Antimicrobial Resistance: Pharmacokinetics‐Pharmacodynamics of Antimicrobial Therapy: It’s Not Just for Mice Anymore
Abstract
Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal infection models have allowed for the in vivo evaluation of antimicrobial agents for the treatment of experimentally induced infection. Today, animal pharmacokinetic-pharmacodynamic (PK-PD) infection models serve as a cornerstone of the preclinical assessment process for antibacterial agents and dose and dosing interval selection, as decision support for setting in vitro susceptibility breakpoints, and, finally, for the evaluation of the meaning of in vitro resistance. Over the past 15 years, considerable PK-PD data have been derived from infected patients for many classes of antimicrobial agents. These data provide the opportunity to confirm knowledge gained from animal PK-PD infection models.
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Studies with fluoroquinolone antibacterials identified an AUC/MIC target for Streptococcus pneumoniae of 25, whereas for gram-negative bacteria the value was near 100.
“For example, studies with fluoroquinolone antibacterials identified an AUC/MIC target for Streptococcus pneumoniae of 25, whereas for gram-negative bacteria the value was near 100.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [166]
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- Authors
- Ambrose, P. G., Bhavnani, S. M., Rubino, C. M., Louie, A., Gumbo, T., Forrest, A., & Drusano, G. L.
- Affiliations
- Institute for Clinical Pharmacodynamics (United States) (US)
- Corresponding author
- Ambrose, Paul G.
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01
- Volume
- 44
- Issue
- 1
- Pages
- 79-86
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2150760368
- Cited by
- 697
- References
- 33
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 32 · 2023: 32 · 2022: 39 · 2021: 34 · 2020: 34 · 2019: 27 · 2018: 43 · 2017: 48 · 2016: 38 · 2015: 36 · 2014: 41 · 2013: 48 · 2012: 35
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- antimicrobial resistance, pharmacokinetics/pharmacodynamics, animal models of infection, susceptibility breakpoints, in vitro resistance, experimental infection
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacterial Infections, Disease Models, Animal, Humans, Respiratory Tract Infections, Bacteremia, Skin Diseases, Bacterial, Community-Acquired Infections, Area Under Curve, Mice
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