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Continuous vs. Discontinuous Therapy with Penicillin: The Effect of the Interval between Injections on Therapeutic Efficacy
Abstract
THERE is a considerable body of experimental evidence that the therapeutic action of penicillin rests in large part on its direct bactericidal action, and that the factor that primarily determines its therapeutic efficacy is the total time for which the drug remains at effective levels at the focus of infection.1 2 3 4 Thus, the number of streptococci or pneumococci surviving in an intramuscular focus in mice after an injection of aqueous sodium penicillin G was found to decrease rapidly only so long as the penicillin remained at effective levels.3 , 4 Extremely large doses, providing concentrations greatly in excess of the effective level, were . . .
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Citations
Cited by
Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'
Drusano, G. L. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro862 · Cited by 930
Correlation of Antimicrobial Pharmacokinetic Parameters with Therapeutic Efficacy in an Animal Model
Vogelman, B., Gudmundsson, S., Leggett, J., Turnidge, J., Ebert, S., & Craig, W. A. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.4.831 · Cited by 720
Ambrose, P. G., Bhavnani, S. M., Rubino, C. M., Louie, A., Gumbo, T., Forrest, A., & Drusano, G. L. (2007) · Clinical Infectious Diseases · doi:10.1086/510079 · Cited by 697
Pharmacokinetic-Pharmacodynamic Modeling of Antibacterial Drugs
Nielsen, E. I., & Friberg, L. E. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005769 · Cited by 332
Ambrose, P. G., Grasela, D. M., Grasela, T. H., Passarell, J., Mayer, H. B., & Pierce, P. F. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2793-2797.2001 · Cited by 299
Metadata
- Authors
- Eagle, H., Fleischman, R., & Levy, M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1953-03-19
- Volume
- 248
- Issue
- 12
- Pages
- 481-488
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2048047136
- Cited by
- 230
- References
- 0
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Continuous vs. Discontinuous Therapy with Penicillin: The Effect of the Interval between Injections on Therapeutic Efficacy. https://app.cochat.ai/papers/10.1056/nejm195303192481201
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- Eagle, H., Fleischman, R., & Levy, M. (1953). Continuous vs. Discontinuous Therapy with Penicillin: The Effect of the Interval between Injections on Therapeutic Efficacy. New England Journal of Medicine. https://doi.org/10.1056/nejm195303192481201
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
