Clinical Significance of Liver Dysfunction in Pregnancy-Induced Hypertension1
Abstract
Hepatic dysfunction is one of the frequent manifestations of multisystemic involvement in preeclampsia. This study was conducted to establish the impact of liver dysfunction on maternal and neonatal outcome in women with pregnancy-induced hypertension (PIH). The prevalence of liver dysfunction as determined by an elevated serum glutamic oxalacetic transaminase (SGOT) concentration was 21% in a population of 355 patients with PIH. Liver dysfunction was associated with the presence of severe hypertension, proteinuria, a lower platelet count, and renal compromise (elevated blood urea nitrogen, creatinine, and uric acid serum concentrations). Abdominal pain was also associated with an SGOT elevation. Liver dysfunction was associated with intrauterine growth retardation and prematurity. Furthermore, the association with these neonatal complications was independent from the severity of the hypertension and the presence of proteinuria. Thus, we conclude that liver dysfunction is a frequent complication of PIH and that it is an independent risk factor for maternal and perinatal complications.
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The condition produced by sVEGFR1 and soluble endoglin in animals is indistinguishable from the HELLP syndrome observed in humans.
“This condition is indistinguishable from the HELLP syndrome observed in humans(181–184).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [182]
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- Authors
- Romero, R., Vizoso, J., Emamian, M., Duffy, T., Riely, C., Halford, T., Oyarzun, E., Naftolin, F., & Hobbins, J.
- Affiliations
- Yale University (US)
- Venue
- American Journal of Perinatology
- Publisher
- Georg Thieme Verlag KG
- Published
- 1988-04
- Volume
- 5
- Issue
- 02
- Pages
- 146-151
- ISSN
- 0735-1631 (ISSN-L)
- 1098-8785
- OpenAlex
- W2059557319
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2018: 2 · 2017: 5 · 2014: 1 · 2013: 7
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- liver dysfunction, gestational hypertension, preeclampsia, aspartate aminotransferase, maternal complications, neonatal complications, fetal growth restriction, preterm birth, proteinuria, severe hypertension, abdominal pain
- MeSH terms
- Aspartate Aminotransferases, Blood Pressure, Cesarean Section, Female, Humans, Hypertension, Infant, Newborn, Infant, Newborn, Diseases, Liver Diseases, Models, Theoretical, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Trimester, Third, Regression Analysis
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