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Aromatic Amino Acids and Modification of Parkinsonism
Abstract
THE known biochemical abnormalities in Parkinson's disease consist of a decrease of melanin pigment in the substantia nigra1 , 2 and a decrease of some biogenic amines in the substantia nigra and the corpus striatum.3 These 2 defects might be interrelated, as suggested by the fact that in both melanocytes4 and sympathetic cells5 tyrosine is hydroxylated to dihydroxyphenylalanine, a common precursor in the synthesis of both melanin and catecholamines. Furthermore, both melanocytes and sympathetic cells originate from the neural crest.6 It was suggested earlier7 , 8 that the interrelations between melanogenesis and extrapyramidal disease might be of fundamental importance. It was noted that chronic . . .
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Citations
Cited by
Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
Freed, C. R., Greene, P. E., Breeze, R. E., Tsai, W.-Y., DuMouchel, W., Kao, R., Dillon, S., Winfield, H., Culver, S., Trojanowski, J. Q., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441002 · Cited by 2,366
Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.242 · Cited by 1,190
Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859
Classification of suicidal behaviors: I. Quantifying intent and medical lethality
(1975) · American Journal of Psychiatry · doi:10.1176/ajp.132.3.285 · Cited by 460
Imaging endogenous dopamine competition with [11C]raclopride in the human brain
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Angrist, B., Pappas, N., MacGregor, R., et al. (1994) · Synapse · doi:10.1002/syn.890160402 · Cited by 379
Metadata
- Authors
- Cotzias, G. C., Van Woert, M. H., & Schiffer, L. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1967-02-16
- Volume
- 276
- Issue
- 7
- Pages
- 374-379
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337142316
- Cited by
- 1,494
- References
- 0
- FWCI
- 99.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cotzias, G. C., Van Woert, M. H., & Schiffer, L. M. (1967). Aromatic Amino Acids and Modification of Parkinsonism. New England Journal of Medicine. https://doi.org/10.1056/nejm196702162760703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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