Cited by 1,190Parkinson's Disease Mechanisms and TreatmentsNeurology and Historical StudiesNeurological disorders and treatments

100 years of Lewy pathology

Goedert, Michel, Spillantini, Maria Grazia, Del Tredici, Kelly, Braak, Heiko·2013·Nature Reviews Neurology

Abstract

In 1817, James Parkinson described the symptoms of the shaking palsy, a disease that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin Charcot. Parkinson expected that the publication of his monograph would lead to a rapid elucidation of the anatomical substrate of the shaking palsy; in the event, this process took almost a century. In 1912, Fritz Heinrich Lewy identified the protein aggregates that define Parkinson disease (PD) in some brain regions outside the substantia nigra. In 1919, Konstantin Nikolaevich Tretiakoff found similar aggregates in the substantia nigra and named them after Lewy. In the 1990s, α-synuclein was identified as the main constituent of the Lewy pathology, and its aggregation was shown to be central to PD, dementia with Lewy bodies, and multiple system atrophy. In 2003, a staging scheme for idiopathic PD was introduced, according to which α-synuclein pathology originates in the dorsal motor nucleus of the vagal nerve and progresses from there to other brain regions, including the substantia nigra. In this article, we review the relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders.

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Crossref · 10.1038/nrneurol.2012.242

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Authors
Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H.
Affiliations
  • MRC Laboratory of Molecular Biology (GB)
  • University of Cambridge (GB)
  • Universität Ulm (DE)
Corresponding author
Goedert, Michel
Venue
Nature Reviews Neurology
Published
2012-11-27
Volume
9
Issue
1
Pages
13-24
ISSN
  • 1759-4758 (ISSN-L)
  • 1759-4766
OpenAlex
W2089522371
Cited by
1,190
References
166
Citations by year
2026: 65 · 2025: 77 · 2024: 94 · 2023: 96 · 2022: 105 · 2021: 113 · 2020: 124 · 2019: 100 · 2018: 78 · 2017: 90 · 2016: 86 · 2015: 60 · 2014: 56 · 2013: 45
FWCI
7.21
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Parkinson's UK (G-1102, K-1012)
  • Research Councils UK
  • Deutsche Forschungsgemeinschaft
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Lewy body pathology, Parkinson's disease, alpha-synuclein aggregation, Lewy bodies, dementia with Lewy bodies, multiple system atrophy, substantia nigra, neurodegeneration
MeSH terms
Brain, Germany, Humans, Parkinson Disease, Multiple System Atrophy, Lewy Body Disease, History, 19th Century, History, 20th Century, History, 21st Century, alpha-Synuclein

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