Advances in the Diagnosis of Altered States of Adrenocortical Function

Laidlaw, John C.; Reddy, William J.; Jenkins, Dalton; Haydar, Najib Abu; Renold, Albert E.; Thorn, George W.

doi:10.1056/nejm195511032531801

Cited by 82Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

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Advances in the Diagnosis of Altered States of Adrenocortical Function

Laidlaw, John C., Reddy, William J., Jenkins, Dalton, Haydar, Najib Abu, Renold, Albert E., Thorn, George W.·1955·New England Journal of Medicine

DOI 10.1056/nejm195511032531801

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Abstract

GREAT advances in the diagnosis of altered states of adrenocortical function have been made possible by improvements in methods of steroid analysis and by the availability of purified preparations of ACTH and adrenocortical hormones. The development of simple methods for the measurement of blood and urinary 17-hydroxycorticoids has facilitated the estimation of the quantity of hydrocortisone secreted by the human adrenal cortex.1 , 2 The availability of ACTH has opened the way to the exploration of adrenocortical reserve in a wide variety of physiologic and pathologic states. It now appears that the intravenous administration of ACTH with the determination of 17-hydroxycorticoids and . . .

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The loss of circadian rhythm with the absence of a late-night cortisol nadir is a hallmark biochemical abnormality in patients with CS.
“The loss of circadian rhythm with the absence of a late-night cortisol nadir is a hallmark biochemical abnormality in patients with CS (11, 25, 26).”
From Measuring cortisol in Cushing syndrome: diagnosis, monitoring, and cortisol circadian rhythm improvement. (2026) · cites this paper as [25]

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Cortisol salivar noturno no diagnóstico de recidiva em pacientes com Doença de Cushing operados
Alexandre, A. E. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2024.tde-20022025-134110

Authors: Laidlaw, J. C., Reddy, W. J., Jenkins, D., Haydar, N. A., Renold, A. E., & Thorn, G. W.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1955-11-03
Volume: 253
Issue: 18
Pages: 747-753
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm195511032531801
OpenAlex: W2003021259
Cited by: 82
References: 19
Citations by year: 2026: 1 · 2018: 1
FWCI: 14.93
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: adrenocortical function, adrenal insufficiency, ACTH stimulation test, 17-hydroxycorticosteroids, cortisol, adrenocortical reserve, steroid analysis, urinary steroids, adrenal cortex
MeSH terms: Adrenal Cortex, Adrenal Cortex Function Tests, Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Body Fluids, Humans, Steroids, Urine

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Advances in the Diagnosis of Altered States of Adrenocortical Function

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