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Cited by 51Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

Treatment of Subclinical Hypothyroidism Reduces Atherogenic Lipid Levels in a Placebo-controlled Double-blind Clinical Trial

Teixeira, P., Reuters, V., Ferreira, M., Almeida, C., Reis, F., Melo, B., Buescu, A., Costa, A. +1 more·2008·Hormone and Metabolic Research
DOI 10.1055/s-2007-993216
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Abstract

Many studies have found clinical and metabolic alterations in subclinical hypothyroidism, however, there are disagreements about the benefits of levothyroxine therapy. The objective of the present study was to analyze the effects of 6 months of treatment on the lipid profile of patients with subclinical hypothyroidism. A randomized double blind, placebo-controlled clinical assay was conducted. Sixty patients were enrolled in stratified random allocation by TSH levels that generated similar groups in average: free thyroxine levels, lipid levels, age, clinical score, and sedentary. At 6 months, 18 patients in the levothyroxine and 20 in the placebo group were reevaluated and a fall in all atherogenic lipid variables was observed with treatment. The TC and LDL-c variations (-22.6+/-37.2 and -18.5+/-34.6 mg/dl, respectively) in the group that received LT4 were statistically different (p=0.023 and p=0.012) from those occurring in the placebo group (+7.3+/-37.1 and +14.7+/-40.6 mg/dl). Baseline characteristics associated with better improvement in the levels of TC and LDL-c were the presence of TPO-Ab, TSH levels >8.0 microUI/ml, Body Mass Index >or=25 kg/m2, and the presence of menopause. We concluded that treatment with dose-adjusted levothyroxine reduced atherogenic lipid levels in some patients. Further studies to determine the effects of LT4 replacement in specific subgroups of SH patients are still necessary, especially in patients with TSH <8.0 microUI/ml.

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Authors
Teixeira, P., Reuters, V., Ferreira, M., Almeida, C., Reis, F., Melo, B., Buescu, A., Costa, A., & Vaisman, M.
Affiliations
Universidade Federal do Rio de Janeiro (BR)
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2008-01
Volume
40
Issue
1
Pages
50-55
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2007-993216
OpenAlex
W2077977355
Cited by
51
References
0
Citations by year
2025: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 1 · 2014: 8 · 2013: 2 · 2012: 7
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, levothyroxine, lipid profile, atherogenic lipids, total cholesterol, LDL cholesterol, thyroid-stimulating hormone, thyroid peroxidase antibodies, menopause, body mass index, hypercholesterolemia
MeSH terms
Double-Blind Method, Female, Humans, Hypothyroidism, Male, Menopause, Placebos, Thyroxine, Atherosclerosis, Lipid Metabolism

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