Cited by 10Artificial Intelligence in Healthcare and EducationEthics and Social Impacts of AIElectronic Health Records Systems

Why and How to Monitor Deployed AI Systems in Health Care

Keyes, Timothy, Callahan, Alison, Pandya, Abby S., Ambers, Nerissa, Banda, Juan M., Fuentes, Miguel, Lugtu, Carlene, Masariya, Pranav +13 more·2026·NEJM Catalyst

Abstract

Postdeployment monitoring of artificial intelligence (AI) systems in health care is essential to ensure their safety, quality, and sustained benefit - and to support governance decisions about which systems to update, modify, or decommission. Motivated by these needs, the authors developed a framework for monitoring deployed AI systems organized around three complementary principles: system integrity, performance, and impact. System integrity monitoring focuses on maximizing system uptime, detecting runtime errors, and identifying when changes to the surrounding information technology ecosystem have unintended effects. Performance monitoring focuses on maintaining accurate and equitable system behavior in the face of changing health care practices (and thus input data) over time. Impact monitoring assesses whether a deployed system continues to have value in the form of benefit to clinicians, staff, and patients. Drawing on examples of deployed AI systems at their academic medical center, the authors provide practical guidance for creating monitoring plans based on these principles that specify which metrics to measure and at what cadence, who is responsible for acting when metrics change, and what concrete follow-up actions should be taken - for both traditional and generative AI. They also discuss challenges in implementing this framework, including the effort of monitoring for health systems with limited resources, and the difficulty of incorporating data-driven monitoring practices into complex organizations where conflicting priorities and definitions of success often coexist. This framework offers a starting point for health systems seeking to ensure that AI deployments remain safe and effective over time.

Integrity signals

Registry

Crossref · 10.1056/cat.25.0372

Cites

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Cites

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Research works printed but not linked: 3

  1. Winden TJ, Chen ES, Monsen KA, Wang Y, Melton GB. Evaluation of flowsheet documentation in the electronic health record for residence, living situation, and living conditions. AMIA Jt Summits Transl Sci Proc 2018;2018:236.
  2. Lazaridou A, Kuncoro A, Gribovskaya E, et al. Mind the gap: assessing temporal generalization in neural language models. Adv Neural Inf Process Syst 2021;34:29348-29363.
  3. Microsoft Corporation, Databricks. Azure Databricks. 2025.

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Authors
Keyes, T., Callahan, A., Pandya, A. S., Ambers, N., Banda, J. M., Fuentes, M., Lugtu, C., Masariya, P., Nallan, S., O’Brien, C., Wang, T., Alsentzer, E., Chen, J. H., Dash, D., Eisenberg, M. A., Garcia, P., Kotecha, N., Revri, A., Pfeffer, M. A., Shah, N. H., & Jain, S. S.
Affiliations
  • Stanford Health Care (US)
  • Stanford University (US)
  • Data Scientist, Stanford Health Care, Palo Alto, CA, USA
  • Stanford Medicine (US)
  • Associate Chief Medical Information Officer, Stanford Health Care, Palo Alto, CA, USA
Venue
NEJM Catalyst
Published
2026-05-20
Volume
7
Issue
6
Pages
CAT250372-CAT250372
ISSN
2642-0007 (ISSN-L)
OpenAlex
W7161850328
Cited by
10
References
28
Citations by year
2026: 10
FWCI
19.45
Type
journal article
Language
en
Open access
closed
Locations
  • NEJM Catalyst (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Social Sciences › Safety Research › Ethics and Social Impacts of AI
  • Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
Keywords
post-deployment monitoring, artificial intelligence in healthcare, AI governance, performance monitoring, impact monitoring, generative AI, AI safety, AI equity, monitoring indicators, health system resources
MeSH terms
Intelligent Systems, Artificial Intelligence, Delivery of Health Care, Humans

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