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Madecassoside Isolated from Centella asiatica Herbs Facilitates Burn Wound Healing in Mice
Abstract
The current study was designed to investigate the effect of madecassoside, the major triterpene in CENTELLA ASIATICA, on burn wound healing and its possible mechanism of action. An oral administration of madecassoside (6, 12, 24 mg/kg) facilitated wound closure in a time-dependent manner and reached its peak effect, nearly completely wound closure, on day 20 in the group receiving the highest dose of 24 mg/kg of madecassoside. Further histopathological analysis revealed that madecassoside alleviated infiltration of inflammatory cells as well as enhanced epithelisation resulting from dermal proliferation of fibroblasts. Madecassoside at higher doses (12 and 24 mg/kg) decreased nitric oxide (NO) levels and malondialdehyde (MDA) content in the burn skin tissue. However, reduced glutathione (GSH) and hydroxyproline levels were increased in the same skin tissue. In addition, madecassoside promoted skin angiogenesis IN VIVO, correlating with our findings IN VITRO that it stimulated endothelial cell growth in a rat aortic ring assay. These data suggest that madecassoside has significant wound-healing activity and is one of the major reasons for the use of C. ASIATICA herbs in the successful treatment of burn injury. Moreover, the results from the present study indicate that the effect of madecassoside on wound healing may involve several mechanisms including antioxidative activity, collagen synthesis and angiogenesis.
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“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [30]
In the citing paper
“Madecassoside has significant wound‐healing activity based on several mechanisms including anti‐inflammatory and antioxidative activity, collagen synthesis and angiogenesis”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [100]
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Metadata
- Authors
- Liu, M., Dai, Y., Li, Y., Luo, Y., Huang, F., Gong, Z., & Meng, Q.
- Affiliations
- China Pharmaceutical University (CN)
- Nanjing Normal University (CN)
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2008-06
- Volume
- 74
- Issue
- 08
- Pages
- 809-815
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W1989354404
- Cited by
- 142
- References
- 0
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 20 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Planta Medica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Keywords
- madecassoside, Centella asiatica, burn wound healing, triterpenoids, angiogenesis, re-epithelialization, fibroblast proliferation, oxidative stress, antioxidant activity, collagen synthesis, nitric oxide, malondialdehyde, reduced glutathione, hydroxyproline, endothelial cell growth, anti-inflammatory activity
- MeSH terms
- Animals, Burns, Collagen, Male, Phytotherapy, Mice, Inbred ICR, Triterpenes, Wound Healing, Lipid Peroxidation, Neovascularization, Physiologic, Centella, Mice
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