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Alcohol-Induced Hepatic Injury in Nonalcoholic Volunteers
Abstract
Isocaloric substitution of alcohol for carbohydrate in young nonalcoholic volunteers rapidly led to hepatic fat accumulation and ultrastructural changes, both on a standard diet and on a diet high in protein and low in fat. The addition of alcohol to a normal diet for two days resulted in similar changes, which could not be prevented by a diet high in protein with minimal fat (5 per cent of total calories). Blood alcohol levels in every subject studied were almost all well below accepted legal limits for intoxication. The data indicate that in normal nonalcoholic people, alcohol itself is hepatotoxic, independent of nutritional factors. Nonalcoholic people are not less susceptible than alcoholic patients to the injurious effects of alcohol. Amounts of alcohol consumed by many "social" drinkers are enough to damage the liver, and one need never have been drunk to sustain alcohol-induced hepatic injury.
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Citations
Cited by
ACG Clinical Guideline: Alcoholic Liver Disease
Singal, A. K., Bataller, R., Ahn, J., Kamath, P. S., & Shah, V. H. (2018) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.469 · Cited by 835
Crabb, D. W., Bataller, R., Chalasani, N. P., Kamath, P. S., Lucey, M., Mathurin, P., McClain, C., McCullough, A., Mitchell, M. C., Morgan, T. R., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.042 · Cited by 553
Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men
Gordon, G. G., Altman, K., Southren, A. L., Rubin, E., & Lieber, C. S. (1976) · New England Journal of Medicine · doi:10.1056/nejm197610072951501 · Cited by 364
Self-citationCIRRHOSIS IN THE ALCOHOLIC AND ITS RELATION TO THE VOLUME OF ALCOHOL ABUSE
Lelbach, W. K. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb19146.x · Cited by 339
Younossi, Z., & Henry, L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.005 · Cited by 334
“cirrhosis [10, 11, 47-49] Nevertheless, liver disea se progresses more rapidly in patients with”
Background
Metadata
- Authors
- Rubin, E., & Lieber, C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1968-04-18
- Volume
- 278
- Issue
- 16
- Pages
- 869-876
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2332581431
- Cited by
- 360
- References
- 0
- FWCI
- 53.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rubin, E., & Lieber, C. S. (1968). Alcohol-Induced Hepatic Injury in Nonalcoholic Volunteers. New England Journal of Medicine. https://doi.org/10.1056/nejm196804182781602
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
