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Structural changes in skeletal muscle tissue with heavy-resistance exercise
Abstract
Muscle strength, muscle cross-sectional area, fiber size, fiber type distribution, capillarity, and mitochondrial volume were estimated before and after 6 weeks of heavy-resistance exercise. Isokinetic torque production of the knee extensor muscles increased by a total of 17.6%, mainly during the first half of the training period. The cross-sectional area of the vastus lateralis muscle increased by 8.4%, mainly during the second half of the training period. Morphometrically determined fiber size, fiber type distribution, and capillarity from biopsies of vastus lateralis did not change significantly with training. Likewise, the surface densities of inner and outer mitochondrial membranes as well as the volume density of myofibrils remained unchanged. In contrast, the volume density of mitochondria decreased by 9.6%. However, due to the increase in total muscle volume, the calculated absolute volume of mitochondria remained constant, whereas the absolute volume of myofibrils increased by 10%. It is concluded that strength training of short duration in previously untrained young male subjects does not change the ultrastructural composition of mitochondria and that the apparent dilution of mitochondria can quantitatively be accounted for by the increase in myofibrillar volume.
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“Separate reports have also shown that resistance training does not alter or decreases mitochondrial volume (as measured by citrate synthase activity assays or transmission electron microscopy; Macdougall et al., 1982; Luthi et al., 1986; Tesch et al., 1987; Parise et al., 2005; Porter et al., 2015)”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Luthi et al., 1986
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Metadata
- Authors
- Lüthi, J., Howald*, H., Claassen, H., Rösler, K., Vock**, P., & Hoppeler, H.
- Venue
- International Journal of Sports Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 1986-06
- Volume
- 07
- Issue
- 03
- Pages
- 123-127
- ISSN
- 0172-4622 (ISSN-L)
- 1439-3964
- OpenAlex
- W2077181738
- Cited by
- 221
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 14 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 12 · 2012: 4
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- heavy resistance exercise, skeletal muscle ultrastructure, resistance training, vastus lateralis, muscle cross-sectional area, fiber type distribution, capillarity, mitochondrial volume, isokinetic torque, knee extensors, muscle hypertrophy
- MeSH terms
- Adenosine Triphosphatases, Adolescent, Adult, Biopsy, Physical Exertion, Histocytochemistry, Humans, Isotonic Contraction, Male, Mitochondria, Muscle, Muscles, Myofibrils, Physical Education and Training, Time Factors, Tomography, X-Ray Computed
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