The DOI matches its Crossref record.
Metalloenzymes and Myocardial Infarction: Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum
Abstract
PREVIOUS studies in this laboratory have shown that the concentration of copper in serum is considerably increased after acute myocardial infarction.1 This change is proportional to an increase in ceruloplasmin, the copper protein of human serum, and its capacity to oxidize paraphenylenediamine.2 In the pursuit of these studies, the concentration of zinc and the activity of zinc enzymes in human serum have been found to be altered markedly in myocardial necrosis.Lactic dehydrogenase has recently been shown to be a zinc enzyme,3 and malic dehydrogenase also appears to be a metalloenzyme.4 These enzymes require coenzyme 1 (diphosphopyridine nucleotide) for their . . .
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Citations
Cited by
Goldstein, I. M., Roos, D., Kaplan, H. B., & Weissmann, G. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108191 · Cited by 746
Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686
Thompson, C. B., Eaton, K. A., Princiotta, S. M., Rushin, C. A., & Valeri, C. R. (1982) · British Journal of Haematology · doi:10.1111/j.1365-2141.1982.tb01947.x · Cited by 375
Metadata
- Authors
- Wacker, W. E. C., Ulmer, D. D., & Vallee, B. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1956-09-06
- Volume
- 255
- Issue
- 10
- Pages
- 449-456
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3154367256
- Cited by
- 655
- References
- 0
- FWCI
- 18.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Metalloenzymes and Myocardial Infarction: Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum. https://app.cochat.ai/papers/10.1056/nejm195609062551001
- The paper
- Wacker, W. E. C., Ulmer, D. D., & Vallee, B. L. (1956). Metalloenzymes and Myocardial Infarction: Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum. New England Journal of Medicine. https://doi.org/10.1056/nejm195609062551001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
