Cited by 142Wound Healing and TreatmentsMedicinal Plants and NeuroprotectionNatural product bioactivities and synthesis

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Madecassoside Isolated from Centella asiatica Herbs Facilitates Burn Wound Healing in Mice

Liu, Mei, Dai, Yue, Li, Ying, Luo, Yubin, Huang, Fang, Gong, Zhunan, Meng, Qingyu·2008·Planta Medica

DOI 10.1055/s-2008-1074533

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Abstract

The current study was designed to investigate the effect of madecassoside, the major triterpene in CENTELLA ASIATICA, on burn wound healing and its possible mechanism of action. An oral administration of madecassoside (6, 12, 24 mg/kg) facilitated wound closure in a time-dependent manner and reached its peak effect, nearly completely wound closure, on day 20 in the group receiving the highest dose of 24 mg/kg of madecassoside. Further histopathological analysis revealed that madecassoside alleviated infiltration of inflammatory cells as well as enhanced epithelisation resulting from dermal proliferation of fibroblasts. Madecassoside at higher doses (12 and 24 mg/kg) decreased nitric oxide (NO) levels and malondialdehyde (MDA) content in the burn skin tissue. However, reduced glutathione (GSH) and hydroxyproline levels were increased in the same skin tissue. In addition, madecassoside promoted skin angiogenesis IN VIVO, correlating with our findings IN VITRO that it stimulated endothelial cell growth in a rat aortic ring assay. These data suggest that madecassoside has significant wound-healing activity and is one of the major reasons for the use of C. ASIATICA herbs in the successful treatment of burn injury. Moreover, the results from the present study indicate that the effect of madecassoside on wound healing may involve several mechanisms including antioxidative activity, collagen synthesis and angiogenesis.

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“[17] Liu M, Dai Y, Li Y, Luo Y, Huang F, Gong Z, et al.”
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Kepekçi, R. A., İlçe, B. Y., & Kanmazalp, S. D. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819489-8.00001-6 · Cited by 21
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Limpanasithikul, W., Kwansang, J., & Itthipanichpong, C. (2015) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/2231-4040.157984 · Cited by 20
MAD ointment ameliorates Imiquimod-induced psoriasiform dermatitis by inhibiting the IL-23/IL-17 axis in mice
Ouyang, Q., Pan, Y., Luo, H., Xuan, C.-X., Liu, J., & Liu, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.08.013 · Cited by 19
Evaluation of a topical herbal patch for soft tissue wound healing: an animal study
Chaushu, L., Weinreb, M., Beitlitum, I., Moses, O., & Nemcovsky, C. E. (2015) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12372 · Cited by 18
“2004), alleviate infiltration of inflammatory cells, enhance epithelialization resulting from fibroblasts proliferation and promote angiogenesis (Liu et al. 2008).”
Background
Cholinergic system is involved in the therapeutic effect of madecassoside on collagen-induced arthritis in rats
Dou, Y., Luo, J., Yu, J., Xia, Y., & Dai, Y. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105813 · Cited by 18
Self-citation
Plant-based Natural Products for Wound Healing: A Critical Review
Chandrasekar, M., Ramalingam, S., & Nanjan, M. J. (2021) · Current Drug Research Reviews · doi:10.2174/2589977513666211005095613 · Cited by 17
A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats
Wang, T., Dan-dan, L., Fei-Fei, G. A. O., Jiang, C., Xia, Y., & Dai, Y. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60138-2 · Cited by 17
Self-citation
Centella asiatica modulates neuron cell survival by altering caspase-9 pathway
Omar, N. S., Zakaria, Z. A. C., Then, S., Ngah, W. Z. W., & Mazlan, M. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000323 · Cited by 17
Ethnomedicinal Plants
Rı́os, J. L. (2011) · Science Publishers eBooks · doi:10.1201/b10495-2 · Cited by 17
Potential Activities of Centella asiatica Leaf Extract against Pathogenic Bacteria‐Associated Biofilms and Its Anti‐Inflammatory Effects
Chonsut, P., Romyasamit, C., Konyanee, A., Niyomtham, N., Goodla, L., & Mordmuang, A. (2024) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2024/5959077 · Cited by 17
Therapeutic potential of traditional Chinese medicine loaded nanocarriers in wound management: Current status and their future perspective
Gupta, J., Kumar, D., Gupta, R., Diwakar, D., Shanno, K., Tripathi, A. K., Kumar, A., & Kumar, M. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100622 · Cited by 16
Madecassoside induces apoptosis of keloid fibroblasts via a mitochondrial‐dependent pathway
Song, J., Dai, Y., Bian, D., Zhang, H., Xu, X., Xia, Y., & Gong, Z. (2010) · Drug Development Research · doi:10.1002/ddr.20432 · Cited by 15
“asiatica herbs, alleviated infiltration of inflammatory cells, fostered re-epithelialization to obtain almost complete wound closure and a better healing pattern in the burned skin of mice [Liu et al., 2008].”
BackgroundSelf-citation
Current Approaches in Healing of Wounds in Diabetes and Diabetic Foot Ulcers
Gupta, S., Chauhan, S., Chalotra, R., Rathi, A., Saini, M., deol, S., & Lard, M. (2022) · Current Bioactive Compounds · doi:10.2174/1573407218666220823111344 · Cited by 15
Gypenoside LXXV Promotes Cutaneous Wound Healing In Vivo by Enhancing Connective Tissue Growth Factor Levels Via the Glucocorticoid Receptor Pathway
Park, S., Ko, E., Lee, J. H., Song, Y., Cui, C.-H., Hou, J., Jeon, B.-M., Kim, H. S., & Kim, S. C. (2019) · Molecules · doi:10.3390/molecules24081595 · Cited by 14
Investigation of the in vitro antibacterial, cytotoxic and in vivo analgesic effects of silver nanoparticles coated with Centella asiatica plant extract
Bozkaya, O., Ekici, H., Gök, Z. G., Bozkaya, E., Ekici, S., Yiğitoğlu, M., & Vargel, İ. (2022) · Ankara Üniversitesi Veteriner Fakültesi Dergisi · doi:10.33988/auvfd.1014802 · Cited by 14
Herbal bioactives for wound healing application
Bakshi, I. S., Chopra, H., Sharma, M., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824385-5.00003-0 · Cited by 13
Centella asiatica extract‐SiO 2 nanocomposite: More than a drug‐delivery system for skin protection from oxidative damage
Ebau, F., Scano, A., Manca, M. L., Manconi, M., Cabras, V., Pilloni, M., & Ennas, G. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37462 · Cited by 12
Fabrication and characterization of tailor-made novel electrospun fibrous polyurethane scaffolds decorated with propolis and neem oil for tissue engineering applications
Jaganathan, S. K., Mani, M. P., Rathanasamy, R., & Prabhakaran, P. (2018) · Journal of Industrial Textiles · doi:10.1177/1528083718808787 · Cited by 12
Evaluation of Burn Wound Healing Efficacy and Biocompatibility of Centella asiatica Mediated Synthesised AgNPs Loaded Hybrid Nanofiber Scaffold: In Vitro and In Vivo Studies
Bozkaya, O., Bozkaya, E., Ekici, H., et al. (2024) · Macromolecular Materials and Engineering · doi:10.1002/mame.202400186 · Cited by 10
Nurturing hope: Uncovering the potential of herbal remedies against amyotrophic lateral sclerosis
Gupta, M., Hussain, M. S., Thapa, R., Bhat, A. A., & Kumar, N. (2024) · PharmaNutrition · doi:10.1016/j.phanu.2024.100406 · Cited by 10
Mechanisms of Sensitive Skin and the Soothing Effects of Active Compounds: A Review
Chen, B., Tang, H., Liu, Z., Qiao, K., Chen, X., Liu, S., Pan, N., Chen, T., & Liu, Z. (2024) · Cosmetics · doi:10.3390/cosmetics11060190 · Cited by 14
UHPLC–Q-ToF-MS-guided enrichment and purification of triterpenoids from Centella asiatica (L.) extract with macroporous resin
., A. I. C. D., Peter, G., Jude, S., Arundhathy, C. A., Jacob, J., Amalraj, A., Pius, A., & Gopi, S. (2017) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2017.1280681 · Cited by 10
“Asiaticoside (C48H78O19) was reported to induce changes in the expression of genes responsible for the synthesis of type-I collagen in human fibroblasts,([13,14]) whereas madecassoside (C48H78O20), possess a significant antirheumatoid effect, wound-healing properties, antiaging, and anticancer properties.([15,16]) Sev…”
Background
Medicinal plants used for cutaneous wound healing in Uganda; ethnomedicinal reports and pharmacological evidences
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“Reported mechanisms of action through which these medicinal plants exerted their wound healing activities comprise anti-oxidative activities [96 – 99], anti-inflammatory and immunomodulatory effects [100 – 103], antimicrobial effects [104 – 107], collagen synthesis [95,101,108], cell proliferation…”
Background
Evaluation of the cutaneous wound healing potential of tamanu oil in wounds induced in rats
Erdoğan, S. S., Gür, T. F., Terzi, N. K., & Doğan, B. (2021) · Journal of Wound Care · doi:10.12968/jowc.2021.30.sup9a.v · Cited by 8
Triterpenoid Centellosides: Bioactivities and Uses in Healthcare Application
Hashim, P. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_167 · Cited by 9
“Oral intake of MA, the major triterpenoid centelloside of CA, at 6, 12, and 24 mg kg 1 was seen to speed up the healing of burn wound in a timedependent manner due to the involvement of several mechanisms such as antioxidative activity, collagen synthesis, and angiogenesis [35].”
Background
Proangiogenic Potential of Medicinal Plants in Wound Healing
Kasote, D. M., Ahmad, A., & Viljoen, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800874-4.00006-4 · Cited by 9
Centella Asiatica Extract Containing Bilayered Electrospun Wound Dressing
İşoğlu, İ. A., & Koc, N. (2020) · Fibers and Polymers · doi:10.1007/s12221-020-9956-y · Cited by 8
Design of bio-scaffold conjugated with chitosan-PEG nano-carriers containing bio-macromolecules of Verbascum sinuatum L. to differentiate human adipose-derived stem cells into dermal keratinocytes
Amiri, M. S., Ghadi, A., & Baei, M. S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127520 · Cited by 7
Fine Wrinkle Improvement through Bioactive Materials That Modulate EDAR and BNC2 Gene Expression
Lee, S., Ye, S., Kim, M., Lee, H., Jun, S., & Kang, N. G. (2024) · Biomolecules · doi:10.3390/biom14030279 · Cited by 7
“Because several studies reported the role of madecassoside in fibroblasts [49,50], excellent efficacy was expected; however, we found that its treatment did not result in a statistically significant increase in gene expression (Figure 4c).”
Background
Novel Approaches for the Application of Herbs for Skin Care
Gautam, R. K., Kamal, M. A., Chopra, H., Tsagkaris, C., & Matthews, L. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023666220411110358 · Cited by 7
Aktivitas pegagan (Centella asiatica) pada dermatologi
Fernenda, L., Ramadani, A. P., & Syukri, Y. (2023) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.9.3.237-244.2022 · Cited by 14
Safety and efficacy of a class II medical device based on highly purified and standardized plant extracts in the management of post-menopausal patients with vulvar and vaginal atrophy: a single-center prospective observational study
Galli, V., D’Augè, T. G., Pierro, F. D., et al. (2024) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.23.05409-x · Cited by 6
Centella asiatica (L.) Urb. and Hydrocotyle umbellata L. identification and quality assessment: A methodology comparison
Noppradit, B., Klinnawee, L., Leeratiwong, C., Praparatana, R., & Puttarak, P. (2024) · Phytochemical Analysis · doi:10.1002/pca.3371 · Cited by 6
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Salgaonkar, S. P., Purewal, J. S., Doshi, G., Fernandes, T., Gharat, S., & Sawarkar, S. P. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128330298240708110336 · Cited by 6

Authors: Liu, M., Dai, Y., Li, Y., Luo, Y., Huang, F., Gong, Z., & Meng, Q.
Affiliations: China Pharmaceutical University (CN)
Nanjing Normal University (CN)
ORCID: Liu, Mei
Dai, Yue
Li, Ying
Luo, Yubin
Huang, Fang
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 2008-06
Volume: 74
Issue: 08
Pages: 809-815
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2008-1074533
OpenAlex: W1989354404
Cited by: 142
References: 0
Citations by year: 2026: 7 · 2025: 7 · 2024: 20 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 6 · 2013: 5 · 2012: 4
FWCI: 3.56
Type: journal article
Language: en
Open access: closed
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
Keywords: madecassoside, Centella asiatica, burn wound healing, triterpenoids, angiogenesis, re-epithelialization, fibroblast proliferation, oxidative stress, antioxidant activity, collagen synthesis, nitric oxide, malondialdehyde, reduced glutathione, hydroxyproline, endothelial cell growth, anti-inflammatory activity
MeSH terms: Animals, Burns, Collagen, Male, Phytotherapy, Mice, Inbred ICR, Triterpenes, Wound Healing, Lipid Peroxidation, Neovascularization, Physiologic, Centella, Mice

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Madecassoside Isolated from Centella asiatica Herbs Facilitates Burn Wound Healing in Mice

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