Die Prävalenz des Gilbert-Syndroms in Deutschland

Sieg, A.; Arab, L.; Schlierf, G.; Stiehl, A.; Kommerell, B.

doi:10.1055/s-2008-1068222

Cited by 80Neonatal Health and BiochemistryPediatric Hepatobiliary Diseases and TreatmentsHeme Oxygenase-1 and Carbon Monoxide

Die Prävalenz des Gilbert-Syndroms in Deutschland

Sieg, A., Arab, L., Schlierf, G., Stiehl, A., Kommerell, B.·2008·DMW - Deutsche Medizinische Wochenschrift

DOI 10.1055/s-2008-1068222

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Abstract

The prevalence of Gilbert's syndrome was studied in a randomized group of 1530 persons (785 men and 745 women, aged 20-40 years) living in the Heidelberg region of the Federal Republic of Germany. It was found to be present in 12.4% of men and 4.8% of women, i.e. a total of 8.6% for the entire group. In women the serum bilirubin level (mean 12.0 +/- 5.1 mumol/l) was significantly lower than in men (mean of 13.7 +/- 6.8 mumol/l; P less than 0.001). Analysing the frequency distribution of serum bilirubin revealed that patients with this syndrome do not constitute a population of its own, but rather form the upper end of the normative bilirubin distribution curve.

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Meulengracht-Gilbert Syndrome (MGS) is a benign genetic disorder present in approximately 10% of young men in Bavaria, and it affects bilirubin processing leading to elevated levels of unconjugated bilirubin in the blood.
“Meulengracht-Gilbert Syndrome (MGS), a benign genetic disorder which is present in approximately 10% of young men in Bavaria and affects bilirubin processing leading to elevated levels of unconjugated bilirubin in the blood [14], [15], [16].”
From Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial (2021) · cites this paper as [14]

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Authors: Sieg, A., Arab, L., Schlierf, G., Stiehl, A., & Kommerell, B.
Affiliations: Heidelberg University (DE)
ORCID: Sieg, A.
Arab, L.
Venue: DMW - Deutsche Medizinische Wochenschrift
Publisher: Georg Thieme Verlag KG
Published: 2008-03-25
Volume: 112
Issue: 31/32
Pages: 1206-1208
ISSN: 0012-0472 (ISSN-L)
1439-4413
DOI: 10.1055/s-2008-1068222
OpenAlex: W2402765863
Cited by: 79
References: 0
Citations by year: 2025: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 3
FWCI: 3.89
Type: journal article
Language: de
Open access: closed
Locations: DMW - Deutsche Medizinische Wochenschrift (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Keywords: Gilbert syndrome, prevalence, serum bilirubin, sex differences, unconjugated hyperbilirubinemia, young adults
MeSH terms: Adult, Female, Germany, West, Gilbert Disease, Humans, Hyperbilirubinemia, Hereditary, Male

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Die Prävalenz des Gilbert-Syndroms in Deutschland

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