vitro to in vivo evidence of the inhibitor characteristics of Schisandra lignans toward P-glycoprotein

Liang, Y., Zhou, Y., Zhang, J., et al. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.04.005 · Cited by 28 · see citing works

A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities

Zhang, F., Zhai, J., Weng, N., Gao, J., Yin, J., & Chen, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.816036 · Cited by 30 · see citing works

A comprehensive review on Schisandrin and its pharmacological features

Wang, X., Wang, X., Yao, H., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02687-z · Cited by 26 · see citing works

Simultaneous determination of 10 active components in traditional Chinese medicine “YIGONG” capsule by RP-HPLC–DAD

Feng, C., Cai, Y., & Ruan, J. (2008) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2008.01.019 · Cited by 22 · see citing works

A novel indirubin derivative PHII-7 potentiates adriamycin cytotoxicity via inhibiting P-glycoprotein expression in human breast cancer MCF-7/ADR cells

Shi, R., Li, W., Zhang, X., et al. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.047 · Cited by 21 · see citing works

Gomisin L1, a Lignan Isolated from Schisandra Berries, Induces Apoptosis by Regulating NADPH Oxidase in Human Ovarian Cancer Cells

Ko, Y. H., Jeong, M., Jang, D. S., et al. (2021) · Life · doi:10.3390/life11080858 · Cited by 18 · see citing works

Quantitative Analysis and Fingerprint Profiles for Quality Control of Fructus Schisandrae by Gas Chromatography: Mass Spectrometry

Xia, Y., Yang, B., Liang, J., et al. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/806759 · Cited by 18 · see citing works

Reversion of P-glycoprotein-mediated multidrug resistance in human leukemic cell line by carnosic acid.

Yu, X.-N., Chen, X., Li, H., et al. (2008) · PubMed · Cited by 17 · see citing works

Synthesis and evaluation of substituted dibenzo[c,e]azepine-5-ones as P-glycoprotein-mediated multidrug resistance reversal agents

Tang, X., Gu, X., Ren, Z., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.03.005 · Cited by 17 · see citing works

Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice

Duan, M., Zhang, W., Yang, Y., Su, X., Xu, D.-Y., Yan, Y.-L., & Gao, Q. (2016) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.195552 · Cited by 13 · see citing works

Effects of schisandra lignans on the absorption of protopanaxadiol-type ginsenosides mediated by P-glycoprotein and protopanaxatriol-type ginsenosides mediated by CYP3A4

Li, Y., Yang, K., Zhao, L., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117057 · Cited by 11 · see citing works

Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients

Zhang, Z., Lu, X., Dong, L., et al. (2019) · Medicine · doi:10.1097/md.0000000000018150 · Cited by 11 · see citing works

Synthesis of the first unnatural schisantherins and their effects in multidrug-resistant cancer cells

Schobert, R., Kern, W., Milius, W., et al. (2008) · Tetrahedron Letters · doi:10.1016/j.tetlet.2008.03.134 · Cited by 11 · see citing works

Multidrug Resistance in Cancer: A Tale of ABC Drug Transporters

Kapoor, K., Sim, H. M., & Ambudkar, S. V. (2013) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-1-4614-7070-0_1 · Cited by 11 · see citing works

Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents

Deng, L., Cheng, S., Jiang, L., Xu, X., Hao, X., Fan, Y., & Mu, S. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113919 · Cited by 10 · see citing works

Wuweizisu C fromSchisandra chinensisdecreases membrane potential in C6 glioma cells1

Choi, Y. W., Kim, K., Jo, J.-Y., Kim, H.-L., Lee, Y., Woo-jung, S. H. I. N., Sacket, S. J., Han, M., & Im, D. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00838.x · Cited by 8 · see citing works

[Grapefruit juice: potential drug interaction].

Palumbo, G., Bacchi, S., Palumbo, P., et al. (2005) · PubMed · Cited by 8 · see citing works

Prevention and Treatment of Doxorubicin-Induced Cardiotoxicity by Dexrazoxane and Schisandrin B in Rabbits

Che, F., Liu, Y., & Xu, C. (2011) · International Journal of Toxicology · doi:10.1177/1091581811415873 · Cited by 7 · see citing works

Prediction of tacrolimus and Wuzhi tablet pharmacokinetic interaction magnitude in renal transplant recipients

Chen, P., Dai, R., She, Y., et al. (2022) · Clinical Transplantation · doi:10.1111/ctr.14807 · Cited by 4 · see citing works

Comparative Phytochemical Analysis of Chinese and Bay Starvine (Schisandraspp.): Potential for Development as a New Dietary Supplement Ingredient

Lyles, J. T., Tyler, P., Bradbury, E. J., Nelson, K., Brown, C. F., Pierce, S., & Quave, C. L. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2017.1304483 · Cited by 4 · see citing works

Inhibition of ATP-Binding Cassette Transporters by Chinese Herbs and Phytochemicals

Efferth, T. (2012) · Springer eBooks · doi:10.1007/978-3-7091-0442-2_7 · Cited by 3 · see citing works

Adaptogens - use, history and future

Marciniak, A., Nemeczek, S., Walczak, K., Walczak, P., MERKISZ, K., Grzybowski, J., Grzywna, N., JASKUŁA, K., & ORŁOWSKI, W. (2023) · Quality in Sport · doi:10.12775/qs.2023.09.01.002 · Cited by 3 · see citing works

Chinese Herbal Medicines as Reversal Agents for P-glycoprotein-mediated Multidrug Resistance in Tumors

Shen, X., Hu, Y., Yu, Z., et al. (2010) · Chinese Journal of Natural Medicines · doi:10.3724/sp.j.1009.2009.00465 · Cited by 2 · see citing works

Shengmai Suppressed Vascular Tension in Umbilical Arteries and Veins of Human and Sheep

Yin, X., Gu, X., He, Y., et al. (2015) · Pharmacology &amp Pharmacy · doi:10.4236/pp.2015.66030

Schisandra chinensis 五味子(Wuweizi, Chinese Magnoliavine)

Zhu, J.-J. (2015) · Springer eBooks · doi:10.1007/978-3-211-99448-1_59

Pharmacological profile of dibenzocyclooctadiene lignans and other active ingredients in Schisadrae Fructus

Ko, R. K.-M., Chen, N., Leong, P. K., & Ma, C. W. (2014) · Rare & Special e-Zone (The Hong Kong University of Science and Technology) · doi:10.1142/9789814635936_0004

The impact of P-glycoprotein mediated efflux on absorption of 11 sedating and less-sedating antihistamines using Caco-2 monolayers

Crowe, A. P., & Wright, C. M. (2011) · Xenobiotica · doi:10.3109/00498254.2011.643256 · Cited by 35 · see citing works

The detection of rhodamine 123 efflux at low levels of drug resistance

Webb, M., Raphael, C. L., Asbahr, H., et al. (1996) · British Journal of Haematology · doi:10.1046/j.1365-2141.1996.d01-1680.x · Cited by 43 · see citing works

Efflux of Rhodamine From CD56+ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833

Robey, R. W., Bakke, S., Stein, W. D., et al. (1999) · Blood · doi:10.1182/blood.v93.1.306.401k42_306_314 · Cited by 7 · see citing works

Efflux of Rhodamine From CD56+ Cells as a Surrogate Marker for Reversal of P-Glycoprotein–Mediated Drug Efflux by PSC 833

Robey, R. W., Bakke, S., Stein, W. D., et al. (1999) · Blood · doi:10.1182/blood.v93.1.306 · Cited by 63 · see citing works

Inhibition of P-glycoprotein-mediated efflux by thiolated cyclodextrins

Veider, F., Haddadzadegan, S., Armengol, E. S., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121648 · Cited by 21 · see citing works