Cited by 221Cardiovascular and exercise physiologySports Performance and TrainingMuscle metabolism and nutrition

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Structural changes in skeletal muscle tissue with heavy-resistance exercise

Lüthi, J., Howald*, H., Claassen, H., Rösler, K., Vock**, P., Hoppeler, H.·1986·International Journal of Sports Medicine

DOI 10.1055/s-2008-1025748

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Abstract

Muscle strength, muscle cross-sectional area, fiber size, fiber type distribution, capillarity, and mitochondrial volume were estimated before and after 6 weeks of heavy-resistance exercise. Isokinetic torque production of the knee extensor muscles increased by a total of 17.6%, mainly during the first half of the training period. The cross-sectional area of the vastus lateralis muscle increased by 8.4%, mainly during the second half of the training period. Morphometrically determined fiber size, fiber type distribution, and capillarity from biopsies of vastus lateralis did not change significantly with training. Likewise, the surface densities of inner and outer mitochondrial membranes as well as the volume density of myofibrils remained unchanged. In contrast, the volume density of mitochondria decreased by 9.6%. However, due to the increase in total muscle volume, the calculated absolute volume of mitochondria remained constant, whereas the absolute volume of myofibrils increased by 10%. It is concluded that strength training of short duration in previously untrained young male subjects does not change the ultrastructural composition of mitochondria and that the apparent dilution of mitochondria can quantitatively be accounted for by the increase in myofibrillar volume.

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Authors: Lüthi, J., Howald*, H., Claassen, H., Rösler, K., Vock**, P., & Hoppeler, H.
Venue: International Journal of Sports Medicine
Publisher: Georg Thieme Verlag KG
Published: 1986-06
Volume: 07
Issue: 03
Pages: 123-127
ISSN: 0172-4622 (ISSN-L)
1439-3964
DOI: 10.1055/s-2008-1025748
OpenAlex: W2077181738
Cited by: 221
References: 0
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 14 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 12 · 2012: 4
FWCI: 10.48
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: heavy resistance exercise, skeletal muscle ultrastructure, resistance training, vastus lateralis, muscle cross-sectional area, fiber type distribution, capillarity, mitochondrial volume, isokinetic torque, knee extensors, muscle hypertrophy
MeSH terms: Adenosine Triphosphatases, Adolescent, Adult, Biopsy, Physical Exertion, Histocytochemistry, Humans, Isotonic Contraction, Male, Mitochondria, Muscle, Muscles, Myofibrils, Physical Education and Training, Time Factors, Tomography, X-Ray Computed

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Structural changes in skeletal muscle tissue with heavy-resistance exercise

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