100 years of Lewy pathology
Abstract
In 1817, James Parkinson described the symptoms of the shaking palsy, a disease that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin Charcot. Parkinson expected that the publication of his monograph would lead to a rapid elucidation of the anatomical substrate of the shaking palsy; in the event, this process took almost a century. In 1912, Fritz Heinrich Lewy identified the protein aggregates that define Parkinson disease (PD) in some brain regions outside the substantia nigra. In 1919, Konstantin Nikolaevich Tretiakoff found similar aggregates in the substantia nigra and named them after Lewy. In the 1990s, α-synuclein was identified as the main constituent of the Lewy pathology, and its aggregation was shown to be central to PD, dementia with Lewy bodies, and multiple system atrophy. In 2003, a staging scheme for idiopathic PD was introduced, according to which α-synuclein pathology originates in the dorsal motor nucleus of the vagal nerve and progresses from there to other brain regions, including the substantia nigra. In this article, we review the relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders.
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Co-occurrence of different disease-associated protein aggregates is frequently observed in human neurodegenerative diseases.
“the co‐occurrence of different disease‐associated protein aggregates is frequently observed in human neurodegenerative diseases.”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [173]
Aβ plaques and NFTs are commonly detected in Parkinson's disease and DLB brains.
“Aβ plaques and NFTs are commonly detected in Parkinson's disease and DLB brains.”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [173]
Over 50% of AD patients exhibit Lewy bodies.
“over 50% of AD patients exhibit Lewy bodies”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [173]
Pathological hallmarks of PD include death of dopaminergic neurons of the substantia nigra pars compacta and intraneuronal accumulation of the α-synuclein protein.
“Pathological hallmarks of PD include death of dopaminergic neurons of the substantia nigra pars compacta and intraneuronal accumulation of the α-synuclein protein (Goedert et al., 2013).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Goedert et al., 2013
Cites
1 retracted
Masliah, E., Rockenstein, E. M., Mante, M., Crews, L. A., Spencer, B. J., Adame, A., Patrick, C., Trejo, M., Ubhi, K. K., Rohn, T. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019338 · Cited by 422 · see citing works
RetractedParkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107 · see citing works
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
Self-citationSpillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works
Self-citationMutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914 · see citing works
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works
Epidemiology of Parkinson's disease
de Lau, L. M., & Breteler, M. M. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70471-9 · Cited by 4,110 · see citing works
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836 · see citing works
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273 · see citing works
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6469 · Cited by 3,151 · see citing works
Self-citationMutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,024 · see citing works
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737 · see citing works
Parkinson, J. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.2.223 · Cited by 2,684 · see citing works
Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease
Paisán‐Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simón, J., van der Brug, M., de Munaín, A. L., Aparicio, S. F., Gil, A. M., Khan, N. L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.023 · Cited by 2,416 · see citing works
A Drosophila model of Parkinson's disease
Feany, M., & Bender, W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,145 · see citing works
Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
Sidransky, E., Nalls, M. A., Aasly, J. O., Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901281 · Cited by 2,135 · see citing works
α-synuclein locus duplication as a cause of familial Parkinson's disease
Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029 · see citing works
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Simón‐Sánchez, J., Schulte, C., Brás, J., Sharma, M., Gibbs, J. R., Berg, D., Paisán‐Ruiz, C., Lichtner, P., Scholz, S. W., Hernandez, D. G., et al. (2009) · Nature Genetics · doi:10.1038/ng.487 · Cited by 1,916 · see citing works
α-Synuclein is phosphorylated in synucleinopathy lesions
Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M., Shen, J., Takio, K., & Iwatsubo, T. (2002) · Nature Cell Biology · doi:10.1038/ncb748 · Cited by 1,906 · see citing works
Ehringer, H., & Hornykiewicz, O. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01485901 · Cited by 1,875 · see citing works
Li, J.-Y., Englund, E., Holton, J. L., Soulet, D., Hagell, P., Lees, A. J., Lashley, T., Quinn, N. P., Rehncrona, S., Björklund, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1746 · Cited by 1,845 · see citing works
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works
Masliah, E., Rockenstein, E. M., Veinbergs, I., Mallory, M. E., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., & Mucke, L. (2000) · Science · doi:10.1126/science.287.5456.1265 · Cited by 1,763 · see citing works
Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W. (2008) · Nature Medicine · doi:10.1038/nm1747 · Cited by 1,722 · see citing works
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722 · see citing works
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works
Volpicelli-Daley, L. A., Luk, K. C., Patel, T. P., Tanik, S. A., Riddle, D. M., Stieber, A., Meaney, D. F., Trojanowski, J. Q., & Lee, V. M.-Y. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.033 · Cited by 1,569 · see citing works
Aromatic amino acids and modification of parkinsonism.
Cotzias, G., van Woert, M. H., & Schiffer, L. (1967) · New England Journal of Medicine · doi:10.1056/nejm196702162760703 · Cited by 1,501 · see citing works
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Desplats, P., Lee, H.-J., Bae, E.-J., Patrick, C., Rockenstein, E., Crews, L., Spencer, B., Masliah, E., & Lee, S.-J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903691106 · Cited by 1,485 · see citing works
Anderson, J. P., Walker, D., Goldstein, J. M., de Laat, R., Banducci, K., Caccavello, R. J., Barbour, R., Huang, J., Kling, K., Lee, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600933200 · Cited by 1,418 · see citing works
Alpha-synuclein and neurodegenerative diseases
Goedert, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081564 · Cited by 1,402 · see citing works
Self-citationBenabid, A., Pollak, P., Louveau, A., Henry, S., & de Rougemont, J. (1987) · Stereotactic and Functional Neurosurgery · doi:10.1159/000100803 · Cited by 1,387 · see citing works
Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works
Self-citationSatake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.485 · Cited by 1,308 · see citing works
Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., & Lee, V. M.-Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00682-7 · Cited by 1,266 · see citing works
Chaperone Suppression of α-Synuclein Toxicity in a <i>Drosophila</i> Model for Parkinson's Disease
Auluck, P. K., Chan, H. Y. E., Trojanowski, J. Q., Lee, V. M.-Y., & Bonini, N. M. (2002) · Science · doi:10.1126/science.1067389 · Cited by 1,227 · see citing works
Travis, W. D., Castile, R. G., Vawter, G. F., Shwachman, H., Warwick, W. J., Burke, B. A., & Skinner, M. M. (1986) · American Journal of Clinical Pathology · doi:10.1093/ajcp/85.4.419 · Cited by 1,189 · see citing works
Chronic Behavioral Disorders of Human REM Sleep: A New Category of Parasomnia
Schenck, C. H., Bundlie, S. R., Ettinger, M. G., & Mahowald, M. W. (1986) · SLEEP · doi:10.1093/sleep/9.2.293 · Cited by 1,156 · see citing works
Canet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115 · see citing works
Luk, K. C., Kehm, V. M., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M. ‐. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112457 · Cited by 1,087 · see citing works
Causal relation between α-synuclein locus duplication as a cause of familial Parkinson's disease
Ibáñez, P., Bonnet, A. M., Débarges, B., Lohmann, E., Tison, F., Agid, Y., Dürr, A., Brice, A., & Pollak, P. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17104-3 · Cited by 1,042 · see citing works
Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., & Goedert, M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00504-7 · Cited by 1,026 · see citing works
Self-citationZarow, C., Lyness, S. A., Mortimer, J. A., & Chui, H. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.337 · Cited by 1,003 · see citing works
Papp, M. I., Kahn, J. E., & Lantos, P. L. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90219-0 · Cited by 991 · see citing works
Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972 · see citing works
Self-citationKondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., et al. (2012) · Open Biology · doi:10.1098/rsob.120080 · Cited by 940 · see citing works
Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
Cremades, N., Cohen, S. I. A., Deas, E., Abramov, A. Y., Chen, A. Y., Orte, Á., Sandal, M., Clarke, R. W., Dunne, P., Aprile, F. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.037 · Cited by 901 · see citing works
Hansen, C., Angot, E., Bergström, A.-L., Steiner, J. A., Pieri, L., Paul, G., Outeiro, T. F., Melki, R., Kallunki, P., Fog, K., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43366 · Cited by 842 · see citing works
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
Serpell, L. C., Berriman, J. A., Jakes, R., Goedert, M., & Crowther, R. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4897 · Cited by 748 · see citing works
Self-citationKirik, D., Rosenblad, C., Bürger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., Mandel, R. J., & Björklund, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02780.2002 · Cited by 730 · see citing works
Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L. I., Myers, R. H., Lindquist, S., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.019 · Cited by 728 · see citing works
the Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Lue, L., Sue, L. I., Bachalakuri, J., Henry-Watson, J., Sasse, J., Boyer, S., Shirohi, S., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0538-8 · Cited by 698 · see citing works
Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. ‐. (1998) · Annals of Neurology · doi:10.1002/ana.410440324 · Cited by 686 · see citing works
Pathology of Parkinson’s disease
Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 682 · see citing works
α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
Wakabayashi, K., Yoshimoto, M., Tsuji, S., & Takahashi, H. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00407-8 · Cited by 643 · see citing works
Braak, H., Bohl, J. R., Müller, C. M., Rüb, U., de Vos, R. A. I., & Del Tredici, K. (2006) · Movement Disorders · doi:10.1002/mds.21065 · Cited by 630 · see citing works
Self-citationA timeline for Parkinson's disease
Hawkes, C. H., Del Tredici, K., & Braak, H. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.08.007 · Cited by 594 · see citing works
Self-citationThe parkinson's complex: Parkinsonism is just the tip of the iceberg
Langston, J. W. (2006) · Annals of Neurology · doi:10.1002/ana.20834 · Cited by 585 · see citing works
Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease
Masliah, E., Rockenstein, E., Adame, A., Alford, M., Crews, L., Hashimoto, M., Seubert, P., Lee, M., Goldstein, J., Chilcote, T., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.010 · Cited by 542 · see citing works
The fold of α-synuclein fibrils
Vilar, M., Chou, H., Lührs, T., Maji, S. K., Riek-Loher, D., Verel, R., Manning, G., Stahlberg, H., & Riek, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712179105 · Cited by 539 · see citing works
Bianco, C. L., Ridet, J.-L., Schneider, B. L., Déglon, N., & Aebischer, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152339799 · Cited by 533 · see citing works
[The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].
Birkmayer, W., & Hornykiewicz, O. (1961) · PubMed · Cited by 529 · see citing works
Pan-Montojo, F., Anichtchik, O., Dening, Y., Knels, L., Pursche, S., Jung, R., Jackson, S., Gille, G., Spillantini, M. G., Reichmann, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008762 · Cited by 524 · see citing works
Self-citationA Unifying Role for Prions in Neurodegenerative Diseases
Prusiner, S. B. (2012) · Science · doi:10.1126/science.1222951 · Cited by 495 · see citing works
Parkinson’s disease induced pluripotent stem cells with triplication of the α-synuclein locus
Devine, M. J., Ryten, M., Vodicka, P., Thomson, A. J., Burdon, T., Houlden, H., Cavaleri, F., Nagano, M., Drummond, N. J., Taanman, J.-W., et al. (2011) · Nature Communications · doi:10.1038/ncomms1453 · Cited by 486 · see citing works
Shults, C. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509567103 · Cited by 476 · see citing works
Is alpha-synuclein in the colon a biomarker for premotor Parkinson’s disease? Evidence from 3 cases
Shannon, K. M., Keshavarzian, A., Dodiya, H. B., Jakate, S., & Kordower, J. H. (2012) · Movement Disorders · doi:10.1002/mds.25020 · Cited by 464 · see citing works
The propagation of prion-like protein inclusions in neurodegenerative diseases
Goedert, M., Clavaguera, F., & Tolnay, M. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.04.003 · Cited by 451 · see citing works
Self-citationNeuropathology of Autonomic Nervous System in Parkinson's Disease
Wakabayashi, K., & Takahashi, H. (2008) · European Neurology · doi:10.1159/000113469 · Cited by 407 · see citing works
Occurrence of Parkinson's syndrome in type 1 Gaucher disease
Neudorfer, O., Giladi, N., Elstein, D., Abrahamov, A., Turezkite, T., Aghai, E., Reches, A., Bembi, B., & Zimran, A. (1996) · QJM · doi:10.1093/qjmed/89.9.691 · Cited by 401 · see citing works
Lakso, M., Vartiainen, S., Moilanen, A., Sirviö, J., Thomas, J. H., Nass, R., Blakely, R., & Wong, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01809.x · Cited by 398 · see citing works
Olfactory function in patients with Parkinson's disease
Ansari, K. A., & Johnson, A. (1975) · Journal of Chronic Diseases · doi:10.1016/0021-9681(75)90058-2 · Cited by 375 · see citing works
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
Mougenot, A.-L. J., Nicot, S., Bencsik, A. A., Morignat, E., Verchère, J., Lakhdar, L., Legastelois, S., & Baron, T. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.022 · Cited by 375 · see citing works
Bradbury, S., & EGGLESTON, C. (1925) · American Heart Journal · doi:10.1016/s0002-8703(25)90007-5 · Cited by 373 · see citing works
Small Molecule Inhibitors of α-Synuclein Filament Assembly
Masuda, M., Suzuki, N., Taniguchi, S., Oikawa, T., Nonaka, T., Iwatsubo, T., Hisanaga, S., Goedert, M., & Hasegawa, M. (2006) · Biochemistry · doi:10.1021/bi0600749 · Cited by 367 · see citing works
Self-citationEvidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364 · see citing works
Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of α-Synucleinopathy
Uchikado, H., Lin, W.-L., DeLucia, M. W., & Dickson, D. W. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000225908.90052.07 · Cited by 359 · see citing works
Duffy, P. E., & Tennyson, V. M. (1965) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196507000-00003 · Cited by 351 · see citing works
Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough
Lang, A. E., & Obeso, J. A. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00740-9 · Cited by 346 · see citing works
Bloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 330 · see citing works
Tofaris, G. K., Garcia-Reitboeck, P., Humby, T., Lambourne, S. L., O’Connell, M. T., Ghetti, B. F., Gossage, H., Emson, P. C., Wilkinson, L. S., Goedert, M., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4965-05.2006 · Cited by 325 · see citing works
Self-citationBraak, H., Sastre, M., Böhl, J., de Vos, R. A. I., & Tredici, K. D. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0193-x · Cited by 320 · see citing works
Self-citationWakabayashi, K., Takahashi, H., Ohama, E., & Ikuta, F. (1990) · Acta Neuropathologica · doi:10.1007/bf00294234 · Cited by 319 · see citing works
The neuropathology of genetic Parkinson's disease
Poulopoulos, M., Levy, O. A., & Alcalay, R. N. (2012) · Movement Disorders · doi:10.1002/mds.24962 · Cited by 306 · see citing works
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
Greten-Harrison, B., Polydoro, M., Morimoto‐Tomita, M., Diao, L., Williams, A. M., Nie, E. H., Makani, S., Tian, N., Castillo, P. E., Buchman, V. L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005005107 · Cited by 305 · see citing works
Esophageal Lewy bodies associated with ganglion cell loss in achalasia
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90079-9 · Cited by 305 · see citing works
Neuroanatomy and Pathology of Sporadic Parkinson's Disease
Braak, H., & Tredici, K. D. (2008) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-540-79850-7 · Cited by 297 · see citing works
Self-citationAmygdala pathology in Parkinson's disease
Braak, H., Braak, E., Yilmazer‐Hanke, D., de Vos, R. A. I., Jansen, E. N. H., Böhl, J., & Jellinger, K. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00296485 · Cited by 297 · see citing works
Self-citationQualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · PubMed · Cited by 295 · see citing works
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
Garcia-Reitboeck, P., Anichtchik, O. V., Bellucci, A., Iovino, M., Ballini, C., Fineberg, E., Ghetti, B. F., Corte, L., Spano, P., Tofaris, G. K., et al. (2010) · Brain · doi:10.1093/brain/awq132 · Cited by 293 · see citing works
Self-citationTredici, K. D., Hawkes, C. H., Ghebremedhin, E., & Braak, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0665-2 · Cited by 292 · see citing works
Self-citationMorphogenesis of Lewy Bodies: Dissimilar Incorporation of α-Synuclein, Ubiquitin, and p62
Kuusisto, E., Parkkinen, L., & Alafuzoff, I. I. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1241 · Cited by 291 · see citing works
Aggregated α-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo
Periquet, M., Fulga, T. A., Myllykangas, L., Schlossmacher, M. G., & Feany, M. Β. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0285-07.2007 · Cited by 291 · see citing works
Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works
SNCA variants are associated with increased risk for multiple system atrophy
Scholz, S. W., Houlden, H., Schulte, C., Sharma, M., Li, A., Berg, D., Melchers, A., Paudel, R., Gibbs, J. R., Simón‐Sánchez, J., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21685 · Cited by 280 · see citing works
Lewy body–type degeneration in cardiac plexus in Parkinson’s and incidental Lewy body diseases
Iwanaga, K., Wakabayashi, K., Yoshimoto, M., Tomita, I., Satoh, H., Takashima, H., Satoh, A., Seto, M., Tsujihata, M., & Takahashi, H. (1999) · Neurology · doi:10.1212/wnl.52.6.1269 · Cited by 274 · see citing works
Ross, O. A., Toft, M., Whittle, A. J., Johnson, J. L., Papapetropoulos, S., Mash, D. C., Litvan, I., Gordon, M. F., Wszołek, Z. K., Farrer, M. J., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20731 · Cited by 268 · see citing works
Neuropathology of non-motor features of Parkinson disease
Dickson, D. W., Fujishiro, H., Orr, C., DelleDonne, A., Josephs, K. A., Frigerio, R., Burnett, M. S., Parisi, J. E., Klos, K. J., & Ahlskog, J. E. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70769-2 · Cited by 267 · see citing works
Orimo, S., Amino, T., Itoh, Y., Takahashi, A., Kojo, T., Uchihara, T., Tsuchiya, K., Mori, F., Wakabayashi, K., & Takahashi, H. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-0995-7 · Cited by 264 · see citing works
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
Specht, C. G., & Schoepfer, R. (2001) · BMC Neuroscience · doi:10.1186/1471-2202-2-11 · Cited by 264 · see citing works
PINK1-linked parkinsonism is associated with Lewy body pathology
Samaranch, L., Lorenzo‐Betancor, O., Arbelo, J. M., Ferrer, I., Lorenzo, E., Irigoyen, J., Pastor, M. A., Marrero, C., Isla, C., Herrera-Henriquez, J., et al. (2010) · Brain · doi:10.1093/brain/awq051 · Cited by 256 · see citing works
Beitrag zur Histopathologie der myoklonischen Epilepsie
Lafora, G. R., & Glueck, B. (1911) · Zeitschrift für die gesamte Neurologie und Psychiatrie · doi:10.1007/bf02863929 · Cited by 233 · see citing works
Lindvall, C., & Lask, B. D. (2011) · Wiley eBooks · doi:10.1002/9781119998402.ch10 · Cited by 219 · see citing works
Li, J., Englund, E. M., Widner, H., Rehncrona, S., Björklund, A., Lindvall, O., & Brundin, P. (2010) · Movement Disorders · doi:10.1002/mds.23012 · Cited by 214 · see citing works
Overview of the Extranigral Aspects of Parkinson Disease
Lim, S., Fox, S. H., & Lang, A. E. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.561 · Cited by 207 · see citing works
Mulcahy, R., & Hickey, N. J. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91654-2 · Cited by 203 · see citing works
Lewy Body-Related α-Synucleinopathy in Aging
Saito, Y., Ruberu, N. N., Sawabe, M., Arai, T., Kazama, H., Hosoi, T., Yamanouchi, H., & Murayama, S. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.742 · Cited by 200 · see citing works
Molecular and clinical prodrome of Parkinson disease: implications for treatment
Schapira, A. H. V., & TOLOSA, E. S. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.52 · Cited by 199 · see citing works
Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy
Al‐Chalabi, A., Dürr, A., Wood, N. W., Parkinson, M. H., Camuzat, A., Hulot, J., Morrison, K. E., Renton, A. E., Sussmuth, S. D., Landwehrmeyer, G. B., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007114 · Cited by 197 · see citing works
Paralysis agitans. I. Pathologische Anatomie
Lewy, F. (1912) · Medical Entomology and Zoology · Cited by 194 · see citing works
Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss
Annerino, D. M., Arshad, S., Taylor, G. M., Adler, C., Beach, T., & Greene, J. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1040-2 · Cited by 185 · see citing works
Lewy, F. H. (1923) · Springer eBooks · Cited by 184 · see citing works
Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model
Lee, K.-W., Chen, W. W., Junn, E., Im, J., Grosso, H., Sonsalla, P. K., Feng, X., Ray, N., Fernandez, J. R., Chao, Y., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6513-10.2011 · Cited by 184 · see citing works
Lewy pathology and neurodegeneration in premotor Parkinson's disease
Tredici, K. D., & Braak, H. (2012) · Movement Disorders · doi:10.1002/mds.24921 · Cited by 184 · see citing works
Self-citationPathology associated with sporadic Parkinson’s disease — where does it end?
Braak, H., Müller, C. M., Rüb, U., Ackermann, H., Bratzke, H., de Vos, R. A. I., & Tredici, K. D. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_15 · Cited by 182 · see citing works
Self-citationGlucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders
Göker-Alpan, Ö., Stubblefield, B. K., Giasson, B. I., & Sidransky, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0741-7 · Cited by 179 · see citing works
Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study)
Reid, W., Hely, M. A., Morris, J. G., Loy, C., & Halliday, G. M. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.232678 · Cited by 179 · see citing works
Lewy Body Pathology in Alzheimer's Disease
Kotzbauer, P. T., Tojanowski, J. Q., & Lee, V. M. V. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:225 · Cited by 177 · see citing works
Burré, J., Sharma, M., & Südhof, T. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3545-12.2012 · Cited by 175 · see citing works
Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
Kordower, J. H., Dodiya, H. B., Kordower, A. M., Terpstra, B. T., Paumier, K. L., Madhavan, L., Sortwell, C. E., Steece‐Collier, K., & Collier, T. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.001 · Cited by 170 · see citing works
Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons
Saha, R. A., Hill, J. E., Utton, M. A., Asuni, A. A., Ackerley, S., Grierson, A. J., Miller, C. C. J., Davies, A. M., Buchman, V. L., Anderton, B. H., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.00967 · Cited by 170 · see citing works
Kuwahara, T., Koyama, A., Koyama, S., Yoshina, S., Ren, C.-H., Kato, T., Mitani, S., & Iwatsubo, T. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn198 · Cited by 166 · see citing works
Spinal cord lesions in sporadic Parkinson’s disease
Tredici, K. D., & Braak, H. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1028-y · Cited by 163 · see citing works
Self-citationα-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
McCormack, A. L., Mak, S. K., Henderson, J. M., Bumcrot, D. A., Farrer, M. J., & Monte, D. A. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012122 · Cited by 158 · see citing works
Rosenbloom, B. E., Balwani, M., Bronstein, J. M., et al. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.10.006 · Cited by 158 · see citing works
Leçons sur les maladies du système nerveux
Charcot, J.-M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9781139105361 · Cited by 149 · see citing works
Disentangling the Relationship between Lewy Bodies and Nigral Neuronal Loss in Parkinson's Disease
Parkkinen, L., O’Sullivan, S. S., Collins, C., Petrie, A., Holton, J. L., Révész, T., & Lees, A. J. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-11046 · Cited by 148 · see citing works
Presenile dementia with Alzheimer-, Pick- and Lewy-body changes
Kosaka, K., Oyanagi, S., Matsushita, M., et al. (1976) · Acta Neuropathologica · doi:10.1007/bf00685366 · Cited by 146 · see citing works
L-DOPA IN POSTENCEPHALITIC PARKINSONISM
Calne, D. B., Stern, G. M., Laurence, D. R., et al. (1969) · The Lancet · doi:10.1016/s0140-6736(69)91751-6 · Cited by 146 · see citing works
Exploring the link between glucocerebrosidase mutations and parkinsonism
Westbroek, W., Gustafson, A. M., & Sidransky, E. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.05.003 · Cited by 144 · see citing works
A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
Pouclet, H., Lebouvier, T., Coron, E., Bruley des Varannes, S., Rouaud, T., Roy, M., Neunlist, M., & Derkinderen, P. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.014 · Cited by 138 · see citing works
Emmer, K. L., Waxman, E. A., Covy, J. P., & Giasson, B. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.247965 · Cited by 133 · see citing works
Fumimura, Y., Ikemura, M., Saito, Y., Sengoku, R., Kanemaru, K., Sawabe, M., Arai, T., Ito, G., Iwatsubo, T., Fukayama, M., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180517454 · Cited by 131 · see citing works
Greffard, S., Verny, M., Bonnet, A.-M., Seilhean, D., Hauw, J., & Duyckaerts, C. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.015 · Cited by 130 · see citing works
Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
Beach, T. G., Adler, C. H., Sue, L. I., Peirce, J. B., Bachalakuri, J., Dalsing-Hernandez, J. E., Lue, L. F., Caviness, J. N., Connor, D. J., Sabbagh, M. N., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-007-0313-7 · Cited by 128 · see citing works
α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals
Klos, K. J., Ahlskog, J. E., Josephs, K. A., Apaydın, H., Parisi, J. E., Boeve, B. F., DeLucia, M. W., & Dickson, D. W. (2006) · Neurology · doi:10.1212/01.wnl.0000204179.88955.fa · Cited by 127 · see citing works
Evidence in favor of Braak staging of Parkinson's disease
Dickson, D. W., Uchikado, H., Fujishiro, H., & Tsuboi, Y. (2010) · Movement Disorders · doi:10.1002/mds.22637 · Cited by 126 · see citing works
-Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies
Lim, Y., Kehm, V. M., Lee, E. B., Soper, J. H., Li, C., Trojanowski, J. Q., & Lee, V. M. Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0618-11.2011 · Cited by 113 · see citing works
Taschenberger, G., Garrido, M., Tereshchenko, Y., Bähr, M., Zweckstetter, M., & Kügler, S. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0926-8 · Cited by 100 · see citing works
Bumk, E., & Foerste, R. (1939) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193908000-00006 · Cited by 99 · see citing works
Friedrich Heinrich Lewy (1885?1950) and His Work
Holdorff, B. (2002) · Journal of the History of the Neurosciences · doi:10.1076/jhin.11.1.19.9106 · Cited by 86 · see citing works
Die Lehre vom Tonus und der Bewegung.
(1923) · JAMA · doi:10.1001/jama.1923.02650110079046 · Cited by 83 · see citing works
Causal relation between α synuclein gene duplication and familial Parkinson’s disease
Inserm, U. (2005) · Dkgest of the World Latest Medical Information · Cited by 81 · see citing works
Jelliffe (1911) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-191105000-00015 · Cited by 80 · see citing works
Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?
Halliday, G. M., McCann, H., & Shepherd, C. E. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.47 · Cited by 74 · see citing works
Ghebremedhin, E., Tredici, K. D., Langston, J. W., & Braak, H. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0596-y · Cited by 74 · see citing works
Self-citationAssociation of the human leucocyte antigen region with susceptibility to Parkinson's disease
Saiki, M., Baker, A., Williams‐Gray, C. H., Foltynie, T., Goodman, R. S., Taylor, C. J., Compston, D. A. S., Barker, R., Sawcer, S. J., & Goris, A. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.162883 · Cited by 68 · see citing works
Who was the man who discovered the “Lewy bodies”?
Silva, A. M. R. E., Geldsetzer, F. O., Holdorff, B., KIELHORN, F., Balzer‐Geldsetzer, M., Oertel, W. H., Hurtig, H. H., & Dodel, R. C. (2010) · Movement Disorders · doi:10.1002/mds.22956 · Cited by 58 · see citing works
Pale Neurites, Premature α‐Synuclein Aggregates with Centripetal Extension from Axon Collaterals
Kanazawa, T., Adachi, E., Orimo, S., Nakamura, A., Mizusawa, H., & Uchihara, T. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00509.x · Cited by 56 · see citing works
Sur un cas de tremblement parkinsonien hémiplégique symptomatique d'une tumeur du pédoncule cérébral
Blocq, P., & Marinesco, G. (1893) · Medical Entomology and Zoology · Cited by 55 · see citing works
Dugger, B. N., & Dickson, D. W. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0739-1 · Cited by 47 · see citing works
Emerging evidence for the neuroprotective role of α-synuclein
Lee, H., Zhu, X., Takeda, A., Perry, G. L., & Smith, M. A. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.04.024 · Cited by 33 · see citing works
Olfactory Function in Parkinson's Disease
Haehner, A., Hummel, T. R., & Reichmann, H. (2010) · European Neurological Review · doi:10.17925/enr.2010.05.01.26 · Cited by 29 · see citing works
Alpha-synuclein studies are negative in postencephalic parkinsonism of von Economo
Josephs, K. A., Parisi, J. E., & Dickson, D. W. (2002) · Neurology · doi:10.1212/wnl.59.4.645 · Cited by 26 · see citing works
Ahn, T. B., Langston, J. W., Aachi, V. R., & Dickson, D. W. (2012) · Europe PMC (PubMed Central) · Cited by 24 · see citing works
The Diseases of the Basal Ganglia.
German, W. J. (1943) · PubMed Central · Cited by 20 · see citing works
What's in a name? Dr. Lewey and the Lewy body
Sweeney, P. J., Lloyd, M. F., & Daroff, R. B. (1997) · Neurology · doi:10.1212/wnl.49.2.629 · Cited by 10 · see citing works
Lewy, F. H. (1932) · Journal of Neurology · doi:10.1007/bf01652906 · Cited by 9 · see citing works
Kosaka, K., & Manabe, Y. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2010.01128.x · Cited by 5 · see citing works
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The connectomics of brain disorders
Fornito, A., Zalesky, A., & Breakspear, M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3901 · Cited by 1,734 · see citing works
Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789 · see citing works
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2013) · Nature · doi:10.1038/nature12481 · Cited by 1,663 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Biomarkers for neurodegenerative diseases
Hansson, O. (2021) · Nature Medicine · doi:10.1038/s41591-021-01382-x · Cited by 1,159 · see citing works
Tau pathology and neurodegeneration
Spillantini, M. G., & Goedert, M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70090-5 · Cited by 1,133 · see citing works
Self-citationMaternal immune activation and abnormal brain development across CNS disorders
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880 · see citing works
Bendor, J. T., Logan, T. P., & Edwards, R. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.004 · Cited by 825 · see citing works
Oxidative stress and Parkinson’s disease
Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00091 · Cited by 878 · see citing works
Ambadipudi, S., Biernat, J., Riedel, D., Mandelkow, E., & Zweckstetter, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00480-0 · Cited by 782 · see citing works
Spreading of pathology in neurodegenerative diseases: a focus on human studies
Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works
Self-citationMicrobiome–microglia connections via the gut–brain axis
Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471 · see citing works
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0238-6 · Cited by 450 · see citing works
Neurodegenerative Diseases: Expanding the Prion Concept
Walker, L. C., & Jucker, M. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033828 · Cited by 361 · see citing works
Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
Goedert, M., Masuda-Suzukake, M., & Falcon, B. (2017) · Brain · doi:10.1093/brain/aww230 · Cited by 323 · see citing works
Self-citationVagal neurocircuitry and its influence on gastric motility
Travagli, R. A., & Anselmi, L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.76 · Cited by 323 · see citing works
Regulation of α-synuclein by chaperones in mammalian cells
Burmann, B. M., Gerez, J. A., Matečko-Burmann, I., Campioni, S., Kumari, P., Ghosh, D., Mazur, A., Aspholm, E. E., Šulskis, D., Wawrzyniuk, M., et al. (2020) · Nature · doi:10.1038/s41586-019-1808-9 · Cited by 255 · see citing works
Uchihara, T., & Giasson, B. I. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1485-1 · Cited by 249 · see citing works
Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus
Ashraf, G., Greig, N., Khan, T., Hassan, I., Tabrez, S., Shakil, S., Sheikh, I., Zaidi, S., Akram, M., Jabir, N., et al. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140917095514 · Cited by 236 · see citing works
α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease
Chandra, R., Hiniker, A., Kuo, Y.-M., Nussbaum, R. L., & Liddle, R. A. (2017) · JCI Insight · doi:10.1172/jci.insight.92295 · Cited by 236 · see citing works
Sex differences in movement disorders
Meoni, S., Macerollo, A., & Moro, E. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0294-x · Cited by 207 · see citing works
Mutant huntingtin is present in neuronal grafts in huntington disease patients
Cicchetti, F., Lacroix, S., Cisbani, G., Vallières, N., Saint‐Pierre, M., St‐Amour, I., Tolouei, R., Skepper, J. N., Hauser, R. A., Mantovani, D., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24174 · Cited by 193 · see citing works
Gorecki, A. M., Preskey, L., Bakeberg, M. C., Kenna, J. E., Gildenhuys, C., MacDougall, G., Dunlop, S. A., Mastaglia, F. L., Akkari, P. A., Koengten, F., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00839 · Cited by 184 · see citing works
Inflammation in Parkinson’s disease: role of glucocorticoids
Herrero, M.-T., Estrada, C., Maatouk, L., & Vyas, S. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00032 · Cited by 175 · see citing works
Involvement of the kynurenine pathway in the pathogenesis of Parkinson's disease
Lim, C. K., Fernández-Gomez, F. J., Braidy, N., Estrada, C., Costa, C., Costa, S., Bessede, A., Fernandez-Villalba, E., Zinger, A., Herrero, M. T., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.009 · Cited by 159 · see citing works
Invited review: Prion‐like transmission and spreading of tau pathology
Clavaguera, F., Hench, J., Goedert, M., & Tolnay, M. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12197 · Cited by 156 · see citing works
Self-citationRoeters, S. J., Iyer, A., Pletikapić, G., Kogan, V., Subramaniam, V., & Woutersen, S. (2017) · Scientific Reports · doi:10.1038/srep41051 · Cited by 146 · see citing works
Schildknecht, S., Gerding, H. R., Karreman, C., Drescher, M., Lashuel, H. A., Outeiro, T. F., Di Monte, D. A., & Leist, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12226 · Cited by 148 · see citing works
RETRACTED ARTICLE: LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
Bae, E.-J., Kim, D.-K., Kim, C., Mante, M., Adame, A., Rockenstein, E., Ulusoy, A., Klinkenberg, M., Jeong, G. R., Bae, J. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05958-z · Cited by 149 · see citing works
RetractedMesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
Staff, N. P., Jones, D. T., & Singer, W. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.001 · Cited by 150 · see citing works
A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology
Wie, J., Liu, Z., Song, H., Tropea, T. F., Yang, L., Wang, H., Liang, Y., Cang, C., Aranda, K., Lohmann, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03185-z · Cited by 120 · see citing works
Gaikwad, S., Senapati, S., Haque, M. A., & Kayed, R. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13490 · Cited by 117 · see citing works
Gustavsson, E. K., Follett, J., Trinh, J., Barodia, S. K., Real, R., Liu, Z., Grant-Peters, M., Fox, J. D., Appel-Cresswell, S., Stoessl, A. J., et al. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00121-2 · Cited by 114 · see citing works
Neuroplasticity and the next wave of antidepressant strategies
Hayley, S., & Litteljohn, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00218 · Cited by 92 · see citing works
The gut-brain axis rewired: adding a functional vagal nicotinic “sensory synapse”
Perez‐Burgos, A., Mao, Y., Bienenstock, J., & Kunze, W. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-245282 · Cited by 91 · see citing works
Tsao, S.-P., Nurrahma, B. A., Kumar, R., Wu, C.-H., Yeh, T.-H., Chiu, C.-C., Lee, Y.-P., Liao, Y.-C., Huang, C.-H., Yeh, Y.-T., et al. (2021) · Antioxidants · doi:10.3390/antiox10111823 · Cited by 79 · see citing works
Inhibition of synucleinopathic seeding by rationally designed inhibitors
Sangwan, S., Sahay, S., Murray, K. A., Morgan, S., Guenther, E. L., Jiang, L., Williams, C. K., Vinters, H. V., Goedert, M., & Eisenberg, D. S. (2020) · eLife · doi:10.7554/elife.46775 · Cited by 79 · see citing works
Self-citationMachado, V., Zöller, T., Attaai, A., & Spittau, B. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020151 · Cited by 76 · see citing works
Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat
Anselmi, L., Bove, C., Coleman, F. H., Le, K., Subramanian, M. P., Venkiteswaran, K., Subramanian, T., & Travagli, R. A. (2018) · npj Parkinson's Disease · doi:10.1038/s41531-018-0066-0 · Cited by 63 · see citing works
Acuña, L., Hamadat, S., Corbalán, N. S., González-Lizárraga, F., dos-Santos-Pereira, M., Rocca, J., Sepúlveda Díaz, J., Del-Bel, E., Papy-García, D., Chehín, R. N., et al. (2019) · Cells · doi:10.3390/cells8080776 · Cited by 62 · see citing works
Choudhury, S. P., Bano, S., Sen, S., Suchal, K., Kumar, S., Nikolajeff, F., Dey, S. K., & Sharma, V. (2022) · npj Parkinson's Disease · doi:10.1038/s41531-022-00324-9 · Cited by 52 · see citing works
Zhu, Y., Huan, F., Wang, J., Xie, X., Yu, G., Wang, X., Jiang, L., Gao, R., Xiao, H., Ding, H., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00475 · Cited by 48 · see citing works
Surova, Y., Lampinen, B., Nilsson, M., Lätt, J., Hall, S., Widner, H., study, S. B., van Westen, D., & Hansson, O. (2016) · PLOS ONE · doi:10.1371/journal.pone.0157755 · Cited by 51 · see citing works
Zapała, B., Stefura, T., Wójcik-Pędziwiatr, M., Kabut, R., Bałajewicz-Nowak, M., Milewicz, T., Dudek, A., Stój, A., & Rudzińska-Bar, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235698 · Cited by 44 · see citing works
Mendes, M. O., Rosa, A. I., Carvalho, A. N., Nunes, M. J., Dionísio, P., Rodrigues, E., Costa, D., Duarte-Silva, S., Maciel, P., Rodrigues, C. M. P., et al. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.01.003 · Cited by 31 · see citing works
ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease
Siokas, V., Aloizou, A.-M., Tsouris, Z., Liampas, I., Liakos, P., Calina, D., Docea, A. O., Tsatsakis, A., Bogdanos, D. P., Hadjigeorgiou, G. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030381 · Cited by 29 · see citing works
Drobny, A., Ngo, P. A., Neurath, M. F., Zunke, F., & López-Posadas, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655123 · Cited by 24 · see citing works
Cellular maintenance of nuclear protein homeostasis.
Gallagher, P. S., Oeser, M. L., Abraham, A.-C., Kaganovich, D., & Gardner, R. G. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1530-y · Cited by 22 · see citing works
Computational model of visual hallucination in dementia with Lewy bodies
Tsukada, H., Fujii, H., Aihara, K., & Tsuda, I. (2015) · Neural Networks · doi:10.1016/j.neunet.2014.09.001 · Cited by 17 · see citing works
Ji, T., Huang, H., Liu, J., Peng, T., Zhou, X., Tan, Q., Yuan, J., Hua, H., Ding, S., & Liu, H. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14952 · Cited by 17 · see citing works
Moussa, C. E.-H. (2015) · Neurodegenerative Diseases · doi:10.1159/000430888 · Cited by 13 · see citing works
Thomsen, M., Stoica, A., Christensen, K. V., Fryland, T., Mikkelsen, J. D., & Hansen, J. B. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114209 · Cited by 8 · see citing works
- Authors
- Goedert, M., Spillantini, M. G., Del Tredici, K., & Braak, H.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- University of Cambridge (GB)
- Universität Ulm (DE)
- Corresponding author
- Goedert, Michel
- Venue
- Nature Reviews Neurology
- Published
- 2012-11-27
- Volume
- 9
- Issue
- 1
- Pages
- 13-24
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2089522371
- Cited by
- 1,190
- References
- 166
- Citations by year
- 2026: 65 · 2025: 77 · 2024: 94 · 2023: 96 · 2022: 105 · 2021: 113 · 2020: 124 · 2019: 100 · 2018: 78 · 2017: 90 · 2016: 86 · 2015: 60 · 2014: 56 · 2013: 45
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Parkinson's UK (G-1102, K-1012)
- Research Councils UK
- Deutsche Forschungsgemeinschaft
- Medical Research Council
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Lewy body pathology, Parkinson's disease, alpha-synuclein aggregation, Lewy bodies, dementia with Lewy bodies, multiple system atrophy, substantia nigra, neurodegeneration
- MeSH terms
- Brain, Germany, Humans, Parkinson Disease, Multiple System Atrophy, Lewy Body Disease, History, 19th Century, History, 20th Century, History, 21st Century, alpha-Synuclein
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