Cited by 49Drug Transport and Resistance MechanismsPlant-derived Lignans Synthesis and BioactivityPharmacogenetics and Drug Metabolism

Effects of Schisandra Lignans on P-Glycoprotein-Mediated Drug Efflux in Human Intestinal Caco-2 Cells

Yoo, Hye, Lee, Mijin, Lee, Min, Lim, Sun, Shin, Jongheon, Kim, Dong-Hyun·2007·Planta Medica

Abstract

Schisandra fruits (Schisandraceae) are often used in traditional medicine and can be taken concomitantly with conventional medicine. In this study, the effects of dibenzocyclooctadiene lignans from Schizandra chinensis on P-gp-mediated efflux were examined to investigate a possible interaction with P-gp substrates. The cellular accumulation of rhodamine-123 in Caco-2 cells was measured with 12 Schisandra lignans. Most compounds resulted in slight or moderate increases of rhodamin-123 cellular uptake, indicating their P-gp inhibitory activity. Among them, deoxyschizandrin exhibited the most potent effect on the accumulation of rhodamine-123. Subsequently, bidirectional transports of digoxin and rhodamine-123 in Caco-2 cells were determined with deoxyschizandrin, the most active compound for the rhodamine-123 assay. In the bidirectional transport study, apical-to-basal (A-to-B) transports of digoxin and rhodamine-123 were increased, whereas basal-to-apical (B-to-A) transports were decreased by deoxyschizandrin in concentration- and time-dependent manners. At 50 microM of deoxyschizandrin, the transport ratios (B-A/A-B) for digoxin and rhodamine-123 were 2.2 and 2.1 compared with the control ratios of 15.2 and 12.2, respectively. These results demonstrated that deoxyschizandrin effectively inhibited the P-gp-mediated efflux in Caco-2 cells, suggesting they could potentially increase the absorption of drugs that can act as a P-gp substrate.

Integrity signals

Registry

Crossref · 10.1055/s-2007-967178

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several studies reported that some lignans (gomisin A, gomisin G, schizandrin, and schisanhenol) possess antitumor bioactivities.

    “Several studies reported that some lignans (gomisin A, gomisin G, schizandrin, and schisanhenol) possess antitumor bioactivities [94,95,96,97,98].”

    From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [95]

Cited by

Sorted by citations

Authors
Yoo, H., Lee, M., Lee, M., Lim, S., Shin, J., & Kim, D.-H.
Affiliations
  • Korea Institute of Science and Technology (KR)
  • Seoul National University (KR)
Venue
Planta Medica
Published
2007-05
Volume
73
Issue
5
Pages
444-450
ISSN
  • 0032-0943 (ISSN-L)
  • 1439-0221
OpenAlex
W2085064931
Cited by
49
References
0
Citations by year
2025: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 2 · 2014: 7 · 2013: 5 · 2012: 8
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • Planta Medica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant-derived Lignans Synthesis and Bioactivity
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
Schisandra chinensis, dibenzocyclooctadiene lignans, deoxyschizandrin, P-glycoprotein, drug efflux inhibition, intestinal drug absorption, Caco-2 cells, rhodamine 123 accumulation, bidirectional transport, digoxin, drug-drug interactions, traditional medicine
MeSH terms
Biological Transport, Digoxin, Humans, Polycyclic Compounds, Lignans, Caco-2 Cells, Rhodamine 123, ATP Binding Cassette Transporter, Subfamily B, Member 1, Schisandra, Cyclooctanes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review