Z-Transformed EEG Power Spectra of Children with Down Syndrome vs a Control Group
Abstract
Standardized EEG records of eighty-eight children with Down syndrome aged between six months and five years were analysed. The EEGs were digitalized, evaluated by spectral analysis, and subjected to z-transformation, a method which allows a direct comparison of the Down syndrome children with a normal control group (Munich Developmental Longitudinal Study). The results show a significant increase in absolute power, especially theta power; the absolute alpha power is less markedly increased or even decreased. The most significant differences, however, are observed when calculating the relative alpha power. Children with Down syndrome show a reduced relative alpha power already at the age of six months, and this reduction becomes even more prominent with growing age.
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Children with DS as young as 6 months of age show significantly reduced alpha power, implicated in working memory, relative to age-matched controls.
“For example, children as young as 6 months of age show significantly reduced alpha power, implicated in working memory, relative to age-matched controls138.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [138]
In children with DS, oscillatory networks involved in memory consolidation are disrupted within the first postnatal months.
“Network-level functional analyses of infants and toddlers with DS are scarce, but evidence from early EEG studies suggests that oscillatory networks involved in memory consolidation are disrupted within the first postnatal months in children with DS136–138.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [138]
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Self-citation
- Authors
- Schmid, R., Sadowsky, K., Weinmann, H., Tirsch, W., & Pöppl, S.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Technical University of Munich (DE)
- Helmholtz Munich (DE)
- ORCID
- Schmid, R.
- Venue
- Neuropediatrics
- Publisher
- Georg Thieme Verlag KG
- Published
- 1985-11
- Volume
- 16
- Issue
- 04
- Pages
- 218-224
- ISSN
- 0174-304X (ISSN-L)
- 1439-1899
- OpenAlex
- W1993061766
- Cited by
- 19
- References
- 0
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2 · 2019: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Down syndrome, EEG power spectra, z-transform, theta power, alpha power, absolute power, infants, children
- MeSH terms
- Child, Child, Preschool, Down Syndrome, Electroencephalography, Evoked Potentials, Frontal Lobe, Humans, Infant, Occipital Lobe, Parietal Lobe
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