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Myocardial Norepinephrine Concentration in Man: Effects of Reserpine and of Congestive Heart Failure
Abstract
THE rauwolfia alkaloids have been widely used in clinical practice, but relatively little information concerning the mechanism of their circulatory action in man is available. Reserpine has been extensively studied in laboratory animals, and it has been demonstrated that after the parenteral administration of relatively large doses of this drug, postganglionic sympathetic nerves are no longer able to transmit impulses across the neuroeffector junctions.1 Also, in animals, a profound fall in the concentration of norepinephrine, epinephrine and serotonin throughout the body occurs after reserpine administration,2 3 4 and the sympathetic blockade produced by reserpine in laboratory animals has been attributed to the . . .
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Citations
Cited by
Cohn, J. N., Ferrari, R., & Sharpe, N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00630-0 · Cited by 2,161
Dobutamine: development of a new catecholamine to selectively increase cardiac contractility.
Tuttle, R. R., & Mills, J. (1975) · Circulation Research · doi:10.1161/01.res.36.1.185 · Cited by 619
The Neurohumoral Axis in Congestive Heart Failure
FRANCIS, G. S., GOLDSMITH, S. R., LEVINE, T. B., OLIVARI, M. T., & COHN, J. N. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-370 · Cited by 600
The Autonomic Nervous System and Heart Failure
Florea, V. G., & Cohn, J. N. (2014) · Circulation Research · doi:10.1161/circresaha.114.302589 · Cited by 572
The human sympathetic nervous system: its relevance in hypertension and heart failure
Parati, G., & Esler, M. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs041 · Cited by 538
Metadata
- Authors
- Chidsey, C. A., Braunwald, E., Morrow, A. G., & Mason, D. T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1963-09-26
- Volume
- 269
- Issue
- 13
- Pages
- 653-658
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2335953854
- Cited by
- 271
- References
- 0
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chidsey, C. A., Braunwald, E., Morrow, A. G., & Mason, D. T. (1963). Myocardial Norepinephrine Concentration in Man: Effects of Reserpine and of Congestive Heart Failure. New England Journal of Medicine. https://doi.org/10.1056/nejm196309262691302
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
